Predicted Trait | |
Reported Trait | Systolic blood pressure |
Mapped Trait(s) | systolic blood pressure (EFO_0006335) |
Score Construction | |
PGS Name | SBP |
Development Method | |
Name | PRS-CS |
Parameters | phi=(1, 1x10^-2, 1x10^-4, and 1x10^-6 ) |
Variants | |
Original Genome Build | hg37 |
Number of Variants | 1,064,898 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000462 |
Citation (link to publication) | Honigberg MC et al. Nat Med (2023) |
Study Identifiers
|
Sample Numbers
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Sample Ancestry
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Cohort(s)
|
---|---|---|---|
Europe PMC: 30578418 | 220,496 individuals | European | MVP |
Study Identifiers
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Sample Numbers
|
Sample Ancestry
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Cohort(s)
|
Phenotype Definitions & Methods
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Age of Study Participants
|
Participant Follow-up Time
|
Additional Ancestry Description
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Additional Sample/Cohort Information
|
---|---|---|---|---|---|---|---|---|
— | 212,034 individuals | European | UKB | 423 women with a history of 255 preeclampsia/eclampsia, 482 women with a history of gestational hype... rtension only, and 256 211,129 parous women without a reported history of HDPsShow more | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
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Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM018282 | PSS010956| European Ancestry| 25,582 individuals | PGP000462 | Honigberg MC et al. Nat Med (2023) | Reported Trait: Pre-eclampsia/eclampsia | OR: 1.24 [1.17, 1.3] | — | — | maternal age at delivery, age2, and the first ten principal components of genetic ancestry | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
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Additional Ancestry Description
|
Cohort(s)
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Additional Sample/Cohort Information
|
---|---|---|---|---|---|---|---|---|
PSS010956 | — | — | [
| — | European | — | HUNT | — |