Predicted Trait | |
Reported Trait | Inflammatory bowel disease (IBD) |
Mapped Trait(s) | inflammatory bowel disease (EFO_0003767) |
Score Construction | |
PGS Name | sbayesr.auto.GCST004131.IBD |
Development Method | |
Name | SBayesR-auto |
Parameters | auto with --robust |
Variants | |
Original Genome Build | GRCh38 |
Number of Variants | 912,746 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000517 |
Citation (link to publication) | Monti R et al. Am J Hum Genet (2024) |
Ancestry Distribution | |
Source of Variant Associations (GWAS) | |
Score Development/Training | European: 100% 5,340 individuals (100%) |
PGS Evaluation | European: 66.7% South Asian: 33.3% 6 Sample Sets |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
GWAS Catalog: GCST004131 Europe PMC: 28067908 |
59,957 individuals | NR, European | NR |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 5,340 individuals | European | UKB | — | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM019245 | PSS011220| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Inflammatory bowel disease | OR: 1.33765 [1.28124872, 1.39652797] β: 0.29091 [0.24783517, 0.33398913] |
AUROC: 0.57881 [0.56619924, 0.59141916] | R²: 0.01327 [0.00951776, 0.01750544] | 0 | beta = log(or)/sd_pgs |
PPM019247 | PSS011244| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Inflammatory bowel disease | OR: 1.8584 [1.69570378, 2.03671362] β: 0.61972 [0.52809786, 0.71133754] |
AUROC: 0.67037 [0.64541857, 0.69532926] | R²: 0.05737 [0.04034006, 0.0772097] | 0 | beta = log(or)/sd_pgs |
PPM019248 | PSS011260| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Inflammatory bowel disease | OR: 1.53371 [1.46233061, 1.60856652] β: 0.42769 [0.38003147, 0.47534342] |
AUROC: 0.61478 [0.60105563, 0.62849573] | R²: 0.02843 [0.02204494, 0.03592548] | 0 | beta = log(or)/sd_pgs |
PPM019249 | PSS011288| South Asian Ancestry| 9,326 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Inflammatory bowel disease | OR: 1.68556 [1.44596698, 1.96485528] β: 0.5221 [0.36877829, 0.67541859] |
AUROC: 0.64539 [0.6020922, 0.68868922] | R²: 0.04075 [0.01870039, 0.06894677] | 0 | beta = log(or)/sd_pgs |
PPM019250 | PSS011273| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Inflammatory bowel disease | OR: 1.91118 [1.80890361, 2.01924795] β: 0.64772 [0.59272092, 0.70272514] |
AUROC: 0.67763 [0.6631321, 0.69213434] | R²: 0.06425 [0.05393186, 0.07625535] | 0 | beta = log(or)/sd_pgs |
PPM019246 | PSS011231| European Ancestry| 396,819 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: Inflammatory bowel disease | OR: 1.982 [1.93724169, 2.02779924] β: 0.68411 [0.66126515, 0.70695109] |
AUROC: 0.68425 [0.67836828, 0.6901266] | R²: 0.0719 [0.06717405, 0.07701924] | 0 | beta = log(or)/sd_pgs |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011273 | — | — | [
|
— | European | — | UKB | — |
PSS011244 | — | — | [
|
— | South Asian | — | G&H | — |
PSS011220 | — | — | [
|
— | European | — | EB | — |
PSS011288 | — | — | [
|
— | South Asian | — | UKB | — |
PSS011260 | — | — | [
|
— | European | — | HUNT | — |
PSS011231 | K11_IBD_STRICT, ICD10: K50|K51, ICD9: 555|556 | — | [
|
— | European | — | FinnGen | — |