Polygenic Score (PGS) ID: PGS004954

Predicted Trait
Reported Trait Thyroid cancer
Mapped Trait(s) thyroid carcinoma (EFO_0002892)
Released in PGS Catalog: Sept. 19, 2024
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Score Details

Score Construction
PGS Name PRS26_TC
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 26
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000676
Citation (link to publication) Pozdeyev N et al. J Clin Endocrinol Metab (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 82.7%
East Asian: 15.7%
African: 0.9%
Hispanic or Latin American: 0.7%
1,620,354 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • African
  • Additional Asian Ancestries
  • European
  • Additional Diverse Ancestries
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90399737
Europe PMC: 36777996
 11,121 individuals Hispanic or Latin American NR
GWAS Catalog: GCST90399737
Europe PMC: 36777996
 14,847 individuals African unspecified NR
GWAS Catalog: GCST90399737
Europe PMC: 36777996
 254,617 individuals East Asian NR
GWAS Catalog: GCST90399737
Europe PMC: 36777996
 1,339,769 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021769 PSS011791|
Multi-ancestry (including European)|
73,346 individuals
 PGP000676 |
Pozdeyev N et al. J Clin Endocrinol Metab (2024)
 Reported Trait: Thyroid cancer — AUROC: 0.7 — Age, sex, genotyping batch, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011791 — — 73,346 individuals — African American or Afro-Caribbean, Asian unspecified, European, Native American, Not reported — CCPM —