| Publication Information (EuropePMC) | |
| Title | Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders. |
| PubMed ID | 37250466(Europe PMC) |
| doi | 10.1038/s44220-023-00034-y |
| Publication Date | March 22, 2023 |
| Journal | Nat Ment Health |
| Author(s) | Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak G, Jennings MV, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Tucker-Drob EM, Kranzler HR, Davis LK, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS003849 (PRSaddiction-rf) |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Addiction risk factors | substance-related disorder | 584,753 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003849/ScoringFiles/PGS003849.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM018660 | PGS003849 (PRSaddiction-rf) |
PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Cocaine Use Disorder | OR: 1.569 β: 0.451 (0.058) |
— | — | First 10 principal components, age, and sex | — |
| PPM018657 | PGS003849 (PRSaddiction-rf) |
PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Tobacco Use Disorder | OR: 1.643 β: 0.497 (0.054) |
— | — | First 10 principal components, age, and sex | — |
| PPM018658 | PGS003849 (PRSaddiction-rf) |
PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Opioid Use Disorder | OR: 1.728 β: 0.5471 (0.062) |
— | — | First 10 principal components, age, and sex | — |
| PPM018661 | PGS003849 (PRSaddiction-rf) |
PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Any Addiction | OR: 1.633 β: 0.49 (0.052) |
— | — | First 10 principal components, age, and sex | — |
| PPM018663 | PGS003849 (PRSaddiction-rf) |
PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Polysubstance use (2 or more) vs. Single substance use | OR: 1.445 β: 0.368 (0.082) |
— | — | First 10 principal components, age, and sex | — |
| PPM018656 | PGS003849 (PRSaddiction-rf) |
PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Alcohol Use Disorder | OR: 1.57 β: 0.451 (0.052) |
— | — | First 10 principal components, age, and sex | — |
| PPM018659 | PGS003849 (PRSaddiction-rf) |
PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Cannabis Use Disorder | OR: 1.413 β: 0.3455 (0.057) |
— | — | First 10 principal components, age, and sex | — |
| PPM018662 | PGS003849 (PRSaddiction-rf) |
PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Polysubstance use (2 or more) vs. no polysubstance use | OR: 1.721 β: 0.5427 (0.055) |
— | — | First 10 principal components, age, and sex | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011056 | — | — | 1,986 individuals | — | European | — | Yale-Penn | — |