PGS Publication: PGP000713

Publication Information (EuropePMC)
Title Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan.
PubMed ID 37955902(Europe PMC)
doi 10.1001/jamanetworkopen.2023.39254
Publication Date Nov. 1, 2023
Journal JAMA Netw Open
Author(s) Blechter B, Chien LH, Chen TY, Chang IS, Choudhury PP, Hsiao CF, Shu XO, Wong JYY, Chen KY, Chang GC, Tsai YH, Su WC, Huang MS, Chen YM, Chen CY, Hung HH, Hu JW, Shi J, Zheng W, Rositch AF, Chen CJ, Chatterjee N, Yang PC, Rothman N, Hsiung CA, Lan Q.
Released in PGS Catalog: March 17, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005169
(PRS25_LUAD)
 PGP000713 |
Blechter B et al. JAMA Netw Open (2023)
 Lung adenocarcinoma lung adenocarcinoma 25
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005169/ScoringFiles/PGS005169.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022451 PGS005169
(PRS25_LUAD)
 PSS011947|
East Asian Ancestry|
2,048 individuals
 PGP000713 |
Blechter B et al. JAMA Netw Open (2023)
 Reported Trait: Lung adenocarcinoma OR: 1.6 [1.46, 1.75] — — — —
PPM022452 PGS005169
(PRS25_LUAD)
 PSS011947|
East Asian Ancestry|
2,048 individuals
 PGP000713 |
Blechter B et al. JAMA Netw Open (2023)
 Reported Trait: Lung adenocarcinoma x Environmental Tobacco Smoke interaction — — p-value (p, Environmental Tobacco Smoke at home and at work and high PRS vs Environmental Tobacco Smoke never and low PRS): 0.00065 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011947 — —
[
  • 1,024 cases
  • , 1,024 controls
]
,
0.0 % Male samples
 — East Asian
(Han Chinese)		 — GELAC —