PGS Publication: PGP000446

Publication Information (EuropePMC)
Title Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.
PubMed ID 35915156(Europe PMC)
doi 10.1038/s41591-022-01891-3
Publication Date Aug. 1, 2022
Journal Nat Med
Author(s) Tcheandjieu C, Zhu X, Hilliard AT, Clarke SL, Napolioni V, Ma S, Lee KM, Fang H, Chen F, Lu Y, Tsao NL, Raghavan S, Koyama S, Gorman BR, Vujkovic M, Klarin D, Levin MG, Sinnott-Armstrong N, Wojcik GL, Plomondon ME, Maddox TM, Waldo SW, Bick AG, Pyarajan S, Huang J, Song R, Ho YL, Buyske S, Kooperberg C, Haessler J, Loos RJF, Do R, Verbanck M, Chaudhary K, North KE, Avery CL, Graff M, Haiman CA, Le Marchand L, Wilkens LR, Bis JC, Leonard H, Shen B, Lange LA, Giri A, Dikilitas O, Kullo IJ, Stanaway IB, Jarvik GP, Gordon AS, Hebbring S, Namjou B, Kaufman KM, Ito K, Ishigaki K, Kamatani Y, Verma SS, Ritchie MD, Kember RL, Baras A, Lotta LA, Regeneron Genetics Center, CARDIoGRAMplusC4D Consortium, Biobank Japan, Million Veteran Program, Kathiresan S, Hauser ER, Miller DR, Lee JS, Saleheen D, Reaven PD, Cho K, Gaziano JM, Natarajan P, Huffman JE, Voight BF, Rader DJ, Chang KM, Lynch JA, Damrauer SM, Wilson PWF, Tang H, Sun YV, Tsao PS, O'Donnell CJ, Assimes TL.
Released in PGS Catalog: March 24, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003446
(TEM_CAD_PRS)
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
 Coronary artery disease coronary artery disease 538,084
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003446/ScoringFiles/PGS003446.txt.gz

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000018
(metaGRS_CAD)
 PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
 Coronary artery disease coronary artery disease 1,745,179
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz
PGS000013
(GPS_CAD)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Coronary artery disease coronary artery disease 6,630,150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017186 PGS003446
(TEM_CAD_PRS)
 PSS010158|
African Ancestry|
17,072 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
 Reported Trait: Coronary artery disease OR: 1.21 [1.15, 1.28] — — — —
PPM017187 PGS003446
(TEM_CAD_PRS)
 PSS010159|
Hispanic or Latin American Ancestry|
6,314 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
 Reported Trait: Coronary artery disease OR: 1.43 [1.27, 1.61] — — — —
PPM017189 PGS000013
(GPS_CAD)
 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization OR: 1.52 [1.45, 1.59] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017190 PGS000013
(GPS_CAD)
 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization OR: 1.17 [1.14, 1.21] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017191 PGS000013
(GPS_CAD)
 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.36 [1.35, 1.37] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017192 PGS000013
(GPS_CAD)
 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.32 [1.28, 1.36] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017193 PGS000013
(GPS_CAD)
 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.1 [1.08, 1.12] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017194 PGS000013
(GPS_CAD)
 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.46 [1.43, 1.49] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017196 PGS000013
(GPS_CAD)
 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.15 [1.1, 1.2] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017197 PGS000013
(GPS_CAD)
 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Incident coronary artery disease OR: 1.26 [1.24, 1.28] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017198 PGS000013
(GPS_CAD)
 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Incident coronary artery disease OR: 1.22 [1.15, 1.29] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017199 PGS000013
(GPS_CAD)
 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Incident coronary artery disease OR: 1.1 [1.07, 1.14] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017200 PGS000018
(metaGRS_CAD)
 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization OR: 1.54 [1.52, 1.56] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017201 PGS000018
(metaGRS_CAD)
 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization OR: 1.62 [1.54, 1.71] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017202 PGS000018
(metaGRS_CAD)
 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization OR: 1.2 [1.17, 1.2] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017203 PGS000018
(metaGRS_CAD)
 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.38 [1.36, 1.39] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017204 PGS000018
(metaGRS_CAD)
 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.39 [1.34, 1.43] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017205 PGS000018
(metaGRS_CAD)
 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Coronary artery disease OR: 1.12 [1.1, 1.14] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017206 PGS000018
(metaGRS_CAD)
 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.47 [1.44, 1.5] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017207 PGS000018
(metaGRS_CAD)
 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.5 [1.38, 1.63] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017208 PGS000018
(metaGRS_CAD)
 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.17 [1.12, 1.22] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017209 PGS000018
(metaGRS_CAD)
 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Incident coronary artery disease OR: 1.27 [1.25, 1.29] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017210 PGS000018
(metaGRS_CAD)
 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Incident coronary artery disease OR: 1.24 [1.17, 1.32] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017211 PGS000018
(metaGRS_CAD)
 PSS010160|
African Ancestry|
76,709 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Incident coronary artery disease OR: 1.1 [1.07, 1.14] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017185 PGS003446
(TEM_CAD_PRS)
 PSS010163|
European Ancestry|
67,738 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
 Reported Trait: Coronary artery disease OR: 1.35 [1.31, 138.0] — — — —
PPM017188 PGS000013
(GPS_CAD)
 PSS010162|
European Ancestry|
292,438 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization OR: 1.51 [1.49, 1.53] — — age, sex, genotyping batch and top 10 genotype-based PCs —
PPM017195 PGS000013
(GPS_CAD)
 PSS010161|
Hispanic or Latin American Ancestry|
30,648 individuals
 PGP000446 |
Tcheandjieu C et al. Nat Med (2022)
|Ext.		 Reported Trait: Acute myocardial infarction or revascularization in incident coronary artery disease OR: 1.49 [1.38, 1.61] — — age, sex, genotyping batch and top 10 genotype-based PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010158 — —
[
  • 1,552 cases
  • , 15,520 controls
]
 — African American or Afro-Caribbean — MVP —
PSS010159 — —
[
  • 574 cases
  • , 5,740 controls
]
 — Hispanic or Latin American — MVP —
PSS010160 — —
[
  • 17,202 cases
  • , 59,507 controls
]
 — African American or Afro-Caribbean — MVP —
PSS010161 — —
[
  • 6,378 cases
  • , 24,270 controls
]
 — Hispanic or Latin American — MVP —
PSS010162 — —
[
  • 95,151 cases
  • , 197,287 controls
]
 — European — MVP —
PSS010163 — —
[
  • 6,158 cases
  • , 61,580 controls
]
 — European — MVP —