Polygenic Score (PGS) ID: PGS004234

Predicted Trait
Reported Trait Hypertension
Mapped Trait(s) hypertension (EFO_0000537)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name HTN_PAN-UKBB
Development Method
Name PRSice-2
Parameters R2 = 0.1, 0.2 and 0.3, CV-PRS
Variants
Original Genome Build GRCh38
Number of Variants 234,228
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000531
Citation (link to publication) Kurniansyah N et al. Nat Commun (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • African
  • Hispanic or Latin American
  • European
  • South Asian
  • Additional Asian Ancestries
  • Greater Middle Eastern
  • East Asian
451,894 individuals (100%)
Score Development/Training
Hispanic or Latin American: 40.6%
African: 27.2%
European: 24.3%
Not Reported: 6.5%
Additional Asian Ancestries: 1.5%
10,314 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • African
  • Hispanic or Latin American
  • Additional Asian Ancestries
  • European
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
[
  • 126,196 cases
  • , 325,698 controls
]
 African unspecified,Hispanic or Latin American,European,South Asian,Central Asian,Greater Middle Eastern (Middle Eastern, North African or Persian),East Asian UKB
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 2,803 individuals,
33.5 % Male samples
 African American or Afro-Caribbean BioMe — Mean = 55.9 years
Sd = 12.5 years		 — — —
— 151 individuals,
44.4 % Male samples
 Asian unspecified BioMe — Mean = 53.14 years
Sd = 13.52 years		 — — —
— 2,506 individuals,
52.2 % Male samples
 European BioMe — Mean = 60.42 years
Sd = 13.96 years		 — — —
— 4,187 individuals,
37.5 % Male samples
 Hispanic or Latin American BioMe — Mean = 57.72 years
Sd = 13.18 years		 — — —
— 667 individuals,
57.9 % Male samples
 Not reported BioMe — Mean = 57.51 years
Sd = 13.1 years		 — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020253 PSS011312|
Multi-ancestry (including European)|
39,035 individuals
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Reported Trait: Prevelant hypertension — AUROC: 0.763 [0.75, 0.775] — sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011312 — — 8,822 individuals,
31.9 % Male samples
 — African American or Afro-Caribbean — 6 cohorts
  • ARIC
  • ,CHS
  • ,GENOA
  • ,JHS
  • ,MESA
  • ,WHI
 —
PSS011312 — — 6,718 individuals,
38.0 % Male samples
 — Hispanic or Latin American — 6 cohorts
  • CHS
  • ,FHS
  • ,HCHS
  • ,MESA
  • ,SOL
  • ,WHI
 —
PSS011312 — — 794 individuals,
37.9 % Male samples
 — Asian unspecified — MESA, WHI —
PSS011312 — — 22,701 individuals,
27.8 % Male samples
 — European — ARIC, CHS, FHS, MESA, WHI —