PGS Publication: PGP000443

Publication Information (EuropePMC)
Title Lifestyle, genetic risk and incidence of cancer: a prospective cohort study of 13 cancer types.
PubMed ID 36651198(Europe PMC)
doi 10.1093/ije/dyac238
Publication Date Jan. 18, 2023
Journal Int J Epidemiol
Author(s) Byrne S, Boyle T, Ahmed M, Lee SH, Benyamin B, Hyppönen E.
Released in PGS Catalog: March 3, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS000071
(CC_Bladder)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Bladder cancerurinary bladder carcinoma15
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000071/ScoringFiles/PGS000071.txt.gz
PGS000072
(CC_Breast)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Breast cancerbreast carcinoma187
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000072/ScoringFiles/PGS000072.txt.gz
PGS000074
(CC_Colorectal)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Colorectal cancercolorectal cancer103
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000074/ScoringFiles/PGS000074.txt.gz
PGS000075
(CC_Endo)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Endometrial cancerendometrial carcinoma9
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000075/ScoringFiles/PGS000075.txt.gz
PGS000076
(CC_Kidney)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Kidney cancerrenal cell carcinoma19
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000076/ScoringFiles/PGS000076.txt.gz
PGS000077
(CC_LL)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Lymphocytic leukemialymphoid leukemia75
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000077/ScoringFiles/PGS000077.txt.gz
PGS000078
(CC_Lung)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Lung cancerlung carcinoma109
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000078/ScoringFiles/PGS000078.txt.gz
PGS000079
(CC_Melanoma)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Melanomamelanoma24
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000079/ScoringFiles/PGS000079.txt.gz
PGS000080
(CC_NHL)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Non-Hodgkin's lymphomanon-Hodgkins lymphoma19
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000080/ScoringFiles/PGS000080.txt.gz
PGS000081
(CC_Oral)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Oral cavity and pharyngeal cancersoral cavity cancer,
pharynx cancer		14
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000081/ScoringFiles/PGS000081.txt.gz
PGS000082
(CC_Ovary)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Ovarian cancerovarian carcinoma36
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000082/ScoringFiles/PGS000082.txt.gz
PGS000083
(CC_Pancreas)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Pancreatic cancerpancreatic carcinoma22
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000083/ScoringFiles/PGS000083.txt.gz
PGS000084
(CC_Prostate)
PGP000050 |
Graff RE et al. Nat Commun (2021)
Prostate cancerprostate carcinoma161
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000084/ScoringFiles/PGS000084.txt.gz
Showing 1 to 13 of 13 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM017163PGS000084
(CC_Prostate)
PSS010151|
European Ancestry|
4,476 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Prostate cancerHR: 1.36 [1.32, 1.4]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariatesShow more—
PPM017164PGS000074
(CC_Colorectal)
PSS010144|
European Ancestry|
2,150 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Colorectal cancerHR: 1.36 [1.31, 1.42]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariatesShow more—
PPM017165PGS000072
(CC_Breast)
PSS010142|
European Ancestry|
1,990 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Post-menopausal breast cancerHR: 1.26 [1.2, 1.32]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariatesShow more—
PPM017166PGS000078
(CC_Lung)
PSS010146|
European Ancestry|
1,256 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Lung cancerHR: 1.26 [1.19, 1.33]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariatesShow more—
PPM017167PGS000079
(CC_Melanoma)
PSS010153|
European Ancestry|
1,200 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: MelanomaHR: 1.41 [1.33, 1.49]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariatesShow more—
PPM017168PGS000080
(CC_NHL)
PSS010148|
European Ancestry|
721 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Non-Hodgkin's lymphomaHR: 1.19 [1.11, 1.28]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariatesShow more—
PPM017169PGS000076
(CC_Kidney)
PSS010145|
European Ancestry|
547 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Kidney cancerHR: 1.14 [1.05, 1.24]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariatesShow more—
PPM017170PGS000075
(CC_Endo)
PSS010152|
European Ancestry|
494 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Uterine cancerHR: 1.31 [1.2, 1.44]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariatesShow more—
PPM017171PGS000083
(CC_Pancreas)
PSS010154|
European Ancestry|
451 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Pancreatic cancerHR: 1.51 [1.38, 1.66]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariatesShow more—
PPM017172PGS000071
(CC_Bladder)
PSS010143|
European Ancestry|
424 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Bladder cancerHR: 1.21 [1.1, 1.33]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle indexShow more—
PPM017173PGS000081
(CC_Oral)
PSS010150|
European Ancestry|
415 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Oral cavity and pharyngeal cancersHR: 1.03 [0.94, 1.14]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariatesShow more—
PPM017174PGS000082
(CC_Ovary)
PSS010149|
European Ancestry|
315 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Ovarian cancerHR: 1.09 [0.97, 1.21]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariatesShow more—
PPM017175PGS000077
(CC_LL)
PSS010147|
European Ancestry|
246 individuals
PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		Reported Trait: Lymphocytic leukemiaHR: 1.5 [1.33, 1.69]——age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs... ), Townsend Index, education, birth location, income, lifestyle indexShow more—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS010142——
[
  • 225 cases
  • , 1,765 controls
]
,
0.0 % Male samples
—European—UKB—
PSS010143——
[
  • 31 cases
  • , 393 controls
]
—European—UKB—
PSS010144——
[
  • 180 cases
  • , 1,970 controls
]
—European—UKB—
PSS010145——
[
  • 28 cases
  • , 519 controls
]
—European—UKB—
PSS010146——
[
  • 104 cases
  • , 1,152 controls
]
—European—UKB—
PSS010147——
[
  • 24 cases
  • , 222 controls
]
—European—UKB—
PSS010148——
[
  • 61 cases
  • , 660 controls
]
—European—UKB—
PSS010149——
[
  • 20 cases
  • , 295 controls
]
,
0.0 % Male samples
—European—UKB—
PSS010150——
[
  • 26 cases
  • , 389 controls
]
—European—UKB—
PSS010151——
[
  • 383 cases
  • , 4,093 controls
]
,
100.0 % Male samples
—European—UKB—
PSS010152——
[
  • 35 cases
  • , 459 controls
]
,
0.0 % Male samples
—European—UKB—
PSS010153——
[
  • 121 cases
  • , 1,079 controls
]
—European—UKB—
PSS010154——
[
  • 57 cases
  • , 394 controls
]
—European—UKB—
Showing 1 to 13 of 13 rows