Polygenic Score (PGS) ID: PGS004926

Predicted Trait
Reported Trait Chronic back pain
Mapped Trait(s) Back pain (HP_0003418)
Released in PGS Catalog: July 31, 2024
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Score Details

Score Construction
PGS Name Back_3000
Development Method
Name SBayesR
Parameters NR
Variants
Original Genome Build NR
Number of Variants 1,090,574
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000661
Citation (link to publication) Tsepilov YA et al. J Pers Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
265,000 individuals (100%)
Score Development/Training
European: 100%
30,000 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 32587327
[
  • 47,507 cases
  • , 217,493 controls
]
,
46.0 % Male samples
 European UKB
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 30,000 individuals European UKB — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021708 PSS011757|
European Ancestry|
120,217 individuals
 PGP000661 |
Tsepilov YA et al. J Pers Med (2023)
 Reported Trait: Chronic back pain OR: 1.24 [1.22, 1.26] AUROC: 0.56 [0.557, 0.565] — — —
PPM021709 PSS011756|
European Ancestry|
2,654 individuals
 PGP000661 |
Tsepilov YA et al. J Pers Med (2023)
 Reported Trait: Lower back pain — AUROC: 0.58 [0.58, 0.59] — Age, sex —
PPM021710 PSS011756|
European Ancestry|
2,654 individuals
 PGP000661 |
Tsepilov YA et al. J Pers Med (2023)
 Reported Trait: Lower back pain OR: 1.21 [1.11, 1.32] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011756 — — 2,654 individuals — European — TwinsUK Lower back pain prevalence = 28%
PSS011757 — —
[
  • 21,543 cases
  • , 98,674 controls
]
 — European — UKB Chronic back pain prevalence = 18%