Polygenic Score (PGS) ID: PGS003446

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: March 24, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name TEM_CAD_PRS
Development Method
Name PRSice
Parameters R2=0.8, p=0.01, kb=250
Variants
Original Genome Build GRCh37
Number of Variants 538,084
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000446
Citation (link to publication) Tcheandjieu C et al. Nat Med (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 80.6%
African: 13.5%
Hispanic or Latin American: 5.9%
959,564 individuals (100%)
PGS Evaluation
European: 50%
African: 25%
Hispanic or Latin American: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90132305
Europe PMC: 35915156
 773,268 individuals European BBJ, CARDIoGRAMplusC4D, MVP, UKB
GWAS Catalog: GCST90132305
Europe PMC: 35915156
 56,970 individuals Hispanic or Latin American BBJ, CARDIoGRAMplusC4D, MVP, UKB
GWAS Catalog: GCST90132305
Europe PMC: 35915156
 129,326 individuals African American or Afro-Caribbean BBJ, CARDIoGRAMplusC4D, MVP, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017186 PSS010158|
African Ancestry|
17,072 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
 Reported Trait: Coronary artery disease OR: 1.21 [1.15, 1.28] — — — —
PPM017187 PSS010159|
Hispanic or Latin American Ancestry|
6,314 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
 Reported Trait: Coronary artery disease OR: 1.43 [1.27, 1.61] — — — —
PPM017185 PSS010163|
European Ancestry|
67,738 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
 Reported Trait: Coronary artery disease OR: 1.35 [1.31, 138.0] — — — —
PPM021717 PSS011762|
European Ancestry|
8,417 individuals
 PGP000665 |
Moreno-Grau S et al. Human Genomics (2024)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.6 [1.42, 1.82] AUROC: 0.82 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010158 — —
[
  • 1,552 cases
  • , 15,520 controls
]
 — African American or Afro-Caribbean — MVP —
PSS010159 — —
[
  • 574 cases
  • , 5,740 controls
]
 — Hispanic or Latin American — MVP —
PSS011762 — — 8,417 individuals — European — BBofA —
PSS010163 — —
[
  • 6,158 cases
  • , 61,580 controls
]
 — European — MVP —