PGS Publication: PGP000577

Publication Information (EuropePMC)
Title The Combined Effect of Polygenic Risk Score and Prostate Health Index in Chinese Men Undergoing Prostate Biopsy.
PubMed ID 36835879(Europe PMC)
doi 10.3390/jcm12041343
Publication Date Feb. 8, 2023
Journal J Clin Med
Author(s) Ruan X, Huang D, Huang J, Huang J, Zhan Y, Wu Y, Ding Q, Xu D, Jiang H, Xue W, Na R.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004599
(PRS102_Pca)
 PGP000577 |
Ruan X et al. J Clin Med (2023)
 Prostate cancer prostate carcinoma 102
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004599/ScoringFiles/PGS004599.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020753 PGS004599
(PRS102_Pca)
 PSS011391|
East Asian Ancestry|
3,166 individuals
 PGP000577 |
Ruan X et al. J Clin Med (2023)
 Reported Trait: Prostate cancer — — Odds ratio (OR, high vs low PRS quintile): 3.63 [2.61, 5.0] Age, family history, PSA, %fPSA, 10 PCs —
PPM020754 PGS004599
(PRS102_Pca)
 PSS011391|
East Asian Ancestry|
3,166 individuals
 PGP000577 |
Ruan X et al. J Clin Med (2023)
 Reported Trait: Prostate cancer — AUROC: 0.904 [0.887, 0.921] — Age, familiy history, log(prostate volume), log(prostate health index) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011391 — —
[
  • 1,396 cases
  • , 1,770 controls
]
,
100.0 % Male samples
 Median = 68.0 years
IQR = [62.0, 74.0] years		 East Asian
(Chinese)		 — NR —