Trait: urinary bladder carcinoma

Trait Information
Identifier MONDO_0004986
Description A carcinoma that arises from epithelial cells of the urinary bladder
Trait category
Cancer
Synonyms 13 synonyms
  • bladder cancer
  • bladder carcinoma
  • cancer of bladder
  • cancer of the bladder
  • cancer of the urinary bladder
  • cancer of urinary bladder
  • carcinoma bladder
  • carcinoma of bladder
  • carcinoma of the bladder
  • carcinoma of the urinary bladder
  • carcinoma of urinary bladder
  • urinary bladder cancer
  • urinary bladder carcinoma
Mapped terms 6 mapped terms
  • DOID:4007
  • HP:0002862
  • MEDGEN:147071
  • NCIT:C4912
  • SCTID:255108000
  • UMLS:C0699885

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000071
(CC_Bladder)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Bladder cancer urinary bladder carcinoma 15
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000071/ScoringFiles/PGS000071.txt.gz
PGS000152
(cGRS_Bladder)
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Bladder cancer urinary bladder carcinoma 10
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000152/ScoringFiles/PGS000152.txt.gz
PGS000607
(PRSWEB_PHECODE189.2_20001-1035_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 1,095,241
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000607/ScoringFiles/PGS000607.txt.gz
PGS000608
(PRSWEB_PHECODE189.2_C3-BLADDER_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 1,097,063
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000608/ScoringFiles/PGS000608.txt.gz
PGS000609
(PRSWEB_PHECODE189.2_C67_LASSOSUM_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 1,130
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000609/ScoringFiles/PGS000609.txt.gz
PGS000610
(PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 13
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000610/ScoringFiles/PGS000610.txt.gz
PGS000611
(PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_UKB_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 13
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000611/ScoringFiles/PGS000611.txt.gz
PGS000612
(PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 13
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000612/ScoringFiles/PGS000612.txt.gz
PGS000613
(PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_UKB_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 15
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000613/ScoringFiles/PGS000613.txt.gz
PGS000614
(PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PRS-CS_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 1,119,238
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000614/ScoringFiles/PGS000614.txt.gz
PGS000615
(PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PT_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 106
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000615/ScoringFiles/PGS000615.txt.gz
PGS000616
(PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_LASSOSUM_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Bladder cancer urinary bladder carcinoma 24,359
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000616/ScoringFiles/PGS000616.txt.gz
PGS000723
(PRS_Bladder)
 PGP000135 |
Jia G et al. JNCI Cancer Spectr (2020)
 Bladder cancer urinary bladder carcinoma 14
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000723/ScoringFiles/PGS000723.txt.gz
PGS000782
(CC_Bladder_IV)
 PGP000186 |
Kachuri L et al. Nat Commun (2020)
 Bladder cancer urinary bladder carcinoma 15
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000782/ScoringFiles/PGS000782.txt.gz
PGS001807
(portability-PLR_189.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Bladder cancer urinary bladder carcinoma 291
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001807/ScoringFiles/PGS001807.txt.gz
PGS002017
(portability-ldpred2_189.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Bladder cancer urinary bladder carcinoma 510,453
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002017/ScoringFiles/PGS002017.txt.gz
PGS003335
(GRS18_BC)
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Bladder cancer urinary bladder carcinoma 18
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003335/ScoringFiles/PGS003335.txt.gz
PGS004241
(PRS12_bladder)
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Bladder cancer urinary bladder carcinoma 12
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004241/ScoringFiles/PGS004241.txt.gz
PGS004687
(bladder_cancer)
 PGP000596 |
Hu J et al. JNCI Cancer Spectr (2024)
 Bladder cancer urinary bladder carcinoma 1,077,775
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004687/ScoringFiles/PGS004687.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000191 PGS000071
(CC_Bladder)
 PSS000110|
European Ancestry|
412,602 individuals
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Reported Trait: Bladder cancer OR: 1.3 [1.25, 1.36] — — Genotyping reagent kit (GERA cohort only), genotyping array (UK Biobank only), age, sex, 10 PCs. Results from meta-analysis of GERA and UKB
PPM002037 PGS000071
(CC_Bladder)
 PSS001010|
European Ancestry|
391,888 individuals
 PGP000186 |
Kachuri L et al. Nat Commun (2020)
|Ext.		 Reported Trait: Incident blader cancer HR: 1.28 [1.2, 1.37] AUROC: 0.803
C-index: 0.813 (0.008)		 — Age at assessment, sex, genotyping array, PCs(1-15), cigarette pack-years, smoking status(never vs. former vs. current), body mass index C-index calculated as a weighted average between 1 and 5 years and AUC at 5 years.
PPM017172 PGS000071
(CC_Bladder)
 PSS010143|
European Ancestry|
424 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Bladder cancer HR: 1.21 [1.1, 1.33] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index —
PPM000472 PGS000152
(cGRS_Bladder)
 PSS000272|
European Ancestry|
13,770 individuals
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Reported Trait: Bladder cancer — — Mean realative risk: 1.04 [1.0, 1.08]
Wilcoxon test (case vs. control) p-value: 0.00377		 — —
PPM000483 PGS000152
(cGRS_Bladder)
 PSS000272|
European Ancestry|
13,770 individuals
 PGP000075 |
Shi Z et al. Cancer Med (2019)
 Reported Trait: Bladder cancer — — Odds Ratio (OR; high vs. average risk groups): 1.58 [1.1, 2.25] — —
PPM001292 PGS000607
(PRSWEB_PHECODE189.2_20001-1035_PRS-CS_MGI_20200608)
 PSS000555|
European Ancestry|
7,622 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of bladder OR: 1.096 [1.018, 1.18]
β: 0.0918 (0.0377)		 AUROC: 0.531 [0.509, 0.551] Nagelkerke's Pseudo-R²: 0.00156
Brier score: 0.0922
Odds Ratio (OR, top 1% vs. Rest): 0.671 [0.279, 1.61]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE189.2_20001-1035_PRS-CS_MGI_20200608
PPM001293 PGS000608
(PRSWEB_PHECODE189.2_C3-BLADDER_PRS-CS_MGI_20200608)
 PSS000555|
European Ancestry|
7,622 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of bladder OR: 1.084 [1.006, 1.167]
β: 0.0803 (0.0377)		 AUROC: 0.521 [0.499, 0.541] Nagelkerke's Pseudo-R²: 0.00124
Brier score: 0.0922
Odds Ratio (OR, top 1% vs. Rest): 1.53 [0.832, 2.83]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE189.2_C3-BLADDER_PRS-CS_MGI_20200608
PPM001294 PGS000609
(PRSWEB_PHECODE189.2_C67_LASSOSUM_MGI_20200608)
 PSS000555|
European Ancestry|
7,622 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of bladder OR: 1.106 [1.027, 1.191]
β: 0.101 (0.0376)		 AUROC: 0.528 [0.508, 0.549] Nagelkerke's Pseudo-R²: 0.00205
Brier score: 0.0922
Odds Ratio (OR, top 1% vs. Rest): 1.69 [0.934, 3.06]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE189.2_C67_LASSOSUM_MGI_20200608
PPM001295 PGS000610
(PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_MGI_20200608)
 PSS000555|
European Ancestry|
7,622 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of bladder OR: 1.292 [1.201, 1.391]
β: 0.256 (0.0375)		 AUROC: 0.572 [0.55, 0.594] Nagelkerke's Pseudo-R²: 0.013
Brier score: 0.0917
Odds Ratio (OR, top 1% vs. Rest): 1.47 [0.779, 2.77]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_MGI_20200608
PPM001296 PGS000611
(PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_UKB_20200608)
 PSS000576|
European Ancestry|
13,530 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of bladder OR: 1.284 [1.211, 1.361]
β: 0.25 (0.0298)		 AUROC: 0.567 [0.551, 0.584] Nagelkerke's Pseudo-R²: 0.0114
Brier score: 0.0821
Odds Ratio (OR, top 1% vs. Rest): 2.66 [1.79, 3.93]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_P_5e-08_UKB_20200608
PPM001297 PGS000612
(PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_MGI_20200608)
 PSS000555|
European Ancestry|
7,622 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of bladder OR: 1.292 [1.201, 1.391]
β: 0.256 (0.0375)		 AUROC: 0.572 [0.55, 0.594] Nagelkerke's Pseudo-R²: 0.013
Brier score: 0.0917
Odds Ratio (OR, top 1% vs. Rest): 1.47 [0.779, 2.77]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_MGI_20200608
PPM001298 PGS000613
(PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_UKB_20200608)
 PSS000576|
European Ancestry|
13,530 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of bladder OR: 1.301 [1.227, 1.379]
β: 0.263 (0.0299)		 AUROC: 0.571 [0.555, 0.588] Nagelkerke's Pseudo-R²: 0.0125
Brier score: 0.0821
Odds Ratio (OR, top 1% vs. Rest): 2.91 [1.99, 4.24]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE189.2_GWAS-Catalog-r2019-05-03-X189.2_PT_UKB_20200608
PPM001299 PGS000614
(PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PRS-CS_MGI_20200608)
 PSS000555|
European Ancestry|
7,622 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of bladder OR: 1.087 [1.01, 1.171]
β: 0.0836 (0.0377)		 AUROC: 0.525 [0.503, 0.547] Nagelkerke's Pseudo-R²: 0.00135
Brier score: 0.0922
Odds Ratio (OR, top 1% vs. Rest): 0.675 [0.28, 1.62]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PRS-CS_MGI_20200608
PPM001300 PGS000615
(PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PT_MGI_20200608)
 PSS000555|
European Ancestry|
7,622 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of bladder OR: 1.084 [1.007, 1.167]
β: 0.0809 (0.0376)		 AUROC: 0.519 [0.498, 0.541] Nagelkerke's Pseudo-R²: 0.00137
Brier score: 0.0922
Odds Ratio (OR, top 1% vs. Rest): 0.788 [0.35, 1.78]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_PT_MGI_20200608
PPM001301 PGS000616
(PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_LASSOSUM_MGI_20200608)
 PSS000555|
European Ancestry|
7,622 individuals
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Reported Trait: Cancer of bladder OR: 1.138 [1.057, 1.225]
β: 0.129 (0.0376)		 AUROC: 0.538 [0.517, 0.557] Nagelkerke's Pseudo-R²: 0.00345
Brier score: 0.0921
Odds Ratio (OR, top 1% vs. Rest): 0.983 [0.459, 2.11]		 age, sex, batch PCs 1-4 Cancer PRSweb PheWAS Results: PRSWEB_PHECODE189.2_UKBB-SAIGE-HRC-X189.2_LASSOSUM_MGI_20200608
PPM001653 PGS000723
(PRS_Bladder)
 PSS000853|
European Ancestry|
400,812 individuals
 PGP000135 |
Jia G et al. JNCI Cancer Spectr (2020)
 Reported Trait: Incident bladder cancer — AUROC: 0.583 [0.559, 0.607] — Genotyping array —
PPM002053 PGS000782
(CC_Bladder_IV)
 PSS001010|
European Ancestry|
391,888 individuals
 PGP000186 |
Kachuri L et al. Nat Commun (2020)
 Reported Trait: Incident blader cancer HR: 1.3 [1.22, 1.39] AUROC: 0.804
C-index: 0.814 (0.008)		 R²: 0.628 Age at assessment, sex, genotyping array, PCs(1-15), cigarette pack-years, smoking status(never vs. former vs. current), body mass index C-index calculated as a weighted average between 1 and 5 years and AUC at 5 years.
PPM009359 PGS001807
(portability-PLR_189.2)
 PSS009277|
European Ancestry|
19,893 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0197 [0.0058, 0.0336] sex, age, birth date, deprivation index, 16 PCs —
PPM009360 PGS001807
(portability-PLR_189.2)
 PSS009051|
European Ancestry|
4,121 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0266 [-0.004, 0.0572] sex, age, birth date, deprivation index, 16 PCs —
PPM009361 PGS001807
(portability-PLR_189.2)
 PSS008605|
European Ancestry|
6,645 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0169 [-0.0072, 0.041] sex, age, birth date, deprivation index, 16 PCs —
PPM009362 PGS001807
(portability-PLR_189.2)
 PSS008382|
Greater Middle Eastern Ancestry|
1,195 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0347 [-0.0225, 0.0917] sex, age, birth date, deprivation index, 16 PCs —
PPM009363 PGS001807
(portability-PLR_189.2)
 PSS008159|
South Asian Ancestry|
6,301 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): -0.0016 [-0.0263, 0.0231] sex, age, birth date, deprivation index, 16 PCs —
PPM009365 PGS001807
(portability-PLR_189.2)
 PSS007728|
African Ancestry|
2,471 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): -0.0043 [-0.0439, 0.0353] sex, age, birth date, deprivation index, 16 PCs —
PPM009366 PGS001807
(portability-PLR_189.2)
 PSS008831|
African Ancestry|
3,914 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0359 [0.0045, 0.0673] sex, age, birth date, deprivation index, 16 PCs —
PPM009364 PGS001807
(portability-PLR_189.2)
 PSS007946|
East Asian Ancestry|
1,803 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0321 [-0.0144, 0.0784] sex, age, birth date, deprivation index, 16 PCs —
PPM011010 PGS002017
(portability-ldpred2_189.2)
 PSS009277|
European Ancestry|
19,893 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0181 [0.0042, 0.032] sex, age, birth date, deprivation index, 16 PCs —
PPM011011 PGS002017
(portability-ldpred2_189.2)
 PSS009051|
European Ancestry|
4,121 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0333 [0.0026, 0.0638] sex, age, birth date, deprivation index, 16 PCs —
PPM011012 PGS002017
(portability-ldpred2_189.2)
 PSS008605|
European Ancestry|
6,645 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0144 [-0.0097, 0.0385] sex, age, birth date, deprivation index, 16 PCs —
PPM011013 PGS002017
(portability-ldpred2_189.2)
 PSS008382|
Greater Middle Eastern Ancestry|
1,195 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0296 [-0.0276, 0.0867] sex, age, birth date, deprivation index, 16 PCs —
PPM011014 PGS002017
(portability-ldpred2_189.2)
 PSS008159|
South Asian Ancestry|
6,301 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0047 [-0.02, 0.0294] sex, age, birth date, deprivation index, 16 PCs —
PPM011015 PGS002017
(portability-ldpred2_189.2)
 PSS007946|
East Asian Ancestry|
1,803 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0257 [-0.0208, 0.072] sex, age, birth date, deprivation index, 16 PCs —
PPM011017 PGS002017
(portability-ldpred2_189.2)
 PSS008831|
African Ancestry|
3,914 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): 0.0257 [-0.0057, 0.0571] sex, age, birth date, deprivation index, 16 PCs —
PPM011016 PGS002017
(portability-ldpred2_189.2)
 PSS007728|
African Ancestry|
2,471 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Cancer of bladder — — Partial Correlation (partial-r): -0.0071 [-0.0467, 0.0325] sex, age, birth date, deprivation index, 16 PCs —
PPM016166 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Urothelial carcinoma HR: 1.27 [1.15, 1.4] — — Smoking, BMI, education, and physical activity —
PPM016167 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Non-aggressive urothelial carcinoma HR: 1.34 [1.18, 1.52] — — Smoking, BMI, education, and physical activity —
PPM016168 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Aggressive urothelial carcinoma HR: 1.19 [1.0, 1.42] — — Smoking, BMI, education, and physical activity —
PPM016169 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Urothelial carcinoma x systolic blood pressure interaction HR: 1.55 [1.14, 2.1] — — Smoking, BMI, physical activity and level of education —
PPM016170 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Non-aggressive urothelial carcinoma x systolic blood pressure interaction HR: 1.59 [1.07, 2.35] — — Smoking, BMI, physical activity and level of education —
PPM016171 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Aggressive urothelial carcinoma x systolic blood pressure interaction HR: 1.72 [1.03, 2.87] — — Smoking, BMI, physical activity and level of education —
PPM016172 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Urothelial carcinoma x diastolic blood pressure interaction HR: 1.45 [1.09, 1.92] — — Smoking, BMI, physical activity and level of education —
PPM016173 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Non-aggressive urothelial carcinoma x diastolic blood pressure interaction HR: 1.54 [1.07, 2.22] — — Smoking, BMI, physical activity and level of education —
PPM016174 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Aggressive urothelial carcinoma x diastolic blood pressure interaction HR: 1.38 [0.82, 2.31] — — Smoking, BMI, physical activity and level of education —
PPM020298 PGS004241
(PRS12_bladder)
 PSS011328|
European Ancestry|
133,830 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Bladder cancer HR: 1.41 [1.09, 1.83] — — first 10 genetic principal components —
PPM020308 PGS004241
(PRS12_bladder)
 PSS011329|
European Ancestry|
115,207 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Bladder cancer HR: 1.28 [1.12, 1.48] — — first 10 genetic principal components —
PPM020872 PGS004687
(bladder_cancer)
 PSS011431|
European Ancestry|
40,771 individuals
 PGP000596 |
Hu J et al. JNCI Cancer Spectr (2024)
 Reported Trait: Bladder cancer — AUROC: 0.5582 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000555 PheCode:189.2; ICD9CM:188.0, 188.1, 188.2, 188.3, 188.4, 188.5, 188.6, 188.7, 188.8, 188.9, 233.7, 236.7, 239.4, V10.51; ICD10CM:C67, C67.0, C67.1, C67.2, C67.3, C67.4, C67.5, C67.6, C67.7, C67.8, C67.9, D09.0, D41.4, D49.4 —
[
  • 789 cases
  • , 6,833 controls
]
 — European — MGI —
PSS010054 — —
[
  • 385 cases
  • , 10,191 controls
]
,
100.0 % Male samples
 Mean = 59.0 years European — MDC —
PSS011328 — — 133,830 individuals,
0.0 % Male samples
 — European
(British)		 — UKB —
PSS011329 — — 115,207 individuals,
100.0 % Male samples
 — European
(British)		 — UKB —
PSS011431 — —
[
  • 257 cases
  • , 40,514 controls
]
 — European — UKB —
PSS000576 PheCode:189.2; ICD9:233.7, 236.7, 239.4; ICD10:C67.0, C67.1, C67.2, C67.3, C67.4, C67.5, C67.6, C67.7, C67.8, C67.9, D09.0, D41.4 —
[
  • 1,229 cases
  • , 12,301 controls
]
 — European — UKB —
PSS009051 — — 4,121 individuals — European Poland (NE Europe) UKB —
PSS008159 — — 6,301 individuals — South Asian India (South Asia) UKB —
PSS008831 — — 3,914 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007946 — — 1,803 individuals — East Asian China (East Asia) UKB —
PSS000853 Data and diagnoses on site-specific incident cancers were provided by the National Health Service Information Centre for participants from England and Wales (follow-up through March 31, 2016) and by the NHS Central Register Scotland for participants from Scotland (follow-up through October 31, 2015). Cancers were coded by the International Classification of Diseases, Ninth Revision (ICD-9) or the International Classification of Diseases, Tenth Revision (ICD-10). Bladder cancer =(ICD-9 = 188 or ICD-10 = C67). Median = 5.8 years
[
  • 513 cases
  • , 400,299 controls
]
,
46.5 % Male samples
 — European — UKB —
PSS000272 Primary tumor samples from TCGA —
[
  • 343 cases
  • , 0 controls
]
 Mean = 69.0 years
Sd = 10.0 years		 European — TCGA —
PSS000272 — —
[
  • 0 cases
  • , 13,427 controls
]
 — European — eMERGE —
PSS010143 — —
[
  • 31 cases
  • , 393 controls
]
 — European — UKB —
PSS008605 — — 6,645 individuals — European Italy (South Europe) UKB —
PSS007728 — — 2,471 individuals — African American or Afro-Caribbean Carribean UKB —
PSS001010 Individuals with at least one recorded incident diagnosis of a borderline, in situ, or malignant primary cancer were defined as cases. —
[
  • 890 cases
  • , 390,998 controls
]
 — European — UKB —
PSS000110 Cancer diagnoses were obtained from reigstry data in GERA, and ICD-9/10 codes mapped to ICD-O-3 codes in UK Biobank. Cancers for this phenotype were classified using the following SEER site recode(s): 29010 —
[
  • 2,248 cases
  • , 410,354 controls
]
,
46.0 % Male samples
 Mean = 58.0 years European — GERA, UKB —
PSS009277 — — 19,893 individuals — European UK (+ Ireland) UKB —
PSS008382 — — 1,195 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —