Trait: nicotine dependence

Experimental Factor Ontology (EFO) Information
Identifier EFO_0003768
Description Physical and psychological dependence on nicotine. [NCIT: C54203]
Trait category
Neurological disorder
Synonyms 26 synonyms
  • Cigarette Smoking
  • Dependence, Nicotine
  • Dependence, Tobacco
  • Disorder, Nicotine Use
  • Disorder, Tobacco Use
  • Disorder, Tobacco-Use
  • NICOTINE USE DIS
  • Nicotine Addiction
  • Nicotine Use Disorder
  • Nicotine Use Disorders
  • Smoking, Cigarette
  • Smoking, Tobacco
  • Smokings, Tobacco
  • TOBACCO USE DIS
  • Tobacco Dependence
  • Tobacco Dependences
  • Tobacco Smoking
  • Tobacco Smokings
  • Tobacco Use Disorder
  • Tobacco Use Disorders
  • Tobacco-Use Disorder
  • Use Disorder, Nicotine
  • nicotine addiction
  • nicotine dependence
  • smoking
  • tobacco use disorder
Mapped terms 16 mapped terms
  • DOID:0050742
  • ICD10:F17
  • ICD10CM:F17
  • ICD9:305.1
  • MEDGEN:45086
  • MESH:D014029
  • MONDO:0008575
  • MeSH:D012907
  • MeSH:D014029
  • MedDRA:10057852
  • NCIT:C54203
  • NCIt:C54203
  • SCTID:56294008
  • SNOMEDCT:56294008
  • UMLS:C0028043
  • icd11.foundation:1699574100

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001830
(portability-PLR_318)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Tobacco use disorder nicotine dependence 13,838
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001830/ScoringFiles/PGS001830.txt.gz
PGS002037
(portability-ldpred2_318)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Tobacco use disorder nicotine dependence 847,691
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002037/ScoringFiles/PGS002037.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009533 PGS001830
(portability-PLR_318)
 PSS009300|
European Ancestry|
19,400 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0557 [0.0416, 0.0697] sex, age, birth date, deprivation index, 16 PCs —
PPM009534 PGS001830
(portability-PLR_318)
 PSS009074|
European Ancestry|
4,022 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0092 [-0.0218, 0.0401] sex, age, birth date, deprivation index, 16 PCs —
PPM009535 PGS001830
(portability-PLR_318)
 PSS008628|
European Ancestry|
6,548 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0603 [0.0361, 0.0845] sex, age, birth date, deprivation index, 16 PCs —
PPM009536 PGS001830
(portability-PLR_318)
 PSS008402|
Greater Middle Eastern Ancestry|
1,180 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0076 [-0.05, 0.0651] sex, age, birth date, deprivation index, 16 PCs —
PPM009537 PGS001830
(portability-PLR_318)
 PSS008182|
South Asian Ancestry|
6,249 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0361 [0.0113, 0.0609] sex, age, birth date, deprivation index, 16 PCs —
PPM009538 PGS001830
(portability-PLR_318)
 PSS007967|
East Asian Ancestry|
1,800 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0404 [-0.0061, 0.0867] sex, age, birth date, deprivation index, 16 PCs —
PPM009539 PGS001830
(portability-PLR_318)
 PSS007748|
African Ancestry|
2,445 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): -0.0084 [-0.0482, 0.0314] sex, age, birth date, deprivation index, 16 PCs —
PPM009540 PGS001830
(portability-PLR_318)
 PSS008852|
African Ancestry|
3,876 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0032 [-0.0284, 0.0347] sex, age, birth date, deprivation index, 16 PCs —
PPM011163 PGS002037
(portability-ldpred2_318)
 PSS009300|
European Ancestry|
19,400 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0741 [0.0601, 0.0881] sex, age, birth date, deprivation index, 16 PCs —
PPM011164 PGS002037
(portability-ldpred2_318)
 PSS009074|
European Ancestry|
4,022 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0253 [-0.0056, 0.0563] sex, age, birth date, deprivation index, 16 PCs —
PPM011166 PGS002037
(portability-ldpred2_318)
 PSS008402|
Greater Middle Eastern Ancestry|
1,180 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.043 [-0.0146, 0.1003] sex, age, birth date, deprivation index, 16 PCs —
PPM011167 PGS002037
(portability-ldpred2_318)
 PSS008182|
South Asian Ancestry|
6,249 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0598 [0.035, 0.0845] sex, age, birth date, deprivation index, 16 PCs —
PPM011168 PGS002037
(portability-ldpred2_318)
 PSS007967|
East Asian Ancestry|
1,800 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0244 [-0.0221, 0.0708] sex, age, birth date, deprivation index, 16 PCs —
PPM011169 PGS002037
(portability-ldpred2_318)
 PSS007748|
African Ancestry|
2,445 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0244 [-0.0154, 0.0642] sex, age, birth date, deprivation index, 16 PCs —
PPM011170 PGS002037
(portability-ldpred2_318)
 PSS008852|
African Ancestry|
3,876 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): -0.0199 [-0.0514, 0.0117] sex, age, birth date, deprivation index, 16 PCs —
PPM011165 PGS002037
(portability-ldpred2_318)
 PSS008628|
European Ancestry|
6,548 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Tobacco use disorder — — Partial Correlation (partial-r): 0.0812 [0.0571, 0.1053] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007748 — — 2,445 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008402 — — 1,180 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009074 — — 4,022 individuals — European Poland (NE Europe) UKB —
PSS009300 — — 19,400 individuals — European UK (+ Ireland) UKB —
PSS008628 — — 6,548 individuals — European Italy (South Europe) UKB —
PSS008182 — — 6,249 individuals — South Asian India (South Asia) UKB —
PSS008852 — — 3,876 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007967 — — 1,800 individuals — East Asian China (East Asia) UKB —