PGS Publication: PGP000671

Publication Information (EuropePMC)
Title Association between serum urea concentrations and the risk of colorectal cancer, particularly in individuals with type 2 diabetes: A cohort study.
PubMed ID 37671773(Europe PMC)
doi 10.1002/ijc.34719
Publication Date Sept. 6, 2023
Journal Int J Cancer
Author(s) Gao P, Mei Z, Liu Z, Zhu D, Yuan H, Zhao R, Xu K, Zhang T, Jiang Y, Suo C, Chen X.
Released in PGS Catalog: Aug. 29, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004945
(PRS87_CRC)
 PGP000671 |
Gao P et al. Int J Cancer (2023)
 Colorectal cancer colorectal cancer 87
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004945/ScoringFiles/PGS004945.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021752 PGS004945
(PRS87_CRC)
 PSS011779|
European Ancestry|
306,857 individuals
 PGP000671 |
Gao P et al. Int J Cancer (2023)
 Reported Trait: Incident colorectal cancer — — Hazard ratio (HR, top vs bottom PGS tertile): 2.35 [2.11, 2.6] Age, sex, ethnic, college or university degree, Townsend deprivation index, alcohol drinking, smoking status, BMI, protein diet, regular physical activity, sleep duration, hyperlipidemia, hypertension, T2D, triglycerides, total cholesterol, glucose, eGFR, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011779 — — 306,857 individuals — European — UKB —