| Predicted Trait | |
| Reported Trait | Body mass index |
| Mapped Trait(s) | body mass index (EFO_0004340) |
| Score Construction | |
| PGS Name | GRS103_BMI |
| Development Method | |
| Name | Genome-wide significant SNPs |
| Parameters | information quality >0.8, MAF >1%, p < .05/103 or .0005 |
| Variants | |
| Original Genome Build | NR |
| Number of Variants | 103 |
| Effect Weight Type | Unweighted |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000549 |
| Citation (link to publication) | Fernández-Rhodes L et al. Psychosom Med (2023) |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
|---|---|---|---|
GWAS Catalog: GCST000830 Europe PMC: 20935630 | 123,865 individuals | European | NR |
GWAS Catalog: GCST001955 Europe PMC: 23563607 | 16,068 individuals | European | NR |
GWAS Catalog: GCST001967 Europe PMC: 23583978 | 37,956 individuals | African American or Afro-Caribbean | NR |
GWAS Catalog: GCST001967 Europe PMC: 23583978 | 1,188 individuals | Sub-Saharan African | NR |
GWAS Catalog: GCST002783 Europe PMC: 25673413 | 236,781 individuals | European | NR |
GWAS Catalog: GCST002783 Europe PMC: 25673413 | 887 individuals | African American or Afro-Caribbean | NR |
GWAS Catalog: GCST002783 Europe PMC: 25673413 | 1,276 individuals | Hispanic or Latin American | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM020403 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index | — | — | Beta (per effect allele): 0.34 | — | — |
| PPM020404 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index in females | — | — | Beta (per effect allele): 0.37 | — | — |
| PPM020405 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index in males | — | — | Beta (per effect allele): 0.27 | — | — |
| PPM020406 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index x SASH language use subscale interaction | — | — | Beta (per effect allele): 0.17 (0.02) | age, sex, top 5 principal components, and study site | — |
| PPM020407 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index x SASH language use subscale interaction in females | — | — | Beta (per effect allele): 0.15 (0.03) | age, sex, top 5 principal components, and study site | — |
| PPM020408 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index x SASH language use subscale interaction in males | — | — | Beta (per effect allele): 0.22 (0.03) | age, sex, top 5 principal components, and study site | — |
| PPM020409 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index x nativity interaction | — | — | Beta (per effect allele): 0.19 (0.03) | age, sex, top 5 principal components, and study site | — |
| PPM020410 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index x nativity interaction in females | — | — | Beta (per effect allele): 0.23 (0.04) | age, sex, top 5 principal components, and study site | — |
| PPM020411 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index x nativity interaction in males | — | — | Beta (per effect allele): 0.15 (0.03) | age, sex, top 5 principal components, and study site | — |
| PPM020412 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index x time in United States interaction | — | — | Beta (per effect allele): 0.09 (0.01) | age, sex, top 5 principal components, and study site | — |
| PPM020413 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index x time in United States interaction in females | — | — | Beta (per effect allele): 0.11 (0.01) | age, sex, top 5 principal components, and study site | — |
| PPM020414 | PSS011351| Hispanic or Latin American Ancestry| 11,747 individuals | PGP000549 | Fernández-Rhodes L et al. Psychosom Med (2023) | Reported Trait: Body mass index x time in United States interaction in males | — | — | Beta (per effect allele): 0.06 (0.01) | age, sex, top 5 principal components, and study site | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS011351 | — | — | 11,747 individuals, 49.1 % Male samples | Mean = 43.0 years | Hispanic or Latin American | — | HCHS, SOL | — |