Polygenic Score (PGS) ID: PGS004610

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: Feb. 20, 2024
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name child_BMI
Development Method
Name Genome-wide significant SNPs
Parameters r2 ≤ 0.001, distance ≥ 250 kb, 0.01 ≤ MAF ≤ 0.99
Variants
Original Genome Build GRCh37
Number of Variants 306
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000585
Citation (link to publication) Hawkes G et al. Diabetologia (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
441,761 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
—441,761 individualsEuropeanUKB
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM020773PSS011402|
European Ancestry|
4,704 individuals
PGP000585 |
Hawkes G et al. Diabetologia (2023)
Reported Trait: Childhood body mass index (at age 11 years)OR: 1.32 [1.21, 1.44]———Odds ratio for having a BMI greater than 1 standard deviation from the mean
PPM020774PSS011401|
European Ancestry|
5,774 individuals
PGP000585 |
Hawkes G et al. Diabetologia (2023)
Reported Trait: Adulthood body mass index (at age 44 years)OR: 1.16 [1.08, 1.25]———Odds ratio for having a BMI greater than 1 standard deviation from the mean
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011401——5,774 individuals—European—NCDS—
PSS011402——4,704 individuals—European—NCDS—
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