Polygenic Score (PGS) ID: PGS005158

Predicted Trait
Reported Trait Peripheral artery disease
Mapped Trait(s) peripheral arterial disease (EFO_0004265)
Released in PGS Catalog: Feb. 26, 2025
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS19_PAD
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 19
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000705
Citation (link to publication) Zhu K et al. Diabetes Care (2024)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 72%
African: 19.7%
Hispanic or Latin American: 8.3%
243,060 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008474
Europe PMC: 31285632
 174,992 individuals European NR
GWAS Catalog: GCST008474
Europe PMC: 31285632
 47,858 individuals African unspecified NR
GWAS Catalog: GCST008474
Europe PMC: 31285632
 20,210 individuals Hispanic or Latin American NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022379 PSS011930|
European Ancestry|
10,836 individuals
 PGP000705 |
Zhu K et al. Diabetes Care (2024)
 Reported Trait: Peripheral artery disease in type 2 diabetes x lifestyle interaction — — Hazard ratio (HR, unfavorable lifestyle and high PRS vs. favorable life style and low PRS): 5.03 [2.74, 9.22] age (continuous, years), sex (male, female), education attainment (college or university degree, A/AS levels or equivalent or O levels/ GCSEs or equivalent or other professional qualifications, or none of the above), Townsend Deprivation Index (continuous), family history of CVD (yes, no), prevalence of hypertension (yes, no), use of antihypertensive medication (yes, no), use of lipid-lowing medication (yes, no), aspirin use (yes, no), diabetes duration (continuous, years), HbA1c (continuous, %), use of diabetes medication (none, only oral medication pills, only insulin, or combination of oral medications and insulin), genotype measurement batch, and the first 10 principal components of ancestry fig 1
PPM022378 PSS011930|
European Ancestry|
10,836 individuals
 PGP000705 |
Zhu K et al. Diabetes Care (2024)
 Reported Trait: Peripheral artery disease in type 2 diabetes HR: 1.13 [1.03, 1.23] — — age (continuous, years), sex (male, female), Townsend Deprivation Index (continuous), race/ethnicity (White, others), education attainment (college or university degree, A/AS levels or equivalent or O levels/GCSEs or equivalent or other professional qualifications, or none of the above), family history of CVD (yes, no), prevalence of hypertension (yes, no), use of antihypertensive medication (yes, no), use of lipidlowing medication (yes, no), use of aspirin (yes, no), diabetes duration (continuous, years), HbA1c (continuous, %), use of diabetes medication (none, only oral medication pills, or only insulin or combination of oral medications and insulin), genotype measurement batch, the first 10 principal components of ancestry, weighted healthy lifestyle scores (continuous) ST3

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011930 — — 10,836 individuals — European
(British)		 — UKB —