Polygenic Score (PGS) ID: PGS004919

Predicted Trait
Reported Trait Coronary artery disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: June 12, 2024
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Score Details

Score Construction
PGS Name CAD_GRS_50
Development Method
Name Genome-wide significant variants
Parameters NR
Variants
Original Genome Build NR
Number of Variants 50
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000650
Citation (link to publication) Sjögren M et al. Int J Cardiol Heart Vasc (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 86.3%
South Asian: 13.7%
170,575 individuals (100%)
PGS Evaluation
Not Reported: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST000998
Europe PMC: 21378990
 86,995 individuals European 15 cohorts
  • ADVANCE
  • ,AtheroRemo 1
  • ,AtheroRemo 2
  • ,B58C
  • ,CADomics
  • ,CHARGE
  • ,GerMIFS
  • ,KORA
  • ,LURIC
  • ,MIGen
  • ,MedSTAR
  • ,OHGS
  • ,PennCATH
  • ,WTCCC
  • ,deCODE CAD
Europe PMC: 21966275
[
  • 11,202 cases
  • , 30,733 controls
]
 European 9 cohorts
  • ARIC
  • ,BHF-FHS
  • ,BLOODOMICS
  • ,CARDIA
  • ,CHS
  • ,FOS
  • ,KORA
  • ,PROCARDIS
  • ,PennCATH
Europe PMC: 21966275
[
  • 4,394 cases
  • , 4,259 controls
]
 South Asian LOLIPOP, PROMIS
GWAS Catalog: GCST000338
Europe PMC: 19198612
 2,520 individuals European GerMIFS
GWAS Catalog: GCST000999
Europe PMC: 21378988
 15,682 individuals European HPS, LOLIPOP, PROCARDIS, PROMIS
GWAS Catalog: GCST000999
Europe PMC: 21378988
 14,790 individuals South Asian
(India, Pakistan)		 HPS, LOLIPOP, PROCARDIS, PROMIS

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021385 PSS011720|
Ancestry Not Reported|
23,594 individuals
 PGP000650 |
Sjögren M et al. Int J Cardiol Heart Vasc (2019)
 Reported Trait: Number of hospitilizations for any cause — — Incidence Rate Ratio (IRR, top vs bottom PGS quintiles): 1.1 [1.04, 1.16] Age, sex, follow up time, hypertension, prevalent diabetes, smoking, ApoA1, ApoB —
PPM021386 PSS011721|
Ancestry Not Reported|
23,594 individuals
 PGP000650 |
Sjögren M et al. Int J Cardiol Heart Vasc (2019)
 Reported Trait: Number of cardiovascular-related hospitalizations — — Incidence Rate Ratio (IRR, top vs bottom PGS quintiles): 1.31 [1.2, 1.43] Age, sex, follow up time —
PPM021387 PSS011720|
Ancestry Not Reported|
23,594 individuals
 PGP000650 |
Sjögren M et al. Int J Cardiol Heart Vasc (2019)
 Reported Trait: Number of hospitilization days for any cause — — Incidence Rate Ratio (IRR, top vs bottom PGS quintiles): 1.17 [1.08, 1.26] Age, sex, follow up time, hypertension, prevalent diabetes, smoking, ApoA1 and ApoB —
PPM021388 PSS011720|
Ancestry Not Reported|
23,594 individuals
 PGP000650 |
Sjögren M et al. Int J Cardiol Heart Vasc (2019)
 Reported Trait: Any hospitilization event — — Odds Ratio (OR, top vs bottom PGS quintiles): 1.18 [1.07, 1.3] Age, sex, follow up time —
PPM021389 PSS011722|
Ancestry Not Reported|
23,594 individuals
 PGP000650 |
Sjögren M et al. Int J Cardiol Heart Vasc (2019)
 Reported Trait: Cardiovascular-related death — — Hazard Ratio (HR, top vs bottom PGS quintiles): 1.44 [1.25, 1.66] Age, sex, hypertension, prevalent diabetes, smoking, aPoA1, ApoB —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011722 — — 23,594 individuals,
38.0 % Male samples
 Mean = 58.0 years
Sd = 7.7 years		 Not reported — MDC —
PSS011720 Cases are individuals that were hospitilized at least once for any cause. Mean = 17.8 years
Sd = 4.4 years
[
  • 17,254 cases
  • , 6,340 controls
]
,
38.0 % Male samples
 Mean = 58.0 years
Sd = 7.7 years		 Not reported — MDC —
PSS011721 Cases are individuals that were hospitilized at least once for a CVD event. The causes of hospitilization were classified according to ICD code as the main diagnosis at discharge. The most common causes of CVD hospitalizations were ischeamic heart disease (33%), stroke (23%), arterial fibrillation (15%) and congestive heart failure (3%) as estimated from the causes of the first hospitalization event Mean = 17.8 years
Sd = 4.4 years		 23,594 individuals,
38.0 % Male samples
 Mean = 58.0 years
Sd = 7.7 years		 Not reported — MDC —