| Publication Information (EuropePMC) | |
| Title | Modifiable Lifestyle Factors, Genetic Risk, and Incident Peripheral Artery Disease Among Individuals With Type 2 Diabetes: A Prospective Study. |
| PubMed ID | 38181303(Europe PMC) |
| doi | 10.2337/dc23-1503 |
| Publication Date | March 1, 2024 |
| Journal | Diabetes Care |
| Author(s) | Zhu K, Qian F, Lu Q, Li R, Qiu Z, Li L, Li R, Yu H, Deng Y, Yang K, Pan A, Liu G. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS005158 (PRS19_PAD) |
PGP000705 | Zhu K et al. Diabetes Care (2024) |
Peripheral artery disease | peripheral arterial disease | 19 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005158/ScoringFiles/PGS005158.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM022379 | PGS005158 (PRS19_PAD) |
PSS011930| European Ancestry| 10,836 individuals |
PGP000705 | Zhu K et al. Diabetes Care (2024) |
Reported Trait: Peripheral artery disease in type 2 diabetes x lifestyle interaction | — | — | Hazard ratio (HR, unfavorable lifestyle and high PRS vs. favorable life style and low PRS): 5.03 [2.74, 9.22] | age (continuous, years), sex (male, female), education attainment (college or university degree, A/AS levels or equivalent or O levels/ GCSEs or equivalent or other professional qualifications, or none of the above), Townsend Deprivation Index (continuous), family history of CVD (yes, no), prevalence of hypertension (yes, no), use of antihypertensive medication (yes, no), use of lipid-lowing medication (yes, no), aspirin use (yes, no), diabetes duration (continuous, years), HbA1c (continuous, %), use of diabetes medication (none, only oral medication pills, only insulin, or combination of oral medications and insulin), genotype measurement batch, and the first 10 principal components of ancestry | fig 1 |
| PPM022378 | PGS005158 (PRS19_PAD) |
PSS011930| European Ancestry| 10,836 individuals |
PGP000705 | Zhu K et al. Diabetes Care (2024) |
Reported Trait: Peripheral artery disease in type 2 diabetes | HR: 1.13 [1.03, 1.23] | — | — | age (continuous, years), sex (male, female), Townsend Deprivation Index (continuous), race/ethnicity (White, others), education attainment (college or university degree, A/AS levels or equivalent or O levels/GCSEs or equivalent or other professional qualifications, or none of the above), family history of CVD (yes, no), prevalence of hypertension (yes, no), use of antihypertensive medication (yes, no), use of lipidlowing medication (yes, no), use of aspirin (yes, no), diabetes duration (continuous, years), HbA1c (continuous, %), use of diabetes medication (none, only oral medication pills, or only insulin or combination of oral medications and insulin), genotype measurement batch, the first 10 principal components of ancestry, weighted healthy lifestyle scores (continuous) | ST3 |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011930 | — | — | 10,836 individuals | — | European (British) |
— | UKB | — |