Polygenic Score (PGS) ID: PGS004599

Predicted Trait
Reported Trait Prostate cancer
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Released in PGS Catalog: Jan. 26, 2024
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Score Details

Score Construction
PGS Name PRS102_Pca
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 102
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000577
Citation (link to publication) Ruan X et al. J Clin Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
57,978 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST011046
Europe PMC: 33398198
 27,420 individuals East Asian NR
GWAS Catalog: GCST008860
Europe PMC: 31562322
 15,770 individuals East Asian NR
GWAS Catalog: GCST000750
Europe PMC: 20676098
 4,969 individuals East Asian NR
GWAS Catalog: GCST001702
Europe PMC: 23023329
 2,425 individuals East Asian NR
GWAS Catalog: GCST003148
Europe PMC: 26443449
 7,394 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020753 PSS011391|
East Asian Ancestry|
3,166 individuals
 PGP000577 |
Ruan X et al. J Clin Med (2023)
 Reported Trait: Prostate cancer — — Odds ratio (OR, high vs low PRS quintile): 3.63 [2.61, 5.0] Age, family history, PSA, %fPSA, 10 PCs —
PPM020754 PSS011391|
East Asian Ancestry|
3,166 individuals
 PGP000577 |
Ruan X et al. J Clin Med (2023)
 Reported Trait: Prostate cancer — AUROC: 0.904 [0.887, 0.921] — Age, familiy history, log(prostate volume), log(prostate health index) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011391 — —
[
  • 1,396 cases
  • , 1,770 controls
]
,
100.0 % Male samples
 Median = 68.0 years
IQR = [62.0, 74.0] years		 East Asian
(Chinese)		 — NR —