Trait: ovarian carcinoma

Experimental Factor Ontology (EFO) Information
Identifier EFO_0001075
Description A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002 [NCIT: C4908]
Trait category
Cancer
Synonyms 8 synonyms
  • EOS
  • carcinoma of ovary
  • carcinoma of the ovary
  • epithelial ovarian cancer
  • ovarian cancer
  • ovarian carcinoma
  • ovarian epithelial cancer
  • ovary carcinoma
Mapped terms 7 mapped terms
  • DOID:4001
  • EFO:0001075
  • MEDGEN:1648335
  • MONDO:0005140
  • NCIT:C4908
  • OMIM:167000
  • UMLS:C4721610
Child trait(s) 2 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "ovarian carcinoma" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000048
(OCPRS_Overall)
 PGP000033 |
Kuchenbaecker KB et al. J Natl Cancer Inst (2017)
 Ovarian cancer ovarian carcinoma 17
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000048/ScoringFiles/PGS000048.txt.gz
PGS000068
(PRS_EOC)
 PGP000048 |
Yang X et al. J Med Genet (2018)
 Epithelial ovarian cancer ovarian carcinoma 15
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000068/ScoringFiles/PGS000068.txt.gz
PGS000069
(PRS_sEOC)
 PGP000048 |
Yang X et al. J Med Genet (2018)
 Serous epithelial ovarian cancer ovarian serous carcinoma 15
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000069/ScoringFiles/PGS000069.txt.gz
PGS000082
(CC_Ovary)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Ovarian cancer ovarian carcinoma 36
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000082/ScoringFiles/PGS000082.txt.gz
PGS000158
(cGRS_Ovarian)
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Ovarian cancer ovarian carcinoma 11
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000158/ScoringFiles/PGS000158.txt.gz
PGS000351
(PRS_EOC)
 PGP000117 |
Barnes DR et al. Genet Med (2020)
 Invasive epithelial ovarian cancer ovarian carcinoma 30
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000351/ScoringFiles/PGS000351.txt.gz
PGS000352
(PRS_HGS)
 PGP000117 |
Barnes DR et al. Genet Med (2020)
 High grade serous ovarian cancer high grade ovarian serous adenocarcinoma 22
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000352/ScoringFiles/PGS000352.txt.gz
PGS000724
(PRS_Ovary)
 PGP000135 |
Jia G et al. JNCI Cancer Spectr (2020)
 Epithelial ovarian cancer ovarian carcinoma 31
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000724/ScoringFiles/PGS000724.txt.gz
PGS000793
(CC_Ovary_IV)
 PGP000186 |
Kachuri L et al. Nat Commun (2020)
 Ovarian cancer ovarian carcinoma 36
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000793/ScoringFiles/PGS000793.txt.gz
PGS002250
(PRS_S4)
 PGP000277 |
Dareng EO et al. Eur J Hum Genet (2022)
 Epithelial ovarian cancer ovarian carcinoma 27,240
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002250/ScoringFiles/PGS002250.txt.gz
PGS003385
(best_OV)
 PGP000413 |
Namba S et al. Cancer Res (2022)
 Ovarian serous carcinoma ovarian serous carcinoma 144,810
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003385/ScoringFiles/PGS003385.txt.gz
PGS003394
(PRS_Stepwise)
 PGP000277 |
Dareng EO et al. Eur J Hum Genet (2022)
 Epithelial ovarian cancer ovarian carcinoma 36
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003394/ScoringFiles/PGS003394.txt.gz
PGS003741
(PRS28_OC)
 PGP000470 |
Xin J et al. EBioMedicine (2023)
 Ovarian cancer ovarian carcinoma 28
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003741/ScoringFiles/PGS003741.txt.gz
PGS003754
(PRS22_OCstepwise)
 PGP000474 |
Hurwitz LM et al. JAMA Netw Open (2023)
 Nonmucinous Epithelial Ovarian Cancer ovarian carcinoma 22
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003754/ScoringFiles/PGS003754.txt.gz
PGS004249
(PRS25_ovary)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Ovarian cancer ovarian carcinoma 25
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004249/ScoringFiles/PGS004249.txt.gz
PGS004692
(ovarian_cancer)
 PGP000596 |
Hu J et al. JNCI Cancer Spectr (2024)
 Ovarian cancer ovarian carcinoma 6,385,666
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004692/ScoringFiles/PGS004692.txt.gz
PGS005086
(PGS64518_OC)
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Non-mucinous epithelial ovarian cancer ovarian carcinoma 64,518
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005086/ScoringFiles/PGS005086.txt.gz
PGS005087
(PGS5957_OC)
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Non-mucinous epithelial ovarian cancer ovarian carcinoma 5,957
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005087/ScoringFiles/PGS005087.txt.gz
PGS005088
(PGS3448_OC)
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Non-mucinous epithelial ovarian cancer ovarian carcinoma 3,448
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005088/ScoringFiles/PGS005088.txt.gz
PGS005089
(PGS400_OC)
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Non-mucinous epithelial ovarian cancer ovarian carcinoma 400
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005089/ScoringFiles/PGS005089.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000112 PGS000048
(OCPRS_Overall)
 PSS000072|
European Ancestry|
15,252 individuals
 PGP000033 |
Kuchenbaecker KB et al. J Natl Cancer Inst (2017)
 Reported Trait: Ovarian cancer in BRCA1 mutation carriers HR: 1.28 [1.22, 1.34] C-index: 0.579 [0.559, 0.6] — Country, birth year —
PPM000113 PGS000048
(OCPRS_Overall)
 PSS000073|
European Ancestry|
8,211 individuals
 PGP000033 |
Kuchenbaecker KB et al. J Natl Cancer Inst (2017)
 Reported Trait: Ovarian cancer in BRCA2 mutation carriers HR: 1.49 [1.34, 1.65] C-index: 0.628 [0.592, 0.665] — Country, birth year —
PPM000188 PGS000068
(PRS_EOC)
 PSS000108|
European Ancestry|
4,095 individuals
 PGP000048 |
Yang X et al. J Med Genet (2018)
 Reported Trait: all invasive epithelial ovarian cancer OR: 1.32 [1.21, 1.45] C-index: 0.58 [0.55, 0.6] — — —
PPM000189 PGS000069
(PRS_sEOC)
 PSS000108|
European Ancestry|
4,095 individuals
 PGP000048 |
Yang X et al. J Med Genet (2018)
 Reported Trait: serous epithelial ovarian cancer OR: 1.43 [1.29, 1.58] C-index: 0.6 [0.57, 0.63] — — —
PPM000202 PGS000082
(CC_Ovary)
 PSS000121|
European Ancestry|
220,909 individuals
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Reported Trait: Ovarian cancer OR: 1.14 [1.08, 1.2] — — Genotyping reagent kit (GERA cohort only), genotyping array (UK Biobank only), age, 10 PCs. Results from meta-analysis of GERA and UKB
PPM002048 PGS000082
(CC_Ovary)
 PSS001021|
European Ancestry|
211,958 individuals
 PGP000186 |
Kachuri L et al. Nat Commun (2020)
|Ext.		 Reported Trait: Incident ovarian cancer HR: 1.13 [1.04, 1.24] AUROC: 0.656
C-index: 0.655 (0.015)		 — Age at assessment, family history of breast cancer, genotyping array, PCs(1-15), parity ( ≥1 live birth vs. none), body mass index, Menopausal status (pre-menopausal vs. post-menopausal vs. unknown or hysterectomy), ever used hormone replacement therapy, oral contraceptive use (never used (0) vs. <20 years vs. ≥20 years), BMI*menopausal status C-index calculated as a weighted average between 1 and 5 years and AUC at 5 years.
PPM017174 PGS000082
(CC_Ovary)
 PSS010149|
European Ancestry|
315 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Ovarian cancer HR: 1.09 [0.97, 1.21] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —
PPM000489 PGS000158
(cGRS_Ovarian)
 PSS000278|
European Ancestry|
7,551 individuals
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Reported Trait: Ovarian cancer — — Odds Ratio (OR; high vs. average risk groups): 1.63 [1.3, 2.06] — —
PPM000478 PGS000158
(cGRS_Ovarian)
 PSS000278|
European Ancestry|
7,551 individuals
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Reported Trait: Ovarian cancer — — Mean realative risk: 1.12 [1.08, 1.16]
Wilcoxon test (case vs. control) p-value: 0.00015		 — —
PPM001030 PGS000351
(PRS_EOC)
 PSS000524|
European Ancestry|
18,935 individuals
 PGP000117 |
Barnes DR et al. Genet Med (2020)
 Reported Trait: Ovarian cancer in BRCA1 carriers HR: 1.31 [1.24, 1.39] — — birth cohort, PCs(1-4) of ancestry, family history in first- and second-degree relatives —
PPM001031 PGS000351
(PRS_EOC)
 PSS000528|
European Ancestry|
12,339 individuals
 PGP000117 |
Barnes DR et al. Genet Med (2020)
 Reported Trait: Ovarian cancer in BRCA2 carriers HR: 1.42 [1.28, 1.58] — — birth cohort, PCs(1-4) of ancestry, family history in first- and second-degree relatives —
PPM001032 PGS000352
(PRS_HGS)
 PSS000524|
European Ancestry|
18,935 individuals
 PGP000117 |
Barnes DR et al. Genet Med (2020)
 Reported Trait: Ovarian cancer in BRCA1 carriers HR: 1.32 [1.25, 1.4] — — birth cohort, PCs(1-4) of ancestry, family history in first- and second-degree relatives —
PPM001033 PGS000352
(PRS_HGS)
 PSS000528|
European Ancestry|
12,339 individuals
 PGP000117 |
Barnes DR et al. Genet Med (2020)
 Reported Trait: Ovarian cancer in BRCA2 carriers HR: 1.43 [1.29, 1.59] — — birth cohort, PCs(1-4) of ancestry, family history in first- and second-degree relatives —
PPM001036 PGS000352
(PRS_HGS)
 PSS000530|
European Ancestry|
3,152 individuals
 PGP000117 |
Barnes DR et al. Genet Med (2020)
 Reported Trait: Incident ovarian cancer in BRCA1 carriers HR: 1.28 [1.06, 1.55] — — family history of the appropriate cancer in first- and second-degree relatives —
PPM001037 PGS000352
(PRS_HGS)
 PSS000532|
European Ancestry|
2,495 individuals
 PGP000117 |
Barnes DR et al. Genet Med (2020)
 Reported Trait: Incident ovarian cancer in BRCA2 carriers HR: 1.45 [1.13, 1.86] — — family history of the appropriate cancer in first- and second-degree relatives —
PPM001654 PGS000724
(PRS_Ovary)
 PSS000858|
European Ancestry|
400,812 individuals
 PGP000135 |
Jia G et al. JNCI Cancer Spectr (2020)
 Reported Trait: Incident epithelial ovarian cancer — AUROC: 0.568 [0.537, 0.598] — Genotyping array —
PPM002064 PGS000793
(CC_Ovary_IV)
 PSS001021|
European Ancestry|
211,958 individuals
 PGP000186 |
Kachuri L et al. Nat Commun (2020)
 Reported Trait: Incident ovarian cancer HR: 1.2 [1.1, 1.32] AUROC: 0.66
C-index: 0.654 (0.015)		 R²: 0.193 Age at assessment, family history of breast cancer, genotyping array, PCs(1-15), parity ( ≥1 live birth vs. none), body mass index, Menopausal status (pre-menopausal vs. post-menopausal vs. unknown or hysterectomy), ever used hormone replacement therapy, oral contraceptive use (never used (0) vs. <20 years vs. ≥20 years), BMI*menopausal status C-index calculated as a weighted average between 1 and 5 years and AUC at 5 years.
PPM016269 PGS002250
(PRS_S4)
 PSS010091|
European Ancestry|
198,758 individuals
 PGP000277 |
Dareng EO et al. Eur J Hum Genet (2022)
 Reported Trait: Epithelial non-mucinous ovarian cancer OR: 1.38 [1.28, 1.48] AUROC: 0.588 — — —
PPM016270 PGS002250
(PRS_S4)
 PSS010087|
European Ancestry|
18,915 individuals
 PGP000277 |
Dareng EO et al. Eur J Hum Genet (2022)
 Reported Trait: Epithelial non-mucinous ovarian cancer in BRCA1 carriers HR: 1.36 [1.29, 1.43] AUROC: 0.592 — — —
PPM016271 PGS002250
(PRS_S4)
 PSS010088|
European Ancestry|
12,337 individuals
 PGP000277 |
Dareng EO et al. Eur J Hum Genet (2022)
 Reported Trait: Epithelial non-mucinous ovarian cancer in BRCA2 carriers HR: 1.49 [1.35, 1.64] AUROC: 0.624 — — —
PPM016272 PGS002250
(PRS_S4)
 PSS010090|
East Asian Ancestry|
7,669 individuals
 PGP000277 |
Dareng EO et al. Eur J Hum Genet (2022)
 Reported Trait: Epithelial non-mucinous ovarian cancer OR: 1.14 [1.08, 1.19] AUROC: 0.538 — — —
PPM016273 PGS002250
(PRS_S4)
 PSS010089|
African Ancestry|
1,072 individuals
 PGP000277 |
Dareng EO et al. Eur J Hum Genet (2022)
 Reported Trait: Epithelial non-mucinous ovarian cancer OR: 1.38 [1.21, 1.58] AUROC: 0.593 — — —
PPM016260 PGS003385
(best_OV)
 PSS010083|
European Ancestry|
143,259 individuals
 PGP000413 |
Namba S et al. Cancer Res (2022)
 Reported Trait: ovarian serous carcinoma — AUROC: 0.717 R²: 0.0142 age, top 20 genetic principal components —
PPM016274 PGS003394
(PRS_Stepwise)
 PSS010091|
European Ancestry|
198,758 individuals
 PGP000277 |
Dareng EO et al. Eur J Hum Genet (2022)
 Reported Trait: Epithelial non-mucinous ovarian cancer OR: 1.39 [1.29, 1.5] AUROC: 0.595 — — —
PPM016275 PGS003394
(PRS_Stepwise)
 PSS010090|
East Asian Ancestry|
7,669 individuals
 PGP000277 |
Dareng EO et al. Eur J Hum Genet (2022)
 Reported Trait: Epithelial non-mucinous ovarian cancer OR: 1.17 [1.11, 1.23] AUROC: 0.542 — — —
PPM017029 PGS003394
(PRS_Stepwise)
 PSS010098|
European Ancestry|
189,171 individuals
 PGP000417 |
Dite GS et al. Eur J Cancer Prev (2022)
|Ext.		 Reported Trait: 10-year ovarian cancer risks — C-index: 0.623 [0.603, 0.642] — — —
PPM016276 PGS003394
(PRS_Stepwise)
 PSS010089|
African Ancestry|
1,072 individuals
 PGP000277 |
Dareng EO et al. Eur J Hum Genet (2022)
 Reported Trait: Epithelial non-mucinous ovarian cancer OR: 1.37 [1.2, 1.56] AUROC: 0.594 — — —
PPM018497 PGS003741
(PRS28_OC)
 PSS010991|
European Ancestry|
501 individuals
 PGP000470 |
Xin J et al. EBioMedicine (2023)
 Reported Trait: Ovarian cancer OR: 1.15 [1.04, 1.28] — — — —
PPM018518 PGS003754
(PRS22_OCstepwise)
 PSS011005|
Multi-ancestry (including European)|
11,135 individuals
 PGP000474 |
Hurwitz LM et al. JAMA Netw Open (2023)
 Reported Trait: Nonmucinous Epithelial Ovarian Cancer x aspirin use interaction — — Odds ratio (OR, <median): 0.85 [0.7, 1.02]
Odds ratio (OR, >=median): 0.86 [0.74, 1.01]		 — —
PPM020306 PGS004249
(PRS25_ovary)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Ovarian cancer HR: 1.16 [1.03, 1.31] — — first 10 genetic principal components —
PPM020877 PGS004692
(ovarian_cancer)
 PSS011436|
European Ancestry|
22,025 individuals
 PGP000596 |
Hu J et al. JNCI Cancer Spectr (2024)
 Reported Trait: Ovarian cancer — AUROC: 0.5298 — — —
PPM022170 PGS005086
(PGS64518_OC)
 PSS011825|
East Asian Ancestry|
61,457 individuals
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Reported Trait: Epithelial ovarian cancer OR: 1.12 [1.05, 1.2] — — — —
PPM022166 PGS005086
(PGS64518_OC)
 PSS011826|
European Ancestry|
245,377 individuals
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Reported Trait: Epithelial ovarian cancer OR: 1.46 [1.37, 1.54] AUROC: 0.607 [0.59, 0.623] — — —
PPM022167 PGS005087
(PGS5957_OC)
 PSS011826|
European Ancestry|
245,377 individuals
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Reported Trait: Epithelial ovarian cancer OR: 1.45 AUROC: 0.603 — — —
PPM022171 PGS005087
(PGS5957_OC)
 PSS011825|
East Asian Ancestry|
61,457 individuals
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Reported Trait: Epithelial ovarian cancer OR: 1.14 — — — —
PPM022168 PGS005088
(PGS3448_OC)
 PSS011826|
European Ancestry|
245,377 individuals
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Reported Trait: Epithelial ovarian cancer OR: 1.45 AUROC: 0.604 — — —
PPM022172 PGS005088
(PGS3448_OC)
 PSS011825|
East Asian Ancestry|
61,457 individuals
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Reported Trait: Epithelial ovarian cancer OR: 1.14 — — — —
PPM022169 PGS005089
(PGS400_OC)
 PSS011826|
European Ancestry|
245,377 individuals
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Reported Trait: Epithelial ovarian cancer OR: 1.43 [1.35, 1.52] AUROC: 0.603 — — —
PPM022173 PGS005089
(PGS400_OC)
 PSS011825|
East Asian Ancestry|
61,457 individuals
 PGP000680 |
Barnes DR et al. medRxiv (2024)
|Pre		 Reported Trait: Epithelial ovarian cancer OR: 1.13 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000121 Cancer diagnoses were obtained from reigstry data in GERA, and ICD-9/10 codes mapped to ICD-O-3 codes in UK Biobank. Cancers for this phenotype were classified using the following SEER site recode(s): 27040 —
[
  • 1,261 cases
  • , 219,648 controls
]
,
0.0 % Male samples
 — European — GERA, UKB —
PSS011825 — —
[
  • 843 cases
  • , 60,614 controls
]
,
0.0 % Male samples
 — East Asian
(Japanese)		 — BBJ —
PSS011826 — —
[
  • 848 cases
  • , 244,529 controls
]
,
0.0 % Male samples
 — European
(British)		 — UKB —
PSS011328 — — 133,830 individuals,
0.0 % Male samples
 — European
(British)		 — UKB —
PSS010991 — — 501 individuals Mean = 60.09 years European — TCGA —
PSS011436 — —
[
  • 110 cases
  • , 21,915 controls
]
,
0.0 % Male samples
 — European — UKB —
PSS011005 — —
[
  • 122 cases
  • , 218 controls
]
 — African American or Afro-Caribbean
(Black)		 — OCAC —
PSS011005 — —
[
  • 3,995 cases
  • , 5,851 controls
]
 — European — OCAC —
PSS011005 — —
[
  • 359 cases
  • , 590 controls
]
 — Not reported — OCAC —
PSS000524 — —
[
  • 2,068 cases
  • , 16,867 controls
]
,
0.0 % Male samples
 — European — 59 cohorts
  • BCFR-AU
  • ,BCFR-NY
  • ,BCFR-PA
  • ,BCFR-UTAH
  • ,BFBOCC
  • ,BMBSA
  • ,BRICOH
  • ,CNIO
  • ,COH
  • ,CONSIT_TEAM
  • ,CopBCS
  • ,DEMOKRITOS
  • ,DFCI
  • ,DKFZ
  • ,EMBRACE
  • ,FCCC
  • ,G-FaST
  • ,GC-HBOC
  • ,GEMO
  • ,Georgetown
  • ,HCSC
  • ,HEBCS
  • ,HEBON
  • ,HUNBOCS
  • ,HUVH
  • ,ICO
  • ,IHCC
  • ,INHERIT
  • ,IOVHBOCS
  • ,IPOBCS
  • ,KUMC
  • ,LUHR
  • ,MACBRCA
  • ,MAYO
  • ,MCGILL
  • ,MDACCS
  • ,MODSQUAD
  • ,MSKCC
  • ,MUV
  • ,NC-BCFR
  • ,NCI
  • ,NICCC
  • ,NNPIO
  • ,NRG_ONCOLOGY
  • ,NSUHS
  • ,OCGN
  • ,OFBCR
  • ,OUH
  • ,PiBCS
  • ,SWE-BRCA
  • ,UC
  • ,UCLA
  • ,UCSF
  • ,UKGRFOCR
  • ,UPENN
  • ,UPITT
  • ,VFCTG
  • ,WCRI
  • ,kConFab
 —
PSS000528 — —
[
  • 718 cases
  • , 11,621 controls
]
,
0.0 % Male samples
 — European — 59 cohorts
  • BCFR-AU
  • ,BCFR-NY
  • ,BCFR-PA
  • ,BCFR-UTAH
  • ,BFBOCC
  • ,BMBSA
  • ,BRICOH
  • ,CNIO
  • ,COH
  • ,CONSIT_TEAM
  • ,CopBCS
  • ,DEMOKRITOS
  • ,DFCI
  • ,DKFZ
  • ,EMBRACE
  • ,FCCC
  • ,G-FaST
  • ,GC-HBOC
  • ,GEMO
  • ,Georgetown
  • ,HCSC
  • ,HEBCS
  • ,HEBON
  • ,HUNBOCS
  • ,HUVH
  • ,ICO
  • ,IHCC
  • ,INHERIT
  • ,IOVHBOCS
  • ,IPOBCS
  • ,KUMC
  • ,LUHR
  • ,MACBRCA
  • ,MAYO
  • ,MCGILL
  • ,MDACCS
  • ,MODSQUAD
  • ,MSKCC
  • ,MUV
  • ,NC-BCFR
  • ,NCI
  • ,NICCC
  • ,NNPIO
  • ,NRG_ONCOLOGY
  • ,NSUHS
  • ,OCGN
  • ,OFBCR
  • ,OUH
  • ,PiBCS
  • ,SWE-BRCA
  • ,UC
  • ,UCLA
  • ,UCSF
  • ,UKGRFOCR
  • ,UPENN
  • ,UPITT
  • ,VFCTG
  • ,WCRI
  • ,kConFab
 —
PSS000530 To assess associationss between the PRS and ovarian cancer risk, eligibility was restricted to women who had not been diagnosed with ovarian cancer and had not had RRSO at the time of baselinne questionnaire completion. Carriers diagnosed with invasive ovarian, fallopian tube, or peritoneal cancer during the follow-up were considered affected. —
[
  • 108 cases
  • , 3,044 controls
]
,
0.0 % Male samples
 — European — 61 cohorts
  • BCFR
  • ,BCFR-AU
  • ,BCFR-NY
  • ,BCFR-PA
  • ,BCFR-UTAH
  • ,BFBOCC
  • ,BMBSA
  • ,BRICOH
  • ,CNIO
  • ,COH
  • ,CONSIT_TEAM
  • ,CopBCS
  • ,DEMOKRITOS
  • ,DFCI
  • ,DKFZ
  • ,EMBRACE
  • ,FCCC
  • ,G-FaST
  • ,GC-HBOC
  • ,GEMO
  • ,Georgetown
  • ,HCSC
  • ,HEBCS
  • ,HEBON
  • ,HUNBOCS
  • ,HUVH
  • ,IBCCS
  • ,ICO
  • ,IHCC
  • ,INHERIT
  • ,IOVHBOCS
  • ,IPOBCS
  • ,KUMC
  • ,LUHR
  • ,MACBRCA
  • ,MAYO
  • ,MCGILL
  • ,MDACCS
  • ,MODSQUAD
  • ,MSKCC
  • ,MUV
  • ,NC-BCFR
  • ,NCI
  • ,NICCC
  • ,NNPIO
  • ,NRG_ONCOLOGY
  • ,NSUHS
  • ,OCGN
  • ,OFBCR
  • ,OUH
  • ,PiBCS
  • ,SWE-BRCA
  • ,UC
  • ,UCLA
  • ,UCSF
  • ,UKGRFOCR
  • ,UPENN
  • ,UPITT
  • ,VFCTG
  • ,WCRI
  • ,kConFab
 —
PSS000532 To assess associationss between the PRS and ovarian cancer risk, eligibility was restricted to women who had not been diagnosed with ovarian cancer and had not had RRSO at the time of baseline questionnaire completion. Carriers diagnosed with invasive ovarian, fallopian tbe, or peritoneal cancer during the follow-up were considered affected. —
[
  • 56 cases
  • , 2,439 controls
]
,
0.0 % Male samples
 — European — 61 cohorts
  • BCFR
  • ,BCFR-AU
  • ,BCFR-NY
  • ,BCFR-PA
  • ,BCFR-UTAH
  • ,BFBOCC
  • ,BMBSA
  • ,BRICOH
  • ,CNIO
  • ,COH
  • ,CONSIT_TEAM
  • ,CopBCS
  • ,DEMOKRITOS
  • ,DFCI
  • ,DKFZ
  • ,EMBRACE
  • ,FCCC
  • ,G-FaST
  • ,GC-HBOC
  • ,GEMO
  • ,Georgetown
  • ,HCSC
  • ,HEBCS
  • ,HEBON
  • ,HUNBOCS
  • ,HUVH
  • ,IBCCS
  • ,ICO
  • ,IHCC
  • ,INHERIT
  • ,IOVHBOCS
  • ,IPOBCS
  • ,KUMC
  • ,LUHR
  • ,MACBRCA
  • ,MAYO
  • ,MCGILL
  • ,MDACCS
  • ,MODSQUAD
  • ,MSKCC
  • ,MUV
  • ,NC-BCFR
  • ,NCI
  • ,NICCC
  • ,NNPIO
  • ,NRG_ONCOLOGY
  • ,NSUHS
  • ,OCGN
  • ,OFBCR
  • ,OUH
  • ,PiBCS
  • ,SWE-BRCA
  • ,UC
  • ,UCLA
  • ,UCSF
  • ,UKGRFOCR
  • ,UPENN
  • ,UPITT
  • ,VFCTG
  • ,WCRI
  • ,kConFab
 —
PSS000858 Data and diagnoses on site-specific incident cancers were provided by the National Health Service Information Centre for participants from England and Wales (follow-up through March 31, 2016) and by the NHS Central Register Scotland for participants from Scotland (follow-up through October 31, 2015). Cancers were coded by the International Classification of Diseases, Ninth Revision (ICD-9) or the International Classification of Diseases, Tenth Revision (ICD-10). Ovarian cancer=(ICD-9 = 183.0 or ICD-10 = C56; ICD-O: 8441, 8460, 8462, 8380, 8381, 8470, 8471, 8472, 8473, 8480, 8310, 8140, 8260, 8440, 8450, 9000, 8000, and 8010) Median = 5.8 years
[
  • 358 cases
  • , 400,454 controls
]
,
46.5 % Male samples
 — European — UKB —
PSS010083 C56, histology was one of the followings: Papillary serous cystadenocarcinoma; Serous cystadenocarcinoma; Serous cystadenoma, borderline malignancy; Serous papillary cystic tumor of borderline malignancy; Serous surface papillary carcinoma —
[
  • 367 cases
  • , 142,892 controls
]
 — European
(British)		 — UKB Controls were samples without any cancer diagnosis or self-reported cancer
PSS010149 — —
[
  • 20 cases
  • , 295 controls
]
,
0.0 % Male samples
 — European — UKB —
PSS010087 — —
[
  • 2,053 cases
  • , 16,862 controls
]
,
0.0 % Male samples
 — European — CIMBA —
PSS010088 — —
[
  • 717 cases
  • , 11,620 controls
]
,
0.0 % Male samples
 — European — CIMBA —
PSS010089 — —
[
  • 368 cases
  • , 704 controls
]
,
0.0 % Male samples
 — African unspecified — OCAC —
PSS000278 Primary tumor samples from TCGA —
[
  • 531 cases
  • , 0 controls
]
,
0.0 % Male samples
 Mean = 60.0 years
Sd = 12.0 years		 European — TCGA —
PSS010091 — —
[
  • 657 cases
  • , 198,101 controls
]
,
0.0 % Male samples
 — European — UKB —
PSS000278 — —
[
  • 0 cases
  • , 7,020 controls
]
,
0.0 % Male samples
 — European — eMERGE —
PSS010090 — —
[
  • 2,841 cases
  • , 4,828 controls
]
,
0.0 % Male samples
 — East Asian — OCAC —
PSS000108 Adjudicated endpoint determined from medical notes by an outcome review committee Mean = 11.1 years
IQR = [10.0, 12.0] years
[
  • 750 cases
  • , 1,428 controls
]
,
0.0 % Male samples
 Mean = 63.0 years
Range = [50.0, 74.0] years		 European — UKCTOCS —
PSS000108 Adjudicated endpoint determined from medical notes by an outcome review committee Mean = 11.1 years
IQR = [10.0, 12.0] years
[
  • 489 cases
  • , 1,428 controls
]
,
0.0 % Male samples
 Mean = 63.0 years
Range = [50.0, 74.0] years		 European — UKCTOCS —
PSS010098 — — 189,171 individuals,
0.0 % Male samples
 — European — UKB —
PSS000072 BRCA1 mutation carriers were followed until the age of ovarian cancer diagnosis, age at risk-reducing salpingo-oophorectomy (RRSO) or age at last observation. Breast cancer diagnosis was not considered as a censoring event in the ovarian cancer analysis —
[
  • 2,462 cases
  • , 12,790 controls
]
,
0.0 % Male samples
 — European Some analyses accounted for samples part of the larger cohort with Ashkenazi Jewish ancestry CIMBA Median censoring age (cases) = 50
PSS000073 BRCA2 mutation carriers were followed until the age of ovarian cancer diagnosis, age at risk-reducing salpingo-oophorectomy (RRSO) or age at last observation. Breast cancer diagnosis was not considered as a censoring event in the ovarian cancer analysis —
[
  • 631 cases
  • , 7,580 controls
]
,
0.0 % Male samples
 — European Some analyses accounted for samples part of the larger cohort with Ashkenazi Jewish ancestry CIMBA Median censoring age (cases) = 57
PSS001021 Individuals with at least one recorded incident diagnosis of a borderline, in situ, or malignant primary cancer were defined as cases. —
[
  • 445 cases
  • , 211,513 controls
]
,
0.0 % Male samples
 — European — UKB —