PGS Publication: PGP000713

Publication Information (EuropePMC)
Title Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan.
PubMed ID 37955902(Europe PMC)
doi 10.1001/jamanetworkopen.2023.39254
Publication Date Nov. 1, 2023
Journal JAMA Netw Open
Author(s) Blechter B, Chien LH, Chen TY, Chang IS, Choudhury PP, Hsiao CF, Shu XO, Wong JYY, Chen KY, Chang GC... , Tsai YH, Su WC, Huang MS, Chen YM, Chen CY, Hung HH, Hu JW, Shi J, Zheng W, Rositch AF, Chen CJ, Chatterjee N, Yang PC, Rothman N, Hsiung CA, Lan Q.Show more
Released in PGS Catalog: March 17, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

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Polygenic Score ID & Name
PGS Publication ID (PGP)
Reported Trait
Mapped Trait(s) (Ontology)
Number of Variants
Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS005169
(PRS25_LUAD)
PGP000713 |
Blechter B et al. JAMA Netw Open (2023)
Lung adenocarcinomalung adenocarcinoma25
G
-
E
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005169/ScoringFiles/PGS005169.txt.gz
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
Evaluated Score
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM022451PGS005169
(PRS25_LUAD)
PSS011947|
East Asian Ancestry|
2,048 individuals
PGP000713 |
Blechter B et al. JAMA Netw Open (2023)
Reported Trait: Lung adenocarcinomaOR: 1.6 [1.46, 1.75]————
PPM022452PGS005169
(PRS25_LUAD)
PSS011947|
East Asian Ancestry|
2,048 individuals
PGP000713 |
Blechter B et al. JAMA Netw Open (2023)
Reported Trait: Lung adenocarcinoma x Environmental Tobacco Smoke interaction——p-value (p, Environmental Tobacco Smoke at home and at work and high PRS vs Environmental Tobacco Smoke never and low PRS): 0.00065——
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS011947——
[
  • 1,024 cases
  • , 1,024 controls
]
,
0.0 % Male samples
—East Asian
(Han Chinese)		—GELAC—
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