PGS Catalog - PGS004248 / Non-Hodgkin's lymphoma (Polygenic Score)

Polygenic Score (PGS) ID: PGS004248

Predicted Trait
Reported Trait	Non-Hodgkin's lymphoma
Mapped Trait(s)	non-Hodgkins lymphoma (EFO_0005952)

Released in PGS Catalog: Dec. 15, 2023

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Terms and Licenses

PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name	PRS20_nhl
Development Method
Name	PRSice-2
Parameters	p = 5E-8, r² = 0.1
Variants
Original Genome Build	NR
Number of Variants	20
Effect Weight Type	log(OR)

PGS Source
PGS Catalog Publication (PGP) ID	PGP000542
Citation (link to publication)	Kim ES et al. NPJ Precis Oncol (2023)

Ancestry Distribution
Source of Variant Associations (GWAS)	European: 100% 37,455 individuals (100%)
PGS Evaluation	European: 100% 2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)

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Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)
GWAS Catalog: GCST002073 Europe PMC: 23770605	8,400 individuals	European	NR
GWAS Catalog: GCST002636 Europe PMC: 25261932	11,523 individuals	European	NR
GWAS Catalog: GCST002643 Europe PMC: 25279986	10,486 individuals	European	NR
GWAS Catalog: GCST002742 Europe PMC: 25569183	7,046 individuals	European	NR

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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM020305	PSS011328\| European Ancestry\| 133,830 individuals	PGP000542 \| Kim ES et al. NPJ Precis Oncol (2023)	Reported Trait: Non-Hodgkin's lymphoma	HR: 1.16 [1.03, 1.3]	—	—	first 10 genetic principal components	—
PPM020313	PSS011329\| European Ancestry\| 115,207 individuals	PGP000542 \| Kim ES et al. NPJ Precis Oncol (2023)	Reported Trait: Non-Hodgkin's lymphoma	HR: 1.22 [1.1, 1.36]	—	—	first 10 genetic principal components	—

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Evaluated Samples

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PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS011328	—	—	133,830 individuals, 0.0 % Male samples	—	European (British)	—	UKB	—
PSS011329	—	—	115,207 individuals, 100.0 % Male samples	—	European (British)	—	UKB	—

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