Polygenic Score (PGS) ID: PGS003764

Predicted Trait
Reported Trait Sleep duration
Mapped Trait(s) sleep duration (EFO_0005271)
Released in PGS Catalog: Aug. 4, 2023
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Score Details

Score Construction
PGS Name PRS78_sleep duration
Development Method
Name Genome-wide significant SNPs
Parameters p<5E-08
Variants
Original Genome Build GRCh37
Number of Variants 78
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000487
Citation (link to publication) Scammell BH et al. Hum Mol Genet (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
446,118 individuals (100%)
PGS Evaluation
African: 33.3%
East Asian: 33.3%
South Asian: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007561
Europe PMC: 30846698
 446,118 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018565 PSS011028|
East Asian Ancestry|
13,618 individuals
 PGP000487 |
Scammell BH et al. Hum Mol Genet (2023)
 Reported Trait: sleep duration β: 0.38 [0.22, 0.54] — — — beta calculated as min/allele
PPM018566 PSS011027|
African Ancestry|
7,288 individuals
 PGP000487 |
Scammell BH et al. Hum Mol Genet (2023)
 Reported Trait: sleep duration β: 0.62 [0.41, 0.83] — — — beta calculated as min/allele
PPM018567 PSS011029|
South Asian Ancestry|
7,485 individuals
 PGP000487 |
Scammell BH et al. Hum Mol Genet (2023)
 Reported Trait: sleep duration β: 0.39 [0.04, 0.74] — — — beta calculated as min/allele

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011029 — — 7,485 individuals,
53.9 % Male samples
 Mean = 53.39 years
Sd = 8.46 years		 South Asian — UKB —
PSS011027 — — 7,288 individuals,
42.1 % Male samples
 Mean = 51.82 years
Sd = 8.06 years		 African unspecified — UKB —
PSS011028 — — 13,618 individuals,
45.3 % Male samples
 Mean = 54.6 years
Sd = 9.4 years		 East Asian — J-MICC —