PGS Publication: PGP000404

Publication Information (EuropePMC)
Title Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men.
PubMed ID 36316463(Europe PMC)
doi 10.1038/s41598-022-23225-6
Publication Date Oct. 31, 2022
Journal Sci Rep
Author(s) Teleka S, Orho-Melander M, Liedberg F, Melander O, Jirström K, Stocks T.
Released in PGS Catalog: Dec. 20, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003335
(GRS18_BC)
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Bladder cancer urinary bladder carcinoma 18
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003335/ScoringFiles/PGS003335.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016166 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Urothelial carcinoma HR: 1.27 [1.15, 1.4] — — Smoking, BMI, education, and physical activity —
PPM016167 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Non-aggressive urothelial carcinoma HR: 1.34 [1.18, 1.52] — — Smoking, BMI, education, and physical activity —
PPM016168 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Aggressive urothelial carcinoma HR: 1.19 [1.0, 1.42] — — Smoking, BMI, education, and physical activity —
PPM016169 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Urothelial carcinoma x systolic blood pressure interaction HR: 1.55 [1.14, 2.1] — — Smoking, BMI, physical activity and level of education —
PPM016170 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Non-aggressive urothelial carcinoma x systolic blood pressure interaction HR: 1.59 [1.07, 2.35] — — Smoking, BMI, physical activity and level of education —
PPM016171 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Aggressive urothelial carcinoma x systolic blood pressure interaction HR: 1.72 [1.03, 2.87] — — Smoking, BMI, physical activity and level of education —
PPM016172 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Urothelial carcinoma x diastolic blood pressure interaction HR: 1.45 [1.09, 1.92] — — Smoking, BMI, physical activity and level of education —
PPM016173 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Non-aggressive urothelial carcinoma x diastolic blood pressure interaction HR: 1.54 [1.07, 2.22] — — Smoking, BMI, physical activity and level of education —
PPM016174 PGS003335
(GRS18_BC)
 PSS010054|
European Ancestry|
10,576 individuals
 PGP000404 |
Teleka S et al. Sci Rep (2022)
 Reported Trait: Aggressive urothelial carcinoma x diastolic blood pressure interaction HR: 1.38 [0.82, 2.31] — — Smoking, BMI, physical activity and level of education —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010054 — —
[
  • 385 cases
  • , 10,191 controls
]
,
100.0 % Male samples
 Mean = 59.0 years European — MDC —