Polygenic Score (PGS) ID: PGS004231

Predicted Trait
Reported Trait Systolic blood pressure
Mapped Trait(s) systolic blood pressure (EFO_0006335)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name PRS732_SBP
Development Method
Name Genome-wide significant SNPs
Parameters r2 <0.1, p<5e-08
Variants
Original Genome Build GRCh37
Number of Variants 732
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000529
Citation (link to publication) Acosta JN et al. Neurology (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
757,601 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006624
Europe PMC: 30224653
 757,601 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020229 PSS011310|
European Ancestry|
1,750 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Systolic blood pressure — — Beta (beta, top PRS quintile vs bottom PRS quintile): 3.62 (1.39) — —
PPM020230 PSS011310|
European Ancestry|
1,750 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.27 [1.3, 4.1] — —
PPM020232 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Systolic blood pressure in all stroke — — Beta (beta, top PRS quintile vs bottom PRS quintile): 5.97 (0.76) age, sex, and vascular risk factors —
PPM020233 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Uncontrolled blood pressure in all stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.71 [1.45, 2.03] age, sex, and vascular risk factors —
PPM020234 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure in all stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.25 [1.59, 3.25] age, sex, and vascular risk factors —
PPM020238 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Systolic blood pressure in Ischemic stroke — — Beta (beta, top PRS quintile vs bottom PRS quintile): 4.89 (1.51) age, sex, and vascular risk factors —
PPM020240 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure in Ischemic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.65 [1.39, 5.35] age, sex, and vascular risk factors —
PPM020244 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Systolic blood pressure in Hemorrhagic stroke — — Beta (beta, top PRS quintile vs bottom PRS quintile): 4.84 (1.91) age, sex, and vascular risk factors —
PPM020245 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Uncontrolled blood pressure in Hemorrhagic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 2.17 [1.41, 3.36] age, sex, and vascular risk factors —
PPM020246 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Resistant blood pressure in Hemorrhagic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.77 [0.69, 4.97] age, sex, and vascular risk factors —
PPM020239 PSS011309|
European Ancestry|
408,475 individuals
 PGP000529 |
Acosta JN et al. Neurology (2023)
 Reported Trait: Uncontrolled blood pressure in Ischemic stroke — — Odds ratio (OR, top PRS quintile vs bottom PRS quintile): 1.73 [1.23, 2.43] age, sex, and vascular risk factors —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011309 — — 408,475 individuals,
59.0 % Male samples
 Mean = 61.0 years
Sd = 7.0 years		 European — UKB —
PSS011310 — — 1,750 individuals,
65.0 % Male samples
 Mean = 68.0 years
Sd = 11.0 years		 European — VISP —