PGS Publication: PGP000531

Publication Information (EuropePMC)
Title A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood.
PubMed ID 35729114(Europe PMC)
doi 10.1038/s41467-022-31080-2
Publication Date June 21, 2022
Journal Nat Commun
Author(s) Kurniansyah N, Goodman MO, Kelly TN, Elfassy T, Wiggins KL, Bis JC, Guo X, Palmas W, Taylor KD, Lin ... HJ, Haessler J, Gao Y, Shimbo D, Smith JA, Yu B, Feofanova EV, Smit RAJ, Wang Z, Hwang SJ, Liu S, Wassertheil-Smoller S, Manson JE, Lloyd-Jones DM, Rich SS, Loos RJF, Redline S, Correa A, Kooperberg C, Fornage M, Kaplan RC, Psaty BM, Rotter JI, Arnett DK, Morrison AC, Franceschini N, Levy D, NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Sofer T.Show more
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

JSONXMLCSVTXTMS-Excel
Loading, please wait
Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS004233
(DBP_MVP)
PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
Diastolic blood pressurediastolic blood pressure149,559
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004233/ScoringFiles/PGS004233.txt.gz
PGS004234
(HTN_PAN-UKBB)
PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
Hypertensionhypertension234,228
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004234/ScoringFiles/PGS004234.txt.gz
PGS004235
(SBP_MVP)
PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
Systolic blood pressuresystolic blood pressure24,807
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004235/ScoringFiles/PGS004235.txt.gz
PGS004236
(HTN_Unweighted_PRSsum)
PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
Hypertensionhypertension398,805
G
D
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004236/ScoringFiles/PGS004236.txt.gz
Showing 1 to 4 of 4 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM020252PGS004233
(DBP_MVP)
PSS011312|
Multi-ancestry (including European)|
39,035 individuals
PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
Reported Trait: Prevelant hypertension—AUROC: 0.754 [0.741, 0.767]—sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal ... componentsShow more—
PPM020253PGS004234
(HTN_PAN-UKBB)
PSS011312|
Multi-ancestry (including European)|
39,035 individuals
PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
Reported Trait: Prevelant hypertension—AUROC: 0.763 [0.75, 0.775]—sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal ... componentsShow more—
PPM020254PGS004235
(SBP_MVP)
PSS011312|
Multi-ancestry (including European)|
39,035 individuals
PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
Reported Trait: Prevelant hypertension—AUROC: 0.757 [0.744, 0.771]—sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal ... componentsShow more—
PPM020255PGS004236
(HTN_Unweighted_PRSsum)
PSS011312|
Multi-ancestry (including European)|
39,035 individuals
PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
Reported Trait: Prevelant hypertensionOR: 2.1 [1.99, 2.21]AUROC: 0.764 [0.751, 0.777]—sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal ... componentsShow morePRSsum based on selected CV-PRS (which summed the CV-PRS from the three phenotypes).
PPM020256PGS004236
(HTN_Unweighted_PRSsum)
PSS011312|
Multi-ancestry (including European)|
39,035 individuals
PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
Reported Trait: New-onset hypertension (normotensive)OR: 1.72 [1.55, 1.91]AUROC: 0.656—sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal ... componentsShow morePRSsum based on selected CV-PRS (which summed the CV-PRS from the three phenotypes).
PPM020257PGS004236
(HTN_Unweighted_PRSsum)
PSS011312|
Multi-ancestry (including European)|
39,035 individuals
PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
Reported Trait: New-onset hypertension (elevated)OR: 1.48 [1.27, 1.71]AUROC: 0.582—sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal ... componentsShow morePRSsum based on selected CV-PRS (which summed the CV-PRS from the three phenotypes).
Showing 1 to 6 of 6 rows

Evaluated Samples

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011312——8,822 individuals,
31.9 % Male samples
—African American or Afro-Caribbean—6 cohorts
  • ARIC
  • ,CHS
  • ,GENOA
  • ,JHS
  • ,MESA
  • ,WHI
—
PSS011312——6,718 individuals,
38.0 % Male samples
—Hispanic or Latin American—6 cohorts
  • CHS
  • ,FHS
  • ,HCHS
  • ,MESA
  • ,SOL
  • ,WHI
—
PSS011312——794 individuals,
37.9 % Male samples
—Asian unspecified—MESA, WHI—
PSS011312——22,701 individuals,
27.8 % Male samples
—European—ARIC, CHS, FHS, MESA, WHI—
Showing 1 to 4 of 4 rows