Polygenic Score (PGS) ID: PGS004326

Predicted Trait
Reported Trait Rheumatoid arthritis
Mapped Trait(s) rheumatoid arthritis (EFO_0000685)
Released in PGS Catalog: Jan. 11, 2024
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS154_RA
Development Method
Name Genome-wide significant SNPs
Parameters p<5E-08, r2 < 0.01
Variants
Original Genome Build NR
Number of Variants 154
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000560
Citation (link to publication) Zhang J et al. Environ Health Perspect (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 72.1%
East Asian: 27.9%
80,799 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST002318
Europe PMC: 24390342
58,284 individualsEuropeanNR
GWAS Catalog: GCST002318
Europe PMC: 24390342
22,515 individualsEast AsianNR
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM020440PSS011363|
European Ancestry|
342,973 individuals
PGP000560 |
Zhang J et al. Environ Health Perspect (2023)
Reported Trait: Incident rheumatoid arthritisHR: 1.22 [1.17, 1.27]——age, sex, UK Biobank assessment center, household income, education level, smoking status, body mass...  index, alcohol consumption, sedentary time, physical activity duration, healthy diet score, first 10 genetic principal components, and genotyping batch.Show more—
PPM020441PSS011363|
European Ancestry|
342,973 individuals
PGP000560 |
Zhang J et al. Environ Health Perspect (2023)
Reported Trait: Incident rheumatoid arthritis with air pollution——Hazard ratio (HR, high air pollution and PRS in top tertile vs low air pollution and PRS in bottom tertile): 1.73 [1.39, 2.17]age, sex, UK Biobank assessment center, household income, education level, smoking status, body mass...  index, alcohol consumption, sedentary time, physical activity duration, healthy diet score, first 10 genetic principal components, and genotyping batch.Show more—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011363ICD10: M05, M06Median = 8.1 years
[
  • 2,034 cases
  • , 340,939 controls
]
,
46.58 % Male samples
Mean = 57.0 years
Sd = 7.9 years		European—UKB—
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