Predicted Trait | |
Reported Trait | Melanoma |
Mapped Trait(s) | melanoma (EFO_0000756) |
Score Construction | |
PGS Name | PRS28_melanoma |
Development Method | |
Name | Genome-wide significant variants |
Parameters | P < 5E-7 |
Variants | |
Original Genome Build | hg19 |
Number of Variants | 28 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000424 |
Citation (link to publication) | Olsen CM et al. Br J Dermatol (2019) |
Ancestry Distribution | |
Source of Variant Associations (GWAS) | European: 100% 36,077 individuals (100%) |
PGS Evaluation | European: 100% 2 Sample Sets |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
---|---|---|---|
GWAS Catalog: GCST003061 Europe PMC: 26237428 | 36,077 individuals | European | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM017060 | PSS010106| European Ancestry| 15,373 individuals | PGP000424 | Olsen CM et al. Br J Dermatol (2019) | Reported Trait: Melanoma | — | — | Hazard ratio (HR, high vs low tertile): 3.02 [2.01, 4.53] | — | — |
PPM017061 | PSS010107| European Ancestry| 38,845 individuals | PGP000425 | Olsen CM et al. JAMA Dermatol (2023) |Ext. | Reported Trait: Second primary melanoma | — | — | Hazard ratio (HR, high vs low tertile): 3.28 [2.06, 5.23] | — | — |
PPM017062 | PSS010107| European Ancestry| 38,845 individuals | PGP000425 | Olsen CM et al. JAMA Dermatol (2023) |Ext. | Reported Trait: First primary melanoma | — | — | Hazard ratio (HR, high vs low tertile): 2.06 [1.71, 2.49] | — | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
|
---|---|---|---|---|---|---|---|---|
PSS010106 | — | Median = 4.4 years | 15,373 individuals, 45.0 % Male samples | Mean = 57.0 years | European | — | QSKIN | — |
PSS010107 | — | Median = 7.4 years | 38,845 individuals, 46.0 % Male samples | Mean = 56.1 years | European | — | QSKIN | — |