Polygenic Score (PGS) ID: PGS004919

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: June 12, 2024
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name CAD_GRS_50
Development Method
Name Genome-wide significant variants
Parameters NR
Variants
Original Genome Build NR
Number of Variants 50
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000650
Citation (link to publication) Sjögren M et al. Int J Cardiol Heart Vasc (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 86.3%
South Asian: 13.7%
170,575 individuals (100%)
PGS Evaluation
Not Reported: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Europe PMC: 21966275
[
  • 11,202 cases
  • , 30,733 controls
]
European9 cohorts
  • ARIC
  • ,BHF-FHS
  • ,BLOODOMICS
  • ,CARDIA
  • ,CHS
  • ,FOS
  • ,KORA
  • ,PROCARDIS
  • ,PennCATH
Europe PMC: 21966275
[
  • 4,394 cases
  • , 4,259 controls
]
South AsianLOLIPOP, PROMIS
GWAS Catalog: GCST000338
Europe PMC: 19198612
2,520 individualsEuropeanGerMIFS
GWAS Catalog: GCST000998
Europe PMC: 21378990
86,995 individualsEuropean15 cohorts
  • ADVANCE
  • ,AtheroRemo 1
  • ,AtheroRemo 2
  • ,B58C
  • ,CADomics
  • ,CHARGE
  • ,GerMIFS
  • ,KORA
  • ,LURIC
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PennCATH
  • ,WTCCC
  • ,deCODE_CAD
GWAS Catalog: GCST000999
Europe PMC: 21378988
15,682 individualsEuropeanHPS, LOLIPOP, PROCARDIS, PROMIS
GWAS Catalog: GCST000999
Europe PMC: 21378988
14,790 individualsSouth Asian
(India, Pakistan)		HPS, LOLIPOP, PROCARDIS, PROMIS
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM021385PSS011720|
Ancestry Not Reported|
23,594 individuals
PGP000650 |
Sjögren M et al. Int J Cardiol Heart Vasc (2019)
Reported Trait: Number of hospitilizations for any cause——Incidence Rate Ratio (IRR, top vs bottom PGS quintiles): 1.1 [1.04, 1.16]Age, sex, follow up time, hypertension, prevalent diabetes, smoking, ApoA1, ApoB—
PPM021386PSS011721|
Ancestry Not Reported|
23,594 individuals
PGP000650 |
Sjögren M et al. Int J Cardiol Heart Vasc (2019)
Reported Trait: Number of cardiovascular-related hospitalizations——Incidence Rate Ratio (IRR, top vs bottom PGS quintiles): 1.31 [1.2, 1.43]Age, sex, follow up time—
PPM021387PSS011720|
Ancestry Not Reported|
23,594 individuals
PGP000650 |
Sjögren M et al. Int J Cardiol Heart Vasc (2019)
Reported Trait: Number of hospitilization days for any cause——Incidence Rate Ratio (IRR, top vs bottom PGS quintiles): 1.17 [1.08, 1.26]Age, sex, follow up time, hypertension, prevalent diabetes, smoking, ApoA1 and ApoB—
PPM021388PSS011720|
Ancestry Not Reported|
23,594 individuals
PGP000650 |
Sjögren M et al. Int J Cardiol Heart Vasc (2019)
Reported Trait: Any hospitilization event——Odds Ratio (OR, top vs bottom PGS quintiles): 1.18 [1.07, 1.3]Age, sex, follow up time—
PPM021389PSS011722|
Ancestry Not Reported|
23,594 individuals
PGP000650 |
Sjögren M et al. Int J Cardiol Heart Vasc (2019)
Reported Trait: Cardiovascular-related death——Hazard Ratio (HR, top vs bottom PGS quintiles): 1.44 [1.25, 1.66]Age, sex, hypertension, prevalent diabetes, smoking, aPoA1, ApoB—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011720Cases are individuals that were hospitilized at least once for any cause.Mean = 17.8 years
Sd = 4.4 years
[
  • 17,254 cases
  • , 6,340 controls
]
,
38.0 % Male samples
Mean = 58.0 years
Sd = 7.7 years		Not reported—MDC—
PSS011721Cases are individuals that were hospitilized at least once for a CVD event. The causes of hospitiliz... ation were classified according to ICD code as the main diagnosis at discharge. The most common causes of CVD hospitalizations were ischeamic heart disease (33%), stroke (23%), arterial fibrillation (15%) and congestive heart failure (3%) as estimated from the causes of the first hospitalization eventShow moreMean = 17.8 years
Sd = 4.4 years		23,594 individuals,
38.0 % Male samples
Mean = 58.0 years
Sd = 7.7 years		Not reported—MDC—
PSS011722——23,594 individuals,
38.0 % Male samples
Mean = 58.0 years
Sd = 7.7 years		Not reported—MDC—
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