PGS Publication: PGP000424

Publication Information (EuropePMC)
Title Does polygenic risk influence associations between sun exposure and melanoma? A prospective cohort analysis.
PubMed ID 31747047(Europe PMC)
doi 10.1111/bjd.18703
Publication Date Dec. 17, 2019
Journal Br J Dermatol
Author(s) Olsen CM, Pandeya N, Law MH, MacGregor S, Iles MM, Thompson BS, Green AC, Neale RE, Whiteman DC, QSkin Study.
Released in PGS Catalog: Feb. 8, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003412
(PRS28_melanoma)
 PGP000424 |
Olsen CM et al. Br J Dermatol (2019)
 Melanoma melanoma 28
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003412/ScoringFiles/PGS003412.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017060 PGS003412
(PRS28_melanoma)
 PSS010106|
European Ancestry|
15,373 individuals
 PGP000424 |
Olsen CM et al. Br J Dermatol (2019)
 Reported Trait: Melanoma — — Hazard ratio (HR, high vs low tertile): 3.02 [2.01, 4.53] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010106 — Median = 4.4 years 15,373 individuals,
45.0 % Male samples
 Mean = 57.0 years European — QSKIN —