| Predicted Trait | |
| Reported Trait | LDL cholesterol |
| Mapped Trait(s) | low density lipoprotein cholesterol measurement (EFO_0004611) |
| Score Construction | |
| PGS Name | LDL_EUR_LDpred2 |
| Development Method | |
| Name | LDpred2 |
| Parameters | causal SNPs protions vary with length 17 that are evened spaced on a logorithmic sale from 1E-04 to ... 1Show more |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 1,490,736 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000489 |
| Citation (link to publication) | Zhang H et al. Nat Genet (2023) |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
|---|---|---|---|
Europe PMC: 34887591 | 842,660 individuals | European | NR |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
Phenotype Definitions & Methods
|
Age of Study Participants
|
Participant Follow-up Time
|
Additional Ancestry Description
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| — | 9,527 individuals, 47.0 % Male samples | European | NR | — | Mean = 56.86 years Sd = 8.05 years | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM018592 | PSS011045| European Ancestry| 9,527 individuals | PGP000489 | Zhang H et al. Nat Genet (2023) | Reported Trait: Low-density lipoprotein cholesterol | — | — | R²: 0.05473 | — | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS011045 | — | — | 9,527 individuals, 47.0 % Male samples | Mean = 56.86 years Sd = 8.05 years | European | — | UKB | — |