| Predicted Trait | |
| Reported Trait | Addiction risk factors |
| Mapped Trait(s) | substance-related disorder (MONDO_0002494) |
| Additional Trait Information | meta-analysis of Cannabis Use Disorder, problematic Tobacco use, problematic alcohol use, and opioid use disorder |
| Score Construction | |
| PGS Name | PRSaddiction-rf |
| Development Method | |
| Name | PRS-CS |
| Parameters | Whole genome score using PRS-cs Auto. Used 1000K genome panel. Scores are poseterior probability we... ights per snp.Show more |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 584,753 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000490 |
| Citation (link to publication) | Hatoum AS et al. Nat Ment Health (2023) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 1,025,550 individuals (100%) |
| PGS Evaluation | European: 100% 1 Sample Sets |
Study Identifiers
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Sample Numbers
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Sample Ancestry
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Cohort(s)
|
|---|---|---|---|
| — | 1,025,550 individuals | European | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM018656 | PSS011056| European Ancestry| 1,986 individuals | PGP000490 | Hatoum AS et al. Nat Ment Health (2023) | Reported Trait: Alcohol Use Disorder | OR: 1.57 β: 0.451 (0.052) | — | — | First 10 principal components, age, and sex | — |
| PPM018657 | PSS011056| European Ancestry| 1,986 individuals | PGP000490 | Hatoum AS et al. Nat Ment Health (2023) | Reported Trait: Tobacco Use Disorder | OR: 1.643 β: 0.497 (0.054) | — | — | First 10 principal components, age, and sex | — |
| PPM018658 | PSS011056| European Ancestry| 1,986 individuals | PGP000490 | Hatoum AS et al. Nat Ment Health (2023) | Reported Trait: Opioid Use Disorder | OR: 1.728 β: 0.5471 (0.062) | — | — | First 10 principal components, age, and sex | — |
| PPM018659 | PSS011056| European Ancestry| 1,986 individuals | PGP000490 | Hatoum AS et al. Nat Ment Health (2023) | Reported Trait: Cannabis Use Disorder | OR: 1.413 β: 0.3455 (0.057) | — | — | First 10 principal components, age, and sex | — |
| PPM018660 | PSS011056| European Ancestry| 1,986 individuals | PGP000490 | Hatoum AS et al. Nat Ment Health (2023) | Reported Trait: Cocaine Use Disorder | OR: 1.569 β: 0.451 (0.058) | — | — | First 10 principal components, age, and sex | — |
| PPM018661 | PSS011056| European Ancestry| 1,986 individuals | PGP000490 | Hatoum AS et al. Nat Ment Health (2023) | Reported Trait: Any Addiction | OR: 1.633 β: 0.49 (0.052) | — | — | First 10 principal components, age, and sex | — |
| PPM018662 | PSS011056| European Ancestry| 1,986 individuals | PGP000490 | Hatoum AS et al. Nat Ment Health (2023) | Reported Trait: Polysubstance use (2 or more) vs. no polysubstance use | OR: 1.721 β: 0.5427 (0.055) | — | — | First 10 principal components, age, and sex | — |
| PPM018663 | PSS011056| European Ancestry| 1,986 individuals | PGP000490 | Hatoum AS et al. Nat Ment Health (2023) | Reported Trait: Polysubstance use (2 or more) vs. Single substance use | OR: 1.445 β: 0.368 (0.082) | — | — | First 10 principal components, age, and sex | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
|
Additional Sample/Cohort Information
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|---|---|---|---|---|---|---|---|---|
| PSS011056 | — | — | 1,986 individuals | — | European | — | Yale-Penn | — |