Polygenic Score (PGS) ID: PGS004902

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: July 31, 2024
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Score Details

Score Construction
PGS Name PRSBMI
Development Method
Name PRSice
Parameters LD r2=0.8, clumpind distance=250kb; p value threshold = 0.024
Variants
Original Genome Build hg19
Number of Variants 322,639
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000631
Citation (link to publication) Chikowore T et al. Genome Med (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 71.4%
African: 14.1%
Hispanic or Latin American: 9.9%
Multi-ancestry (excluding European): 2.1%
  • East Asian
  • Additional Asian Ancestries
Additional Diverse Ancestries: 2.1%
Not Reported: 0.5%
221,745 individuals (100%)
PGS Evaluation
African: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST009057
Europe PMC: 31675503
 14,126 individuals Sub-Saharan African NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 21,955 individuals Hispanic or Latin American NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 17,127 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 4,647 individuals East Asian, Asian unspecified NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 3,936 individuals Oceanian NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 645 individuals Native American NR
GWAS Catalog: GCST008025
Europe PMC: 31217584
 1,025 individuals Not reported NR
GWAS Catalog: GCST004904
Europe PMC: 28892062
 158,284 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021332 PSS011688|
African Ancestry|
10,180 individuals
 PGP000631 |
Chikowore T et al. Genome Med (2024)
 Reported Trait: Body Mass index — — R²: 0.3008
Incremental R2: 0.92		 age, sex, 5PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011688 — — 10,180 individuals,
45.0 % Male samples
 Mean = 51.8 years African unspecified
(Continental Africans)		 — AWI-Gen —