PGS Publication: PGP000542

Publication Information (EuropePMC)
Title Potential utility of risk stratification for multicancer screening with liquid biopsy tests.
PubMed ID 37087533(Europe PMC)
doi 10.1038/s41698-023-00377-w
Publication Date April 22, 2023
Journal NPJ Precis Oncol
Author(s) Kim ES, Scharpf RB, Garcia-Closas M, Visvanathan K, Velculescu VE, Chatterjee N.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS004241
(PRS12_bladder)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Bladder cancerurinary bladder carcinoma12
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004241/ScoringFiles/PGS004241.txt.gz
PGS004242
(PRS306_breast)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Breast cancerbreast carcinoma306
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004242/ScoringFiles/PGS004242.txt.gz
PGS004243
(PRS67_colorectum)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Colorectal cancercolorectal carcinoma67
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004243/ScoringFiles/PGS004243.txt.gz
PGS004244
(PRS16_endometrium)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Endometrial cancerendometrial carcinoma16
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004244/ScoringFiles/PGS004244.txt.gz
PGS004245
(PRS12_kidney)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Kidney cancerrenal cell carcinoma12
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004245/ScoringFiles/PGS004245.txt.gz
PGS004246
(PRS43_lung)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Lung cancerlung carcinoma43
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004246/ScoringFiles/PGS004246.txt.gz
PGS004247
(PRS65_melanoma)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Melanomacutaneous melanoma65
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004247/ScoringFiles/PGS004247.txt.gz
PGS004248
(PRS20_nhl)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Non-Hodgkin's lymphomanon-Hodgkins lymphoma20
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004248/ScoringFiles/PGS004248.txt.gz
PGS004249
(PRS25_ovary)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Ovarian cancerovarian carcinoma25
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004249/ScoringFiles/PGS004249.txt.gz
PGS004250
(PRS19_pancreas)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Pancreatic cancerpancreatic carcinoma19
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004250/ScoringFiles/PGS004250.txt.gz
PGS004251
(PRS125_prostate)
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Prostate cancerprostate carcinoma125
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004251/ScoringFiles/PGS004251.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM020298PGS004241
(PRS12_bladder)
PSS011328|
European Ancestry|
133,830 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Bladder cancerHR: 1.41 [1.09, 1.83]——first 10 genetic principal components—
PPM020299PGS004242
(PRS306_breast)
PSS011328|
European Ancestry|
133,830 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Breast cancerHR: 1.58 [1.53, 1.64]——first 10 genetic principal components—
PPM020300PGS004243
(PRS67_colorectum)
PSS011328|
European Ancestry|
133,830 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Colorectal cancerHR: 1.49 [1.39, 1.61]——first 10 genetic principal components—
PPM020301PGS004244
(PRS16_endometrium)
PSS011328|
European Ancestry|
133,830 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Endometrial cancerHR: 1.25 [1.14, 1.36]——first 10 genetic principal components—
PPM020302PGS004245
(PRS12_kidney)
PSS011328|
European Ancestry|
133,830 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Kidney cancerHR: 1.22 [1.02, 1.45]——first 10 genetic principal components—
PPM020303PGS004246
(PRS43_lung)
PSS011328|
European Ancestry|
133,830 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Lung cancerHR: 1.18 [1.08, 1.28]——first 10 genetic principal components—
PPM020304PGS004247
(PRS65_melanoma)
PSS011328|
European Ancestry|
133,830 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: MelanomaHR: 1.78 [1.62, 1.96]——first 10 genetic principal components—
PPM020305PGS004248
(PRS20_nhl)
PSS011328|
European Ancestry|
133,830 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Non-Hodgkin's lymphomaHR: 1.16 [1.03, 1.3]——first 10 genetic principal components—
PPM020306PGS004249
(PRS25_ovary)
PSS011328|
European Ancestry|
133,830 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Ovarian cancerHR: 1.16 [1.03, 1.31]——first 10 genetic principal components—
PPM020307PGS004250
(PRS19_pancreas)
PSS011328|
European Ancestry|
133,830 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Pancreatic cancerHR: 1.37 [1.16, 1.61]——first 10 genetic principal components—
PPM020308PGS004241
(PRS12_bladder)
PSS011329|
European Ancestry|
115,207 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Bladder cancerHR: 1.28 [1.12, 1.48]——first 10 genetic principal components—
PPM020309PGS004243
(PRS67_colorectum)
PSS011329|
European Ancestry|
115,207 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Colorectal cancerHR: 1.51 [1.42, 1.61]——first 10 genetic principal components—
PPM020310PGS004245
(PRS12_kidney)
PSS011329|
European Ancestry|
115,207 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Kidney cancerHR: 1.25 [1.1, 1.41]——first 10 genetic principal components—
PPM020311PGS004246
(PRS43_lung)
PSS011329|
European Ancestry|
115,207 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: Lung cancerHR: 1.2 [1.11, 1.3]——first 10 genetic principal components—
PPM020312PGS004247
(PRS65_melanoma)
PSS011329|
European Ancestry|
115,207 individuals
PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
Reported Trait: MelanomaHR: 1.71 [1.55, 1.89]——first 10 genetic principal components—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011328——133,830 individuals,
0.0 % Male samples
—European
(British)		—UKB—
PSS011329——115,207 individuals,
100.0 % Male samples
—European
(British)		—UKB—
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