Polygenic Score (PGS) ID: PGS005076

Predicted Trait
Reported Trait Congestive heart failure (CHF), NOS (PheCode 428.1)
Mapped Trait(s) congestive heart failure (EFO_0000373)
Released in PGS Catalog: Oct. 8, 2024
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name Phe_428_1_ldpred_METAss_afrld
Development Method
Name ldpred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 1,286,612
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000679
Citation (link to publication) Gunn S et al. HGG Adv (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 50.3%
European: 36%
African: 9.6%
Hispanic or Latin American: 4.1%
1,212,139 individuals (100%)
PGS Evaluation
African: 33.3%
Hispanic or Latin American: 33.3%
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
—
[
  • 15,411 cases
  • , 100,787 controls
]
African American or Afro-CaribbeanMVP
—
[
  • 59,453 cases
  • , 377,030 controls
]
EuropeanMVP
—
[
  • 3,946 cases
  • , 45,502 controls
]
Hispanic or Latin AmericanMVP
—
[
  • 79,201 cases
  • , 530,809 controls
]
Not reportedMVP
Showing 1 to 4 of 4 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM021953PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
PGP000679 |
Gunn S et al. HGG Adv (2024)
Reported Trait: Congestive heart failure (CHF), NOSOR: 1.354 [1.17, 1.57]C-index: 0.79231—age, sex, 20 PCs—
PPM021959PSS011821|
European Ancestry|
31,804 individuals
PGP000679 |
Gunn S et al. HGG Adv (2024)
Reported Trait: Congestive heart failure (CHF), NOSOR: 1.443 [1.37, 1.52]C-index: 0.75325—age, sex, 20 PCs—
PPM021965PSS011801|
African Ancestry|
10,682 individuals
PGP000679 |
Gunn S et al. HGG Adv (2024)
Reported Trait: Congestive heart failure (CHF), NOSOR: 1.369 [1.23, 1.52]C-index: 0.71935—age, sex, 20 PCs—
Showing 1 to 3 of 3 rows

Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011801——
[
  • 741 cases
  • , 9,941 controls
]
—African American or Afro-Caribbean—AllofUs—
PSS011811——
[
  • 315 cases
  • , 7,804 controls
]
—Hispanic or Latin American—AllofUs—
PSS011821——
[
  • 1,687 cases
  • , 30,117 controls
]
—European—AllofUs—
Showing 1 to 3 of 3 rows