PGS Publication: PGP000560

Publication Information (EuropePMC)
Title Association of Combined Exposure to Ambient Air Pollutants, Genetic Risk, and Incident Rheumatoid Arthritis: A Prospective Cohort Study in the UK Biobank.
PubMed ID 36913237(Europe PMC)
doi 10.1289/ehp10710
Publication Date March 13, 2023
Journal Environ Health Perspect
Author(s) Zhang J, Fang XY, Wu J, Fan YG, Leng RX, Liu B, Lv XJ, Yan YL, Mao C, Ye DQ.
Released in PGS Catalog: Jan. 11, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004326
(PRS154_RA)
 PGP000560 |
Zhang J et al. Environ Health Perspect (2023)
 Rheumatoid arthritis rheumatoid arthritis 154
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004326/ScoringFiles/PGS004326.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020440 PGS004326
(PRS154_RA)
 PSS011363|
European Ancestry|
342,973 individuals
 PGP000560 |
Zhang J et al. Environ Health Perspect (2023)
 Reported Trait: Incident rheumatoid arthritis HR: 1.22 [1.17, 1.27] — — age, sex, UK Biobank assessment center, household income, education level, smoking status, body mass index, alcohol consumption, sedentary time, physical activity duration, healthy diet score, first 10 genetic principal components, and genotyping batch. —
PPM020441 PGS004326
(PRS154_RA)
 PSS011363|
European Ancestry|
342,973 individuals
 PGP000560 |
Zhang J et al. Environ Health Perspect (2023)
 Reported Trait: Incident rheumatoid arthritis with air pollution — — Hazard ratio (HR, high air pollution and PRS in top tertile vs low air pollution and PRS in bottom tertile): 1.73 [1.39, 2.17] age, sex, UK Biobank assessment center, household income, education level, smoking status, body mass index, alcohol consumption, sedentary time, physical activity duration, healthy diet score, first 10 genetic principal components, and genotyping batch. —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011363 ICD10: M05, M06 Median = 8.1 years
[
  • 2,034 cases
  • , 340,939 controls
]
,
46.58 % Male samples
 Mean = 57.0 years
Sd = 7.9 years		 European — UKB —