Polygenic Score (PGS) ID: PGS003959

Predicted Trait
Reported Trait Obesity
Mapped Trait(s) obesity (EFO_0001073)
Released in PGS Catalog: Oct. 17, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRS940_obesity
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 940
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000507
Citation (link to publication) Liu X et al. Clin Nutr (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 67%
Not Reported: 33%
681,275 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST006900
Europe PMC: 30124842
224,849 individualsNRNR
GWAS Catalog: GCST006900
Europe PMC: 30124842
456,426 individualsEuropeanNR
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM019107PSS011184|
Multi-ancestry (including European)|
27,429 individuals
PGP000507 |
Liu X et al. Clin Nutr (2023)
Reported Trait: Obesityβ: 0.149 (0.028)——Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol c... onsumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baselineShow more—
PPM019108PSS011184|
Multi-ancestry (including European)|
27,429 individuals
PGP000507 |
Liu X et al. Clin Nutr (2023)
Reported Trait: Abdominal obesityβ: 0.078 (0.019)——Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol c... onsumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baselineShow more—
PPM019109PSS011184|
Multi-ancestry (including European)|
27,429 individuals
PGP000507 |
Liu X et al. Clin Nutr (2023)
Reported Trait: Body mass index increaseβ: 0.157 (0.013)——Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol c... onsumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baselineShow more—
PPM019110PSS011184|
Multi-ancestry (including European)|
27,429 individuals
PGP000507 |
Liu X et al. Clin Nutr (2023)
Reported Trait: Wasit circumference increaseβ: 0.213 (0.039)——Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol c... onsumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baselineShow more—
PPM019111PSS011184|
Multi-ancestry (including European)|
27,429 individuals
PGP000507 |
Liu X et al. Clin Nutr (2023)
Reported Trait: Body fat percentage increaseβ: 0.042 (0.021)——Age, sex, race, centres, education, Townsend deprivation index, household income, smoking, alcohol c... onsumption, physical activity, sleep pattern, energy intake, and BMI, WC or BF% at baselineShow more—
PPM019112PSS011184|
Multi-ancestry (including European)|
27,429 individuals
PGP000507 |
Liu X et al. Clin Nutr (2023)
Reported Trait: Obesity with sulfur microbial diet score——Hazard ratio (HR, Q4 sulphur microbial diet score and high PRS vs. Q1 sulphur microbial diet score and low PRS): 1.74 [1.33, 2.29]age, sex, race, centers, household income, Townsend deprivation index, smoking, alcohol consumption,...  physical activity, sleep pattern, energy intake and body mass index or waist circumstanceShow more—
PPM019113PSS011184|
Multi-ancestry (including European)|
27,429 individuals
PGP000507 |
Liu X et al. Clin Nutr (2023)
Reported Trait: Abdominal obesity with sulfur microbial diet score——Hazard ratio (HR, Q4 sulphur microbial diet score and high PRS vs. Q1 sulphur microbial diet score and low PRS): 1.41 [1.17, 1.71]age, sex, race, centers, household income, Townsend deprivation index, smoking, alcohol consumption,...  physical activity, sleep pattern, energy intake and body mass index or waist circumstanceShow more—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011184——27,429 individuals,
47.0 % Male samples
Mean = 55.3 years
Sd = 7.6 years		European, Not reported—UKB—
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