PGS Publication: PGP000542

Publication Information (EuropePMC)
Title Potential utility of risk stratification for multicancer screening with liquid biopsy tests.
PubMed ID 37087533(Europe PMC)
doi 10.1038/s41698-023-00377-w
Publication Date April 22, 2023
Journal NPJ Precis Oncol
Author(s) Kim ES, Scharpf RB, Garcia-Closas M, Visvanathan K, Velculescu VE, Chatterjee N.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004245
(PRS12_kidney)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Kidney cancer renal cell carcinoma 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004245/ScoringFiles/PGS004245.txt.gz
PGS004246
(PRS43_lung)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Lung cancer lung carcinoma 43
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004246/ScoringFiles/PGS004246.txt.gz
PGS004250
(PRS19_pancreas)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Pancreatic cancer pancreatic carcinoma 19
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004250/ScoringFiles/PGS004250.txt.gz
PGS004249
(PRS25_ovary)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Ovarian cancer ovarian carcinoma 25
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004249/ScoringFiles/PGS004249.txt.gz
PGS004251
(PRS125_prostate)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Prostate cancer prostate carcinoma 125
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004251/ScoringFiles/PGS004251.txt.gz
PGS004247
(PRS65_melanoma)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Melanoma cutaneous melanoma 65
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004247/ScoringFiles/PGS004247.txt.gz
PGS004248
(PRS20_nhl)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Non-Hodgkin's lymphoma non-Hodgkins lymphoma 20
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004248/ScoringFiles/PGS004248.txt.gz
PGS004242
(PRS306_breast)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Breast cancer breast carcinoma 306
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004242/ScoringFiles/PGS004242.txt.gz
PGS004244
(PRS16_endometrium)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Endometrial cancer endometrial carcinoma 16
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004244/ScoringFiles/PGS004244.txt.gz
PGS004241
(PRS12_bladder)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Bladder cancer urinary bladder carcinoma 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004241/ScoringFiles/PGS004241.txt.gz
PGS004243
(PRS67_colorectum)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Colorectal cancer colorectal carcinoma 67
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004243/ScoringFiles/PGS004243.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020311 PGS004246
(PRS43_lung)
 PSS011329|
European Ancestry|
115,207 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Lung cancer HR: 1.2 [1.11, 1.3] — — first 10 genetic principal components —
PPM020312 PGS004247
(PRS65_melanoma)
 PSS011329|
European Ancestry|
115,207 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Melanoma HR: 1.71 [1.55, 1.89] — — first 10 genetic principal components —
PPM020298 PGS004241
(PRS12_bladder)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Bladder cancer HR: 1.41 [1.09, 1.83] — — first 10 genetic principal components —
PPM020299 PGS004242
(PRS306_breast)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Breast cancer HR: 1.58 [1.53, 1.64] — — first 10 genetic principal components —
PPM020300 PGS004243
(PRS67_colorectum)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Colorectal cancer HR: 1.49 [1.39, 1.61] — — first 10 genetic principal components —
PPM020301 PGS004244
(PRS16_endometrium)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Endometrial cancer HR: 1.25 [1.14, 1.36] — — first 10 genetic principal components —
PPM020302 PGS004245
(PRS12_kidney)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Kidney cancer HR: 1.22 [1.02, 1.45] — — first 10 genetic principal components —
PPM020303 PGS004246
(PRS43_lung)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Lung cancer HR: 1.18 [1.08, 1.28] — — first 10 genetic principal components —
PPM020304 PGS004247
(PRS65_melanoma)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Melanoma HR: 1.78 [1.62, 1.96] — — first 10 genetic principal components —
PPM020305 PGS004248
(PRS20_nhl)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Non-Hodgkin's lymphoma HR: 1.16 [1.03, 1.3] — — first 10 genetic principal components —
PPM020306 PGS004249
(PRS25_ovary)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Ovarian cancer HR: 1.16 [1.03, 1.31] — — first 10 genetic principal components —
PPM020307 PGS004250
(PRS19_pancreas)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Pancreatic cancer HR: 1.37 [1.16, 1.61] — — first 10 genetic principal components —
PPM020308 PGS004241
(PRS12_bladder)
 PSS011329|
European Ancestry|
115,207 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Bladder cancer HR: 1.28 [1.12, 1.48] — — first 10 genetic principal components —
PPM020309 PGS004243
(PRS67_colorectum)
 PSS011329|
European Ancestry|
115,207 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Colorectal cancer HR: 1.51 [1.42, 1.61] — — first 10 genetic principal components —
PPM020310 PGS004245
(PRS12_kidney)
 PSS011329|
European Ancestry|
115,207 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Kidney cancer HR: 1.25 [1.1, 1.41] — — first 10 genetic principal components —
PPM020313 PGS004248
(PRS20_nhl)
 PSS011329|
European Ancestry|
115,207 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Non-Hodgkin's lymphoma HR: 1.22 [1.1, 1.36] — — first 10 genetic principal components —
PPM020314 PGS004250
(PRS19_pancreas)
 PSS011329|
European Ancestry|
115,207 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Pancreatic cancer HR: 1.39 [1.2, 1.61] — — first 10 genetic principal components —
PPM020315 PGS004251
(PRS125_prostate)
 PSS011329|
European Ancestry|
115,207 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Prostate cancer HR: 1.78 [1.72, 1.85] — — first 10 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011328 — — 133,830 individuals,
0.0 % Male samples
 — European
(British)		 — UKB —
PSS011329 — — 115,207 individuals,
100.0 % Male samples
 — European
(British)		 — UKB —