Predicted Trait | |
Reported Trait | Ovarian cancer |
Mapped Trait(s) | ovarian carcinoma (EFO_0001075) |
Score Construction | |
PGS Name | PRS-OC |
Development Method | |
Name | PRS-CSx |
Parameters | MAF≥0.01, INFO≥0.3, and P<0.05 |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 2,802 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000711 |
Citation (link to publication) | Zhu M et al. PLoS Med (2025) |
Ancestry Distribution | |
Source of Variant Associations (GWAS) | European: 58.2% East Asian: 41.8% 146,883 individuals (100%) |
PGS Evaluation | East Asian: 100% 1 Sample Sets |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
GWAS Catalog: GCST90018668 Europe PMC: 34594039 |
61,457 individuals | East Asian | BBJ |
GWAS Catalog: GCST004462 Europe PMC: 28346442 |
85,426 individuals | European | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM022404 | PSS011944| East Asian Ancestry| 57,359 individuals |
PGP000711 | Zhu M et al. PLoS Med (2025) |
Reported Trait: Ovarian Cancer | HR: 1.25 [1.02, 1.52] β: 0.223 |
C-index: 0.579 | — | Age,Sex (if applicable),Region,Top 10 genetic ancestry principal components | The HR and C-index values were derived from Cox proportional hazards regression models. |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011944 | ICD-10: C56 | Median = 11.33 years Range = [10.18, 12.26] years |
[ ,
0.0 % Male samples |
Mean = 53.69 years Sd = 11.01 years |
East Asian (Chinese) |
— | CKB | — |