PGS Publication: PGP000676

Publication Information (EuropePMC)
Title Thyroid Cancer Polygenic Risk Score Improves Classification of Thyroid Nodules as Benign or Malignant.
PubMed ID 37683082(Europe PMC)
doi 10.1210/clinem/dgad530
Publication Date Jan. 1, 2024
Journal J Clin Endocrinol Metab
Author(s) Pozdeyev N, Dighe M, Barrio M, Raeburn C, Smith H, Fisher M, Chavan S, Rafaels N, Shortt JA, Lin M, Leu MG, Clark T, Marshall C, Haugen BR, Subramanian D, Crooks K, Gignoux C, Cohen T.
Released in PGS Catalog: Sept. 19, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004954
(PRS26_TC)
 PGP000676 |
Pozdeyev N et al. J Clin Endocrinol Metab (2024)
 Thyroid cancer thyroid carcinoma 26
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004954/ScoringFiles/PGS004954.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021769 PGS004954
(PRS26_TC)
 PSS011791|
Multi-ancestry (including European)|
73,346 individuals
 PGP000676 |
Pozdeyev N et al. J Clin Endocrinol Metab (2024)
 Reported Trait: Thyroid cancer — AUROC: 0.7 — Age, sex, genotyping batch, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011791 — — 73,346 individuals — African American or Afro-Caribbean, Asian unspecified, European, Native American, Not reported — CCPM —