Polygenic Score (PGS) ID: PGS004945

Predicted Trait
Reported Trait Colorectal cancer
Mapped Trait(s) colorectal cancer (MONDO_0005575)
Released in PGS Catalog: Aug. 29, 2024
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Score Details

Score Construction
PGS Name PRS87_CRC
Development Method
Name Genome-wide significant SNPs
Parameters p < 5E-08, r2 < 0.01
Variants
Original Genome Build NR
Number of Variants 87
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000671
Citation (link to publication) Gao P et al. Int J Cancer (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 95.8%
East Asian: 4.2%
125,478 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007856
Europe PMC: 30510241
 120,184 individuals European NR
GWAS Catalog: GCST007856
Europe PMC: 30510241
 5,294 individuals East Asian NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021752 PSS011779|
European Ancestry|
306,857 individuals
 PGP000671 |
Gao P et al. Int J Cancer (2023)
 Reported Trait: Incident colorectal cancer — — Hazard ratio (HR, top vs bottom PGS tertile): 2.35 [2.11, 2.6] Age, sex, ethnic, college or university degree, Townsend deprivation index, alcohol drinking, smoking status, BMI, protein diet, regular physical activity, sleep duration, hyperlipidemia, hypertension, T2D, triglycerides, total cholesterol, glucose, eGFR, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011779 — — 306,857 individuals — European — UKB —