Polygenic Score (PGS) ID: PGS005169

Predicted Trait
Reported Trait Lung adenocarcinoma
Mapped Trait(s) lung adenocarcinoma (EFO_0000571)
Released in PGS Catalog: March 17, 2025
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS25_LUAD
Development Method
Name genome-wide significant SNPs
Parameters p=5E-08
Variants
Original Genome Build GRCh37
Number of Variants 25
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000713
Citation (link to publication) Blechter B et al. JAMA Netw Open (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
42,315 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90297562
Europe PMC: 37236969
 42,315 individuals East Asian FLCCA, NR, Other

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022451 PSS011947|
East Asian Ancestry|
2,048 individuals
 PGP000713 |
Blechter B et al. JAMA Netw Open (2023)
 Reported Trait: Lung adenocarcinoma OR: 1.6 [1.46, 1.75] — — — —
PPM022452 PSS011947|
East Asian Ancestry|
2,048 individuals
 PGP000713 |
Blechter B et al. JAMA Netw Open (2023)
 Reported Trait: Lung adenocarcinoma x Environmental Tobacco Smoke interaction — — p-value (p, Environmental Tobacco Smoke at home and at work and high PRS vs Environmental Tobacco Smoke never and low PRS): 0.00065 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011947 — —
[
  • 1,024 cases
  • , 1,024 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — GELAC —