| Predicted Trait | |
| Reported Trait | Sitting height |
| Mapped Trait(s) | sitting height measurement (EFO_0011011) |
| Additional Trait Information | http://ipgs.mit.edu/tanigawakellis2023/INI20015 |
| Score Construction | |
| PGS Name | INI20015 |
| Development Method | |
| Name | snpnet |
| Parameters | inclusive PGS |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 44,543 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000502 |
| Citation (link to publication) | Tanigawa Y et al. AJHG (2023) |
| Ancestry Distribution | |
| Score Development/Training | |
| PGS Evaluation | |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
Phenotype Definitions & Methods
|
Age of Study Participants
|
Participant Follow-up Time
|
Additional Ancestry Description
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| — | 324,362 individuals | European, South Asian, African unspecified, Other admixed ancestry | UKB | — | — | — | European, South Asian, African unspecified, Other admixed ancestry | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM018799 | PSS011147| European Ancestry| 67,606 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Sitting height | — | — | R²: 0.56702 [0.56211, 0.57193] PGS R2 (no covariates): 0.13337 [0.12861, 0.13814] Incremental R2 (full-covars): 0.13166 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018800 | PSS011102| European Ancestry| 2,883 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Sitting height | — | — | R²: 0.56319 [0.53933, 0.58705] PGS R2 (no covariates): 0.14822 [0.12435, 0.17208] Incremental R2 (full-covars): 0.12786 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018801 | PSS011114| South Asian Ancestry| 1,448 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Sitting height | — | — | R²: 0.47658 [0.43993, 0.51322] PGS R2 (no covariates): 0.06813 [0.04346, 0.09279] Incremental R2 (full-covars): 0.05017 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018802 | PSS011159| African Ancestry| 1,191 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Sitting height | — | — | R²: 0.36181 [0.31873, 0.40489] PGS R2 (no covariates): 0.01877 [0.00368, 0.03386] Incremental R2 (full-covars): 0.00631 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
| PPM018803 | PSS011172| Multi-ancestry (excluding European)| 7,967 individuals | PGP000502 | Tanigawa Y et al. AJHG (2023) | Reported Trait: Sitting height | — | — | R²: 0.56286 [0.5485, 0.57722] PGS R2 (no covariates): 0.1462 [0.1319, 0.16049] Incremental R2 (full-covars): 0.10616 | age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS011102 | — | — | 2,883 individuals | — | European (non-white British ancestry) | — | UKB | — |
| PSS011114 | — | — | 1,448 individuals | — | South Asian | — | UKB | — |
| PSS011147 | — | — | 67,606 individuals | — | European (white British ancestry) | — | UKB | — |
| PSS011159 | — | — | 1,191 individuals | — | African unspecified | — | UKB | — |
| PSS011172 | — | — | 7,967 individuals | — | East Asian, Other admixed ancestry | East Asian, Other admixed ancestry | UKB | — |