Polygenic Score (PGS) ID: PGS003881

Predicted Trait
Reported Trait Triglyceride
Mapped Trait(s) triglyceride measurement (EFO_0004530)
Released in PGS Catalog: Nov. 1, 2023
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Score Details

Score Construction
PGS Name TG_lassosum2_ARB
Development Method
Name lassosum2
Parameters s:0.005_nl:20
Variants
Original Genome Build hg19
Number of Variants 54,623
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000501
Citation (link to publication) Shim I et al. Nature Communications (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 79.8%
East Asian: 8.9%
African: 6%
Hispanic or Latin American: 2.9%
South Asian: 2.5%
1,654,960 individuals (100%)
PGS Evaluation
Greater Middle Eastern: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90239661
Europe PMC: 34887591
 40,963 individuals South Asian NR
GWAS Catalog: GCST90239661
Europe PMC: 34887591
 48,057 individuals Hispanic or Latin American NR
GWAS Catalog: GCST90239661
Europe PMC: 34887591
 99,432 individuals African American or Afro-Caribbean, African unspecified NR
GWAS Catalog: GCST90239661
Europe PMC: 34887591
 146,492 individuals East Asian NR
GWAS Catalog: GCST90239661
Europe PMC: 34887591
 1,320,016 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018773 PSS011097|
Greater Middle Eastern Ancestry|
2,669 individuals
 PGP000501 |
Shim I et al. Nature Communications (2023)
 Reported Trait: Triglycerides β: 29.32 (2.31) — R²: 0.0857 age, sex, array version, and the first 10 principal components of ancestry —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011097 — — 2,669 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian)
(Arab)		 — NR N total after excluding missing values = 2,553