Polygenic Score (PGS) ID: PGS004945

Predicted Trait
Reported Trait Colorectal cancer
Mapped Trait(s) colorectal cancer (MONDO_0005575)
Released in PGS Catalog: Aug. 29, 2024
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS87_CRC
Development Method
Name Genome-wide significant SNPs
Parameters p < 5E-08, r2 < 0.01
Variants
Original Genome Build NR
Number of Variants 87
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000671
Citation (link to publication) Gao P et al. Int J Cancer (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 95.8%
East Asian: 4.2%
125,478 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST007856
Europe PMC: 30510241
120,184 individualsEuropeanNR
GWAS Catalog: GCST007856
Europe PMC: 30510241
5,294 individualsEast AsianNR
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM021752PSS011779|
European Ancestry|
306,857 individuals
PGP000671 |
Gao P et al. Int J Cancer (2023)
Reported Trait: Incident colorectal cancer——Hazard ratio (HR, top vs bottom PGS tertile): 2.35 [2.11, 2.6]Age, sex, ethnic, college or university degree, Townsend deprivation index, alcohol drinking, smokin... g status, BMI, protein diet, regular physical activity, sleep duration, hyperlipidemia, hypertension, T2D, triglycerides, total cholesterol, glucose, eGFR, genotyping array, 10 PCsShow more—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011779——306,857 individuals—European—UKB—
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