PGS Publication: PGP000585

Publication Information (EuropePMC)
Title Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.
PubMed ID 37280435(Europe PMC)
doi 10.1007/s00125-023-05923-6
Publication Date June 6, 2023
Journal Diabetologia
Author(s) Hawkes G, Beaumont RN, Tyrrell J, Power GM, Wood A, Laakso M, Fernandes Silva L, Boehnke M, Yin X, Richardson TG, Smith GD, Frayling TM.
Released in PGS Catalog: Feb. 20, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004610
(child_BMI)
 PGP000585 |
Hawkes G et al. Diabetologia (2023)
 Body mass index (BMI) body mass index 306
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004610/ScoringFiles/PGS004610.txt.gz
PGS004609
(adult_BMI)
 PGP000585 |
Hawkes G et al. Diabetologia (2023)
 Body mass index (BMI) body mass index 1,127
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004609/ScoringFiles/PGS004609.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020771 PGS004609
(adult_BMI)
 PSS011401|
European Ancestry|
5,774 individuals
 PGP000585 |
Hawkes G et al. Diabetologia (2023)
 Reported Trait: Adulthood body mass index (at age 44 years) OR: 1.55 [1.43, 1.67] — — — Odds ratio for having a BMI greater than 1 standard deviation from the mean
PPM020772 PGS004609
(adult_BMI)
 PSS011402|
European Ancestry|
4,704 individuals
 PGP000585 |
Hawkes G et al. Diabetologia (2023)
 Reported Trait: Childhood body mass index (at age 11 years) OR: 1.32 [1.2, 1.44] — — — Odds ratio for having a BMI greater than 1 standard deviation from the mean
PPM020773 PGS004610
(child_BMI)
 PSS011402|
European Ancestry|
4,704 individuals
 PGP000585 |
Hawkes G et al. Diabetologia (2023)
 Reported Trait: Childhood body mass index (at age 11 years) OR: 1.32 [1.21, 1.44] — — — Odds ratio for having a BMI greater than 1 standard deviation from the mean
PPM020774 PGS004610
(child_BMI)
 PSS011401|
European Ancestry|
5,774 individuals
 PGP000585 |
Hawkes G et al. Diabetologia (2023)
 Reported Trait: Adulthood body mass index (at age 44 years) OR: 1.16 [1.08, 1.25] — — — Odds ratio for having a BMI greater than 1 standard deviation from the mean

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011402 — — 4,704 individuals — European — NCDS —
PSS011401 — — 5,774 individuals — European — NCDS —