Polygenic Score (PGS) ID: PGS005076

Predicted Trait
Reported Trait Congestive heart failure (CHF), NOS (PheCode 428.1)
Mapped Trait(s) congestive heart failure (EFO_0000373)
Released in PGS Catalog: Oct. 8, 2024
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Score Details

Score Construction
PGS Name Phe_428_1_ldpred_METAss_afrld
Development Method
Name ldpred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 1,286,612
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000679
Citation (link to publication) Gunn S et al. HGG Adv (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 50.3%
European: 36%
African: 9.6%
Hispanic or Latin American: 4.1%
1,212,139 individuals (100%)
PGS Evaluation
African: 33.3%
Hispanic or Latin American: 33.3%
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 15,411 cases
  • , 100,787 controls
]
 African American or Afro-Caribbean MVP
—
[
  • 59,453 cases
  • , 377,030 controls
]
 European MVP
—
[
  • 3,946 cases
  • , 45,502 controls
]
 Hispanic or Latin American MVP
—
[
  • 79,201 cases
  • , 530,809 controls
]
 Not reported MVP

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021953 PSS011811|
Hispanic or Latin American Ancestry|
8,119 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.354 [1.17, 1.57] C-index: 0.79231 — age, sex, 20 PCs —
PPM021965 PSS011801|
African Ancestry|
10,682 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.369 [1.23, 1.52] C-index: 0.71935 — age, sex, 20 PCs —
PPM021959 PSS011821|
European Ancestry|
31,804 individuals
 PGP000679 |
Gunn S et al. HGG Adv (2024)
 Reported Trait: Congestive heart failure (CHF), NOS OR: 1.443 [1.37, 1.52] C-index: 0.75325 — age, sex, 20 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011801 — —
[
  • 741 cases
  • , 9,941 controls
]
 — African American or Afro-Caribbean — AllofUs —
PSS011811 — —
[
  • 315 cases
  • , 7,804 controls
]
 — Hispanic or Latin American — AllofUs —
PSS011821 — —
[
  • 1,687 cases
  • , 30,117 controls
]
 — European — AllofUs —