| Publication Information (EuropePMC) | |
| Title | Polygenetic risk for coronary artery disease increases hospitalization burden and mortality. |
| PubMed ID | 31360760(Europe PMC) |
| doi | 10.1016/j.ijcha.2019.100391 |
| Publication Date | July 16, 2019 |
| Journal | Int J Cardiol Heart Vasc |
| Author(s) | Sjögren M, Almgren P, Melander O. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS004919 (CAD_GRS_50) |
PGP000650 | Sjögren M et al. Int J Cardiol Heart Vasc (2019) |
Coronary artery disease | coronary artery disease | 50 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004919/ScoringFiles/PGS004919.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM021385 | PGS004919 (CAD_GRS_50) |
PSS011720| Ancestry Not Reported| 23,594 individuals |
PGP000650 | Sjögren M et al. Int J Cardiol Heart Vasc (2019) |
Reported Trait: Number of hospitilizations for any cause | — | — | Incidence Rate Ratio (IRR, top vs bottom PGS quintiles): 1.1 [1.04, 1.16] | Age, sex, follow up time, hypertension, prevalent diabetes, smoking, ApoA1, ApoB | — |
| PPM021386 | PGS004919 (CAD_GRS_50) |
PSS011721| Ancestry Not Reported| 23,594 individuals |
PGP000650 | Sjögren M et al. Int J Cardiol Heart Vasc (2019) |
Reported Trait: Number of cardiovascular-related hospitalizations | — | — | Incidence Rate Ratio (IRR, top vs bottom PGS quintiles): 1.31 [1.2, 1.43] | Age, sex, follow up time | — |
| PPM021387 | PGS004919 (CAD_GRS_50) |
PSS011720| Ancestry Not Reported| 23,594 individuals |
PGP000650 | Sjögren M et al. Int J Cardiol Heart Vasc (2019) |
Reported Trait: Number of hospitilization days for any cause | — | — | Incidence Rate Ratio (IRR, top vs bottom PGS quintiles): 1.17 [1.08, 1.26] | Age, sex, follow up time, hypertension, prevalent diabetes, smoking, ApoA1 and ApoB | — |
| PPM021388 | PGS004919 (CAD_GRS_50) |
PSS011720| Ancestry Not Reported| 23,594 individuals |
PGP000650 | Sjögren M et al. Int J Cardiol Heart Vasc (2019) |
Reported Trait: Any hospitilization event | — | — | Odds Ratio (OR, top vs bottom PGS quintiles): 1.18 [1.07, 1.3] | Age, sex, follow up time | — |
| PPM021389 | PGS004919 (CAD_GRS_50) |
PSS011722| Ancestry Not Reported| 23,594 individuals |
PGP000650 | Sjögren M et al. Int J Cardiol Heart Vasc (2019) |
Reported Trait: Cardiovascular-related death | — | — | Hazard Ratio (HR, top vs bottom PGS quintiles): 1.44 [1.25, 1.66] | Age, sex, hypertension, prevalent diabetes, smoking, aPoA1, ApoB | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011722 | — | — | 23,594 individuals, 38.0 % Male samples |
Mean = 58.0 years Sd = 7.7 years |
Not reported | — | MDC | — |
| PSS011720 | Cases are individuals that were hospitilized at least once for any cause. | Mean = 17.8 years Sd = 4.4 years |
[ ,
38.0 % Male samples |
Mean = 58.0 years Sd = 7.7 years |
Not reported | — | MDC | — |
| PSS011721 | Cases are individuals that were hospitilized at least once for a CVD event. The causes of hospitilization were classified according to ICD code as the main diagnosis at discharge. The most common causes of CVD hospitalizations were ischeamic heart disease (33%), stroke (23%), arterial fibrillation (15%) and congestive heart failure (3%) as estimated from the causes of the first hospitalization event | Mean = 17.8 years Sd = 4.4 years |
23,594 individuals, 38.0 % Male samples |
Mean = 58.0 years Sd = 7.7 years |
Not reported | — | MDC | — |