PGS Publication: PGP000631

Publication Information (EuropePMC)
Title Variability of polygenic prediction for body mass index in Africa.
PubMed ID 38816834(Europe PMC)
doi 10.1186/s13073-024-01348-x
Publication Date May 30, 2024
Journal Genome Med
Author(s) Chikowore T, Läll K, Micklesfield LK, Lombard Z, Goedecke JH, Fatumo S, Norris SA, Magi R, Ramsay M, Franks PW, Pare G, Morris AP.
Released in PGS Catalog: July 31, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004902
(PRSBMI)
 PGP000631 |
Chikowore T et al. Genome Med (2024)
 Body mass index (BMI) body mass index 322,639
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004902/ScoringFiles/PGS004902.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021332 PGS004902
(PRSBMI)
 PSS011688|
African Ancestry|
10,180 individuals
 PGP000631 |
Chikowore T et al. Genome Med (2024)
 Reported Trait: Body Mass index — — R²: 0.3008
Incremental R2: 0.92		 age, sex, 5PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011688 — — 10,180 individuals,
45.0 % Male samples
 Mean = 51.8 years African unspecified
(Continental Africans)		 — AWI-Gen —