Polygenic Score (PGS) ID: PGS003412

Predicted Trait
Reported Trait Melanoma
Mapped Trait(s) melanoma (EFO_0000756)
Released in PGS Catalog: Feb. 8, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS28_melanoma
Development Method
Name Genome-wide significant variants
Parameters P < 5E-7
Variants
Original Genome Build hg19
Number of Variants 28
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000424
Citation (link to publication) Olsen CM et al. Br J Dermatol (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
36,077 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST003061
Europe PMC: 26237428
36,077 individualsEuropeanNR
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM017060PSS010106|
European Ancestry|
15,373 individuals
PGP000424 |
Olsen CM et al. Br J Dermatol (2019)
Reported Trait: Melanoma——Hazard ratio (HR, high vs low tertile): 3.02 [2.01, 4.53]——
PPM017061PSS010107|
European Ancestry|
38,845 individuals
PGP000425 |
Olsen CM et al. JAMA Dermatol (2023)
|Ext.		Reported Trait: Second primary melanoma——Hazard ratio (HR, high vs low tertile): 3.28 [2.06, 5.23]——
PPM017062PSS010107|
European Ancestry|
38,845 individuals
PGP000425 |
Olsen CM et al. JAMA Dermatol (2023)
|Ext.		Reported Trait: First primary melanoma——Hazard ratio (HR, high vs low tertile): 2.06 [1.71, 2.49]——
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS010106—Median = 4.4 years15,373 individuals,
45.0 % Male samples
Mean = 57.0 yearsEuropean—QSKIN—
PSS010107—Median = 7.4 years38,845 individuals,
46.0 % Male samples
Mean = 56.1 yearsEuropean—QSKIN—
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