PGS Publication: PGP000661

Publication Information (EuropePMC)
Title Development and Replication of a Genome-Wide Polygenic Risk Score for Chronic Back Pain.
PubMed ID 37373966(Europe PMC)
doi 10.3390/jpm13060977
Publication Date June 10, 2023
Journal J Pers Med
Author(s) Tsepilov YA, Elgaeva EE, Nostaeva AV, Compte R, Kuznetsov IA, Karssen LC, Freidin MB, Suri P, Williams FMK, Aulchenko YS.
Released in PGS Catalog: July 31, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004926
(Back_3000)
 PGP000661 |
Tsepilov YA et al. J Pers Med (2023)
 Chronic back pain Back pain 1,090,574
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004926/ScoringFiles/PGS004926.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021708 PGS004926
(Back_3000)
 PSS011757|
European Ancestry|
120,217 individuals
 PGP000661 |
Tsepilov YA et al. J Pers Med (2023)
 Reported Trait: Chronic back pain OR: 1.24 [1.22, 1.26] AUROC: 0.56 [0.557, 0.565] — — —
PPM021709 PGS004926
(Back_3000)
 PSS011756|
European Ancestry|
2,654 individuals
 PGP000661 |
Tsepilov YA et al. J Pers Med (2023)
 Reported Trait: Lower back pain — AUROC: 0.58 [0.58, 0.59] — Age, sex —
PPM021710 PGS004926
(Back_3000)
 PSS011756|
European Ancestry|
2,654 individuals
 PGP000661 |
Tsepilov YA et al. J Pers Med (2023)
 Reported Trait: Lower back pain OR: 1.21 [1.11, 1.32] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011756 — — 2,654 individuals — European — TwinsUK Lower back pain prevalence = 28%
PSS011757 — —
[
  • 21,543 cases
  • , 98,674 controls
]
 — European — UKB Chronic back pain prevalence = 18%