Trait: bone quantitative ultrasound measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004514
Description A bone quantitative ultrasound measurement is the output of a an ultrasound process in which bones are assayed using ultrasound and information about bone density, cortical thickness, elasticity and microarchitecture may be returned.
Trait category
Other measurement
Synonyms 2 synonyms
  • bone quantitative ultrasound
  • broadband ultrasound attenuation
Child trait(s) calcaneal bone quantitative ultrasound measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "bone quantitative ultrasound measurement" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000657
(gSOS)
 PGP000120 |
Forgetta V et al. PLoS Med (2020)
 Heel quantitative ultrasound speed of sound (SOS) calcaneal bone quantitative ultrasound measurement 21,716
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000657/ScoringFiles/PGS000657.txt.gz - Check Terms/Licenses
PGS000951
(GBE_INI3144)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Heel Broadband ultrasound attenuation, direct entry bone quantitative ultrasound measurement 13,735
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000951/ScoringFiles/PGS000951.txt.gz
PGS000952
(GBE_INI3147)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Heel quantitative ultrasound index (QUI), direct entry bone quantitative ultrasound measurement 14,311
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000952/ScoringFiles/PGS000952.txt.gz
PGS000953
(GBE_INI4101)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Left heel broadband ultrasound attenuation bone quantitative ultrasound measurement 7,688
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000953/ScoringFiles/PGS000953.txt.gz
PGS000954
(GBE_INI4104)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Left heel quantitative ultrasound index (QUI), direct entry bone quantitative ultrasound measurement 9,272
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000954/ScoringFiles/PGS000954.txt.gz
PGS000955
(GBE_INI4120)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Right heel broadband ultrasound attenuation bone quantitative ultrasound measurement 7,069
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000955/ScoringFiles/PGS000955.txt.gz
PGS000956
(GBE_INI4123)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Right heel quantitative ultrasound index (QUI), direct entry bone quantitative ultrasound measurement 9,756
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000956/ScoringFiles/PGS000956.txt.gz
PGS001529
(GBE_INI3146)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Speed of sound through heel calcaneal bone quantitative ultrasound measurement 13,172
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001529/ScoringFiles/PGS001529.txt.gz
PGS001530
(GBE_INI4103)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Speed of sound through heel (L) calcaneal bone quantitative ultrasound measurement 8,419
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001530/ScoringFiles/PGS001530.txt.gz
PGS001531
(GBE_INI4122)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Speed of sound through heel (R) calcaneal bone quantitative ultrasound measurement 8,912
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001531/ScoringFiles/PGS001531.txt.gz
PGS001956
(portability-PLR_log_heel_BUA)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Heel Broadband ultrasound attenuation, direct entry calcaneal bone quantitative ultrasound measurement 69,537
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001956/ScoringFiles/PGS001956.txt.gz
PGS002174
(portability-ldpred2_log_heel_BUA)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Heel Broadband ultrasound attenuation, direct entry calcaneal bone quantitative ultrasound measurement 732,595
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002174/ScoringFiles/PGS002174.txt.gz
PGS003536
(cont-decay-log_heel_BUA)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Heel Broadband ultrasound attenuation, direct entry bone quantitative ultrasound measurement 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003536/ScoringFiles/PGS003536.txt.gz
PGS004413
(X3144.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel Broadband ultrasound attenuation, direct entry bone quantitative ultrasound measurement 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004413/ScoringFiles/PGS004413.txt.gz
PGS004414
(X3147.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel quantitative ultrasound index (QUI), direct entry bone quantitative ultrasound measurement 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004414/ScoringFiles/PGS004414.txt.gz
PGS004417
(X4101.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel broadband ultrasound attenuation (left) bone quantitative ultrasound measurement 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004417/ScoringFiles/PGS004417.txt.gz
PGS004418
(X4104.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel quantitative ultrasound index (QUI), direct entry (left) bone quantitative ultrasound measurement 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004418/ScoringFiles/PGS004418.txt.gz
PGS004422
(X4120.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel broadband ultrasound attenuation (right) bone quantitative ultrasound measurement 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004422/ScoringFiles/PGS004422.txt.gz
PGS004423
(X4123.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Heel quantitative ultrasound index (QUI), direct entry (right) bone quantitative ultrasound measurement 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004423/ScoringFiles/PGS004423.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001343 PGS000657
(gSOS)
 PSS000586|
European Ancestry|
80,027 individuals
 PGP000120 |
Forgetta V et al. PLoS Med (2020)
 Reported Trait: Heel bone speed of sound — — R²: 0.2318 [0.2266, 0.2369] — —
PPM001344 PGS000657
(gSOS)
 PSS000585|
Multi-ancestry (including European)|
21,408 individuals
 PGP000120 |
Forgetta V et al. PLoS Med (2020)
 Reported Trait: Screening incorporating a gSOS-based screening step — — Positive Predictive Value (PPV): 0.954
Reduction in individuals requiring Clinical-Risk-Factor FRAX tests (%): 37.0
Percent reduction in individuals requiring BMD FRAX Tests (%): 41.0		 — —
PPM001862 PGS000657
(gSOS)
 PSS000950|
European Ancestry|
90,172 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture — AUROC: 0.798 [0.791, 0.805] Odds ratio (OR, bottom 25% vs. remaining 75%): 1.2 [1.02, 1.41] Age, sex —
PPM001863 PGS000657
(gSOS)
 PSS000944|
European Ancestry|
8,278 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture — C-index: 0.623 [0.603, 0.642] — Sex —
PPM001864 PGS000657
(gSOS)
 PSS000943|
European Ancestry|
8,278 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture — C-index: 0.672 [0.65, 0.695] — Sex —
PPM001861 PGS000657
(gSOS)
 PSS000951|
European Ancestry|
90,172 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture — AUROC: 0.734 [0.727, 0.74] Odds ratio (OR, bottom 25% vs. remaining 75%): 1.68 [1.47, 1.89] Age, sex —
PPM001867 PGS000657
(gSOS)
 PSS000942|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.66, 0.79] — — Age, sex —
PPM001852 PGS000657
(gSOS)
 PSS000937|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.69 [0.65, 0.71] — — — —
PPM001853 PGS000657
(gSOS)
 PSS000937|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.68 [0.64, 0.73] — Odds ratio (OR, bottom 50% vs top 50%): 1.86 [1.62, 2.13] Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS —
PPM001854 PGS000657
(gSOS)
 PSS000936|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.67, 0.87] — Odds ratio (OR, bottom 50% vs top 50%): 1.42 [1.08, 1.88] Basline fracture risk (FRAX), fracture-related drug use —
PPM001855 PGS000657
(gSOS)
 PSS000936|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.74 [0.64, 0.78] — — — —
PPM001856 PGS000657
(gSOS)
 PSS000936|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.64, 0.89] — — Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS —
PPM001857 PGS000657
(gSOS)
 PSS000933|
European Ancestry|
12,678 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture in fracture-related drug users OR: 0.78 [0.68, 0.88] — Odds ratio (OR, bottom 50% vs top 50%): 1.54 [1.19, 1.99] Basline fracture risk (FRAX) —
PPM001858 PGS000657
(gSOS)
 PSS000932|
European Ancestry|
12,678 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: incident hip fracture in fracture-related drug users OR: 0.77 [0.61, 0.98] — Odds ratio (OR, bottom 50% vs top 50%): 1.99 [1.19, 3.31] Basline fracture risk (FRAX) —
PPM001859 PGS000657
(gSOS)
 PSS000935|
European Ancestry|
67,336 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture in individuals who don’t use fracture-related drugs OR: 0.57 [0.54, 0.61] — Odds ratio (OR, bottom 50% vs top 50%): 1.75 [1.65, 1.86] Basline fracture risk (FRAX) —
PPM001860 PGS000657
(gSOS)
 PSS000934|
European Ancestry|
67,336 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident hip fracture in individuals who don’t use fracture-related drugs OR: 0.36 [0.3, 0.43] — Odds ratio (OR, bottom 50% vs top 50%): 2.81 [2.35, 3.36] Basline fracture risk (FRAX) —
PPM001865 PGS000657
(gSOS)
 PSS000948|
European Ancestry|
80,014 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.68 [0.65, 0.72] AUROC: 0.68 [0.673, 0.688] — Age, sex —
PPM001868 PGS000657
(gSOS)
 PSS000942|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.76 [0.69, 0.85] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001869 PGS000657
(gSOS)
 PSS000940|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.69 [0.61, 0.78] — — Age, sex —
PPM001870 PGS000657
(gSOS)
 PSS000940|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.61, 0.85] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001871 PGS000657
(gSOS)
 PSS000946|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.74 [0.68, 0.81] — — Age, sex —
PPM001872 PGS000657
(gSOS)
 PSS000946|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.68, 0.83] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001873 PGS000657
(gSOS)
 PSS000938|
East Asian Ancestry|
25,034 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.79 [0.71, 0.88] — — Age, sex Only 13,848 of the original 21717 SNPs (63.8%) were used due to difference in reference panel.
PPM001874 PGS000657
(gSOS)
 PSS000938|
East Asian Ancestry|
25,034 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.74, 0.92] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis Only 13,848 of the original 21717 SNPs (63.8%) were used due to difference in reference panel.
PPM001875 PGS000657
(gSOS)
 PSS000947|
European Ancestry|
80,014 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.73 [0.63, 0.84] AUROC: 0.739 [0.724, 0.754] — Age, sex —
PPM001876 PGS000657
(gSOS)
 PSS000947|
European Ancestry|
80,014 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.75 [0.65, 0.86] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001877 PGS000657
(gSOS)
 PSS000941|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.73 [0.64, 0.83] — — Age, sex —
PPM001878 PGS000657
(gSOS)
 PSS000941|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.75 [0.65, 0.87] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001879 PGS000657
(gSOS)
 PSS000939|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.63, 0.93] — — Age, sex —
PPM001880 PGS000657
(gSOS)
 PSS000939|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.74 [0.58, 0.95] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001881 PGS000657
(gSOS)
 PSS000945|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.7, 0.84] — — Age, sex —
PPM001882 PGS000657
(gSOS)
 PSS000945|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.68, 0.84] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM001883 PGS000657
(gSOS)
 PSS000949|
European Ancestry|
4,717 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.71 [0.59, 0.85] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001884 PGS000657
(gSOS)
 PSS000942|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.74 [0.67, 0.81] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001885 PGS000657
(gSOS)
 PSS000940|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.72 [0.63, 0.81] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001886 PGS000657
(gSOS)
 PSS000946|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.77 [0.7, 0.84] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001887 PGS000657
(gSOS)
 PSS000941|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.74 [0.65, 0.83] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001888 PGS000657
(gSOS)
 PSS000939|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.8 [0.67, 0.96] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001889 PGS000657
(gSOS)
 PSS000945|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.69, 0.84] — — Clinical risk factor-based score (FRAX-CRF) —
PPM001890 PGS000657
(gSOS)
 PSS000949|
European Ancestry|
4,717 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.63, 0.9] — — Age, sex, measured femoral neck bone mineral density —
PPM001891 PGS000657
(gSOS)
 PSS000942|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.9] — — Age, sex, measured femoral neck bone mineral density —
PPM001892 PGS000657
(gSOS)
 PSS000940|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.78 [0.68, 0.88] — — Age, sex, measured femoral neck bone mineral density —
PPM001893 PGS000657
(gSOS)
 PSS000946|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.9] — — Age, sex, measured femoral neck bone mineral density —
PPM001894 PGS000657
(gSOS)
 PSS000941|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.85 [0.75, 0.97] — — Age, sex, measured femoral neck bone mineral density —
PPM001895 PGS000657
(gSOS)
 PSS000945|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.83 [0.76, 0.93] — — Age, sex, measured femoral neck bone mineral density —
PPM001896 PGS000657
(gSOS)
 PSS000949|
European Ancestry|
4,717 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.63, 0.89] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001897 PGS000657
(gSOS)
 PSS000942|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.78 [0.71, 0.85] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001898 PGS000657
(gSOS)
 PSS000940|
European Ancestry|
1,880 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.75 [0.66, 0.85] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001899 PGS000657
(gSOS)
 PSS000946|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.82 [0.75, 0.89] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001900 PGS000657
(gSOS)
 PSS000941|
European Ancestry|
4,663 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.76 [0.68, 0.87] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001901 PGS000657
(gSOS)
 PSS000945|
European Ancestry|
3,615 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture OR: 0.8 [0.73, 0.88] — — Clinical risk factor-based score including bone mineral density (FRAX-BMD) —
PPM001902 PGS000657
(gSOS)
 PSS000944|
European Ancestry|
8,278 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture — C-index: 0.66 [0.641, 0.679] — Clinical risk factor-based score (FRAX-CRF) —
PPM001903 PGS000657
(gSOS)
 PSS000943|
European Ancestry|
8,278 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident hip fracture — C-index: 0.682 [0.66, 0.704] — Clinical risk factor-based score (FRAX-CRF) —
PPM001851 PGS000657
(gSOS)
 PSS000937|
European Ancestry|
80,014 individuals
 PGP000153 |
Manousaki D et al. J Bone Miner Res (2020)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.7 [0.66, 0.75] — Odds Ratio (OR, bottom 50% vs top 50%): 1.79 [1.58, 2.01] Basline fracture risk (FRAX), fracture-related drug use —
PPM001866 PGS000657
(gSOS)
 PSS000948|
European Ancestry|
80,014 individuals
 PGP000154 |
Lu T et al. Genome Med (2021)
|Ext.		 Reported Trait: Incident major osteoporotic fracture OR: 0.7 [0.66, 0.75] — — Age, sex, body mass index, prior fracture, smoking, corticosteroids use, rheumatoid arthritis, parental fracture, at-risk drinking, falls at baseline, secondary osteoperosis —
PPM007579 PGS000951
(GBE_INI3144)
 PSS007226|
African Ancestry|
2,252 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — R²: 0.03865 [0.02946, 0.04783]
Incremental R2 (full-covars): 0.01472
PGS R2 (no covariates): 0.01564 [0.00966, 0.02163]		 age, sex, UKB array type, Genotype PCs —
PPM007580 PGS000951
(GBE_INI3144)
 PSS007227|
East Asian Ancestry|
795 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — R²: 0.09355 [0.06728, 0.11982]
Incremental R2 (full-covars): 0.05152
PGS R2 (no covariates): 0.05375 [0.03296, 0.07454]		 age, sex, UKB array type, Genotype PCs —
PPM007581 PGS000951
(GBE_INI3144)
 PSS007228|
European Ancestry|
12,376 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — R²: 0.1963 [0.18746, 0.20514]
Incremental R2 (full-covars): 0.11678
PGS R2 (no covariates): 0.11778 [0.11026, 0.1253]		 age, sex, UKB array type, Genotype PCs —
PPM007582 PGS000951
(GBE_INI3144)
 PSS007229|
South Asian Ancestry|
2,312 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — R²: 0.09722 [0.08476, 0.10969]
Incremental R2 (full-covars): 0.05231
PGS R2 (no covariates): 0.05582 [0.04594, 0.06569]		 age, sex, UKB array type, Genotype PCs —
PPM007583 PGS000951
(GBE_INI3144)
 PSS007230|
European Ancestry|
38,830 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — R²: 0.20634 [0.2009, 0.21179]
Incremental R2 (full-covars): 0.11895
PGS R2 (no covariates): 0.11837 [0.11379, 0.12295]		 age, sex, UKB array type, Genotype PCs —
PPM007584 PGS000952
(GBE_INI3147)
 PSS007236|
African Ancestry|
2,253 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry — — R²: 0.03462 [0.02589, 0.04335]
Incremental R2 (full-covars): 0.01756
PGS R2 (no covariates): 0.01829 [0.01183, 0.02474]		 age, sex, UKB array type, Genotype PCs —
PPM007585 PGS000952
(GBE_INI3147)
 PSS007237|
East Asian Ancestry|
795 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry — — R²: 0.09836 [0.07157, 0.12516]
Incremental R2 (full-covars): 0.06627
PGS R2 (no covariates): 0.06933 [0.04611, 0.09255]		 age, sex, UKB array type, Genotype PCs —
PPM007586 PGS000952
(GBE_INI3147)
 PSS007238|
European Ancestry|
12,376 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry — — R²: 0.18809 [0.17935, 0.19684]
Incremental R2 (full-covars): 0.13505
PGS R2 (no covariates): 0.13677 [0.12885, 0.1447]		 age, sex, UKB array type, Genotype PCs —
PPM007587 PGS000952
(GBE_INI3147)
 PSS007239|
South Asian Ancestry|
2,312 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry — — R²: 0.10193 [0.08923, 0.11462]
Incremental R2 (full-covars): 0.06757
PGS R2 (no covariates): 0.07119 [0.06022, 0.08216]		 age, sex, UKB array type, Genotype PCs —
PPM007588 PGS000952
(GBE_INI3147)
 PSS007240|
European Ancestry|
38,834 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry — — R²: 0.1966 [0.19122, 0.20198]
Incremental R2 (full-covars): 0.1419
PGS R2 (no covariates): 0.14158 [0.13671, 0.14646]		 age, sex, UKB array type, Genotype PCs —
PPM007591 PGS000953
(GBE_INI4101)
 PSS007278|
European Ancestry|
10,636 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel broadband ultrasound attenuation (L) — — R²: 0.18344 [0.17475, 0.19212]
Incremental R2 (full-covars): 0.09737
PGS R2 (no covariates): 0.09704 [0.09006, 0.10403]		 age, sex, UKB array type, Genotype PCs —
PPM007589 PGS000953
(GBE_INI4101)
 PSS007276|
African Ancestry|
3,559 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel broadband ultrasound attenuation (L) — — R²: 0.03758 [0.02851, 0.04665]
Incremental R2 (full-covars): 0.00859
PGS R2 (no covariates): 0.00936 [0.0047, 0.01402]		 age, sex, UKB array type, Genotype PCs —
PPM007590 PGS000953
(GBE_INI4101)
 PSS007277|
East Asian Ancestry|
781 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel broadband ultrasound attenuation (L) — — Incremental R2 (full-covars): 0.07295
R²: 0.10345 [0.07612, 0.13077]
PGS R2 (no covariates): 0.07189 [0.0483, 0.09547]		 age, sex, UKB array type, Genotype PCs —
PPM007592 PGS000953
(GBE_INI4101)
 PSS007279|
South Asian Ancestry|
5,043 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel broadband ultrasound attenuation (L) — — R²: 0.08632 [0.07443, 0.0982]
Incremental R2 (full-covars): 0.04895
PGS R2 (no covariates): 0.04892 [0.03961, 0.05823]		 age, sex, UKB array type, Genotype PCs —
PPM007593 PGS000953
(GBE_INI4101)
 PSS007280|
European Ancestry|
25,716 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel broadband ultrasound attenuation (L) — — R²: 0.19239 [0.18705, 0.19774]
Incremental R2 (full-covars): 0.09654
PGS R2 (no covariates): 0.09575 [0.09152, 0.09997]		 age, sex, UKB array type, Genotype PCs —
PPM007594 PGS000954
(GBE_INI4104)
 PSS007286|
African Ancestry|
3,560 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (L) — — R²: 0.02571 [0.01811, 0.0333]
Incremental R2 (full-covars): 0.00528
PGS R2 (no covariates): 0.00688 [0.00288, 0.01088]		 age, sex, UKB array type, Genotype PCs —
PPM007595 PGS000954
(GBE_INI4104)
 PSS007287|
East Asian Ancestry|
781 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (L) — — R²: 0.10298 [0.0757, 0.13026]
Incremental R2 (full-covars): 0.08296
PGS R2 (no covariates): 0.082 [0.05708, 0.10691]		 age, sex, UKB array type, Genotype PCs —
PPM007596 PGS000954
(GBE_INI4104)
 PSS007288|
European Ancestry|
10,636 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (L) — — R²: 0.17491 [0.16634, 0.18348]
Incremental R2 (full-covars): 0.11202
PGS R2 (no covariates): 0.11274 [0.10534, 0.12014]		 age, sex, UKB array type, Genotype PCs —
PPM007597 PGS000954
(GBE_INI4104)
 PSS007289|
South Asian Ancestry|
5,043 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (L) — — R²: 0.08121 [0.06962, 0.0928]
Incremental R2 (full-covars): 0.05294
PGS R2 (no covariates): 0.05414 [0.0444, 0.06389]		 age, sex, UKB array type, Genotype PCs —
PPM007598 PGS000954
(GBE_INI4104)
 PSS007290|
European Ancestry|
25,716 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (L) — — R²: 0.17984 [0.17459, 0.18509]
Incremental R2 (full-covars): 0.11708
PGS R2 (no covariates): 0.11589 [0.11135, 0.12043]		 age, sex, UKB array type, Genotype PCs —
PPM007599 PGS000955
(GBE_INI4120)
 PSS007306|
African Ancestry|
3,591 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel broadband ultrasound attenuation (R) — — R²: 0.03102 [0.02273, 0.03932]
Incremental R2 (full-covars): 0.0053
PGS R2 (no covariates): 0.00612 [0.00234, 0.0099]		 age, sex, UKB array type, Genotype PCs —
PPM007600 PGS000955
(GBE_INI4120)
 PSS007307|
East Asian Ancestry|
782 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel broadband ultrasound attenuation (R) — — R²: 0.1074 [0.07968, 0.13512]
Incremental R2 (full-covars): 0.06527
PGS R2 (no covariates): 0.06337 [0.04102, 0.08571]		 age, sex, UKB array type, Genotype PCs —
PPM007601 PGS000955
(GBE_INI4120)
 PSS007308|
European Ancestry|
10,633 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel broadband ultrasound attenuation (R) — — R²: 0.18118 [0.17253, 0.18984]
Incremental R2 (full-covars): 0.09282
PGS R2 (no covariates): 0.09341 [0.08653, 0.10029]		 age, sex, UKB array type, Genotype PCs —
PPM007602 PGS000955
(GBE_INI4120)
 PSS007309|
South Asian Ancestry|
5,040 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel broadband ultrasound attenuation (R) — — R²: 0.08322 [0.07151, 0.09493]
Incremental R2 (full-covars): 0.05145
PGS R2 (no covariates): 0.05095 [0.04147, 0.06044]		 age, sex, UKB array type, Genotype PCs —
PPM007603 PGS000955
(GBE_INI4120)
 PSS007310|
European Ancestry|
25,727 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel broadband ultrasound attenuation (R) — — R²: 0.20708 [0.20164, 0.21253]
Incremental R2 (full-covars): 0.10115
PGS R2 (no covariates): 0.10011 [0.09582, 0.10441]		 age, sex, UKB array type, Genotype PCs —
PPM007604 PGS000956
(GBE_INI4123)
 PSS007316|
African Ancestry|
3,592 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (R) — — R²: 0.02463 [0.01719, 0.03208]
Incremental R2 (full-covars): 0.00617
PGS R2 (no covariates): 0.00698 [0.00295, 0.01101]		 age, sex, UKB array type, Genotype PCs —
PPM007605 PGS000956
(GBE_INI4123)
 PSS007317|
East Asian Ancestry|
782 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (R) — — R²: 0.09886 [0.07201, 0.12571]
Incremental R2 (full-covars): 0.07542
PGS R2 (no covariates): 0.07555 [0.05147, 0.09963]		 age, sex, UKB array type, Genotype PCs —
PPM007606 PGS000956
(GBE_INI4123)
 PSS007318|
European Ancestry|
10,633 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (R) — — R²: 0.17521 [0.16663, 0.18378]
Incremental R2 (full-covars): 0.11145
PGS R2 (no covariates): 0.11271 [0.10531, 0.12011]		 age, sex, UKB array type, Genotype PCs —
PPM007607 PGS000956
(GBE_INI4123)
 PSS007319|
South Asian Ancestry|
5,041 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (R) — — R²: 0.08263 [0.07095, 0.0943]
Incremental R2 (full-covars): 0.05817
PGS R2 (no covariates): 0.05816 [0.0481, 0.06821]		 age, sex, UKB array type, Genotype PCs —
PPM007608 PGS000956
(GBE_INI4123)
 PSS007320|
European Ancestry|
25,728 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (R) — — R²: 0.19359 [0.18823, 0.19894]
Incremental R2 (full-covars): 0.1242
PGS R2 (no covariates): 0.12266 [0.11802, 0.1273]		 age, sex, UKB array type, Genotype PCs —
PPM007075 PGS001529
(GBE_INI3146)
 PSS007231|
African Ancestry|
1,434 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel — — R²: 0.03275 [0.02202, 0.04347]
Incremental R2 (full-covars): 0.0181
PGS R2 (no covariates): 0.01912 [0.01081, 0.02743]		 age, sex, UKB array type, Genotype PCs —
PPM007076 PGS001529
(GBE_INI3146)
 PSS007232|
East Asian Ancestry|
500 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel — — R²: 0.10987 [0.07399, 0.14575]
Incremental R2 (full-covars): 0.07069
PGS R2 (no covariates): 0.08324 [0.05108, 0.11541]		 age, sex, UKB array type, Genotype PCs —
PPM007077 PGS001529
(GBE_INI3146)
 PSS007233|
European Ancestry|
7,691 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel — — R²: 0.17225 [0.16143, 0.18307]
Incremental R2 (full-covars): 0.13354
PGS R2 (no covariates): 0.13618 [0.12614, 0.14622]		 age, sex, UKB array type, Genotype PCs —
PPM007078 PGS001529
(GBE_INI3146)
 PSS007234|
South Asian Ancestry|
1,449 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel — — R²: 0.11013 [0.09349, 0.12678]
Incremental R2 (full-covars): 0.08026
PGS R2 (no covariates): 0.08576 [0.07067, 0.10085]		 age, sex, UKB array type, Genotype PCs —
PPM007079 PGS001529
(GBE_INI3146)
 PSS007235|
European Ancestry|
24,146 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel — — R²: 0.18117 [0.17451, 0.18783]
Incremental R2 (full-covars): 0.13986
PGS R2 (no covariates): 0.14001 [0.13386, 0.14616]		 age, sex, UKB array type, Genotype PCs —
PPM007095 PGS001530
(GBE_INI4103)
 PSS007281|
African Ancestry|
3,560 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (L) — — R²: 0.02043 [0.01363, 0.02724]
Incremental R2 (full-covars): 0.00372
PGS R2 (no covariates): 0.00552 [0.00193, 0.00911]		 age, sex, UKB array type, Genotype PCs —
PPM007096 PGS001530
(GBE_INI4103)
 PSS007282|
East Asian Ancestry|
781 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (L) — — R²: 0.1024 [0.07518, 0.12962]
Incremental R2 (full-covars): 0.0813
PGS R2 (no covariates): 0.08045 [0.05573, 0.10516]		 age, sex, UKB array type, Genotype PCs —
PPM007097 PGS001530
(GBE_INI4103)
 PSS007283|
European Ancestry|
10,636 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (L) — — R²: 0.16053 [0.15218, 0.16889]
Incremental R2 (full-covars): 0.10916
PGS R2 (no covariates): 0.11118 [0.10382, 0.11854]		 age, sex, UKB array type, Genotype PCs —
PPM007098 PGS001530
(GBE_INI4103)
 PSS007284|
South Asian Ancestry|
5,043 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (L) — — R²: 0.07631 [0.06501, 0.0876]
Incremental R2 (full-covars): 0.05214
PGS R2 (no covariates): 0.05376 [0.04404, 0.06347]		 age, sex, UKB array type, Genotype PCs —
PPM007099 PGS001530
(GBE_INI4103)
 PSS007285|
European Ancestry|
25,716 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (L) — — R²: 0.16377 [0.15866, 0.16887]
Incremental R2 (full-covars): 0.11885
PGS R2 (no covariates): 0.118 [0.11343, 0.12257]		 age, sex, UKB array type, Genotype PCs —
PPM007105 PGS001531
(GBE_INI4122)
 PSS007311|
African Ancestry|
3,592 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (R) — — R²: 0.02141 [0.01445, 0.02837]
Incremental R2 (full-covars): 0.0063
PGS R2 (no covariates): 0.00698 [0.00295, 0.01101]		 age, sex, UKB array type, Genotype PCs —
PPM007106 PGS001531
(GBE_INI4122)
 PSS007312|
East Asian Ancestry|
782 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (R) — — R²: 0.09852 [0.07171, 0.12534]
Incremental R2 (full-covars): 0.07672
PGS R2 (no covariates): 0.07776 [0.05339, 0.10214]		 age, sex, UKB array type, Genotype PCs —
PPM007107 PGS001531
(GBE_INI4122)
 PSS007313|
European Ancestry|
10,633 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (R) — — R²: 0.16134 [0.15298, 0.16971]
Incremental R2 (full-covars): 0.10988
PGS R2 (no covariates): 0.11176 [0.10439, 0.11914]		 age, sex, UKB array type, Genotype PCs —
PPM007108 PGS001531
(GBE_INI4122)
 PSS007314|
South Asian Ancestry|
5,041 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (R) — — R²: 0.07785 [0.06646, 0.08924]
Incremental R2 (full-covars): 0.05682
PGS R2 (no covariates): 0.05742 [0.04742, 0.06742]		 age, sex, UKB array type, Genotype PCs —
PPM007109 PGS001531
(GBE_INI4122)
 PSS007315|
European Ancestry|
25,728 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Speed of sound through heel (R) — — R²: 0.17507 [0.16986, 0.18028]
Incremental R2 (full-covars): 0.12574
PGS R2 (no covariates): 0.12479 [0.12013, 0.12946]		 age, sex, UKB array type, Genotype PCs —
PPM010523 PGS001956
(portability-PLR_log_heel_BUA)
 PSS009447|
European Ancestry|
11,485 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.4264 [0.4113, 0.4413] sex, age, birth date, deprivation index, 16 PCs —
PPM010524 PGS001956
(portability-PLR_log_heel_BUA)
 PSS009221|
European Ancestry|
2,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.4076 [0.3715, 0.4424] sex, age, birth date, deprivation index, 16 PCs —
PPM010525 PGS001956
(portability-PLR_log_heel_BUA)
 PSS008775|
European Ancestry|
3,463 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3665 [0.3372, 0.395] sex, age, birth date, deprivation index, 16 PCs —
PPM010526 PGS001956
(portability-PLR_log_heel_BUA)
 PSS008549|
Greater Middle Eastern Ancestry|
505 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.306 [0.223, 0.3845] sex, age, birth date, deprivation index, 16 PCs —
PPM010527 PGS001956
(portability-PLR_log_heel_BUA)
 PSS008327|
South Asian Ancestry|
1,968 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3216 [0.2812, 0.3609] sex, age, birth date, deprivation index, 16 PCs —
PPM010528 PGS001956
(portability-PLR_log_heel_BUA)
 PSS008104|
East Asian Ancestry|
819 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.2762 [0.2109, 0.3391] sex, age, birth date, deprivation index, 16 PCs —
PPM010529 PGS001956
(portability-PLR_log_heel_BUA)
 PSS007891|
African Ancestry|
795 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.1457 [0.076, 0.2139] sex, age, birth date, deprivation index, 16 PCs —
PPM010530 PGS001956
(portability-PLR_log_heel_BUA)
 PSS008995|
African Ancestry|
1,404 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.1465 [0.0946, 0.1977] sex, age, birth date, deprivation index, 16 PCs —
PPM012240 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS009221|
European Ancestry|
2,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3925 [0.3559, 0.4278] sex, age, birth date, deprivation index, 16 PCs —
PPM012241 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS008775|
European Ancestry|
3,463 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3599 [0.3305, 0.3887] sex, age, birth date, deprivation index, 16 PCs —
PPM012242 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS008549|
Greater Middle Eastern Ancestry|
505 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3282 [0.2463, 0.4054] sex, age, birth date, deprivation index, 16 PCs —
PPM012243 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS008327|
South Asian Ancestry|
1,968 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.3051 [0.2643, 0.3449] sex, age, birth date, deprivation index, 16 PCs —
PPM012244 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS008104|
East Asian Ancestry|
819 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.2633 [0.1976, 0.3267] sex, age, birth date, deprivation index, 16 PCs —
PPM012245 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS007891|
African Ancestry|
795 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.1219 [0.0519, 0.1907] sex, age, birth date, deprivation index, 16 PCs —
PPM012246 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS008995|
African Ancestry|
1,404 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.1515 [0.0996, 0.2026] sex, age, birth date, deprivation index, 16 PCs —
PPM012239 PGS002174
(portability-ldpred2_log_heel_BUA)
 PSS009447|
European Ancestry|
11,485 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — Partial Correlation (partial-r): 0.4168 [0.4015, 0.4318] sex, age, birth date, deprivation index, 16 PCs —
PPM017464 PGS003536
(cont-decay-log_heel_BUA)
 PSS010900|
European Ancestry|
11,353 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — partial-R2: 0.17 sex, age, deprivation index, PC1-16 —
PPM017548 PGS003536
(cont-decay-log_heel_BUA)
 PSS010816|
European Ancestry|
2,146 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — partial-R2: 0.17 sex, age, deprivation index, PC1-16 —
PPM017632 PGS003536
(cont-decay-log_heel_BUA)
 PSS010648|
European Ancestry|
3,386 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — partial-R2: 0.13 sex, age, deprivation index, PC1-16 —
PPM017716 PGS003536
(cont-decay-log_heel_BUA)
 PSS010564|
Greater Middle Eastern Ancestry|
486 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — partial-R2: 0.1 sex, age, deprivation index, PC1-16 —
PPM017968 PGS003536
(cont-decay-log_heel_BUA)
 PSS010396|
East Asian Ancestry|
810 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — partial-R2: 0.07 sex, age, deprivation index, PC1-16 —
PPM018136 PGS003536
(cont-decay-log_heel_BUA)
 PSS010732|
African Ancestry|
1,395 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM017800 PGS003536
(cont-decay-log_heel_BUA)
 PSS010228|
European Ancestry|
1,382 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — partial-R2: 0.14 sex, age, deprivation index, PC1-16 —
PPM017884 PGS003536
(cont-decay-log_heel_BUA)
 PSS010480|
South Asian Ancestry|
1,961 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — partial-R2: 0.09 sex, age, deprivation index, PC1-16 —
PPM018052 PGS003536
(cont-decay-log_heel_BUA)
 PSS010312|
African Ancestry|
791 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM020528 PGS004413
(X3144.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel Broadband ultrasound attenuation, direct entry — — PGS R2 (no covariates): 0.27085 — —
PPM020529 PGS004414
(X3147.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry — — PGS R2 (no covariates): 0.30125 — —
PPM020532 PGS004417
(X4101.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel broadband ultrasound attenuation (left) — — PGS R2 (no covariates): 0.21942 — —
PPM020533 PGS004418
(X4104.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (left) — — PGS R2 (no covariates): 0.24743 — —
PPM020537 PGS004422
(X4120.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel broadband ultrasound attenuation (right) — — PGS R2 (no covariates): 0.22006 — —
PPM020538 PGS004423
(X4123.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Heel quantitative ultrasound index (QUI), direct entry (right) — — PGS R2 (no covariates): 0.24814 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007228 — — 12,376 individuals — European non-white British ancestry UKB —
PSS007229 — — 2,312 individuals — South Asian — UKB —
PSS007230 — — 38,830 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007231 — — 1,434 individuals — African unspecified — UKB —
PSS007232 — — 500 individuals — East Asian — UKB —
PSS007233 — — 7,691 individuals — European non-white British ancestry UKB —
PSS007234 — — 1,449 individuals — South Asian — UKB —
PSS007235 — — 24,146 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007236 — — 2,253 individuals — African unspecified — UKB —
PSS007237 — — 795 individuals — East Asian — UKB —
PSS007238 — — 12,376 individuals — European non-white British ancestry UKB —
PSS007239 — — 2,312 individuals — South Asian — UKB —
PSS007240 — — 38,834 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007276 — — 3,559 individuals — African unspecified — UKB —
PSS007277 — — 781 individuals — East Asian — UKB —
PSS007278 — — 10,636 individuals — European non-white British ancestry UKB —
PSS007279 — — 5,043 individuals — South Asian — UKB —
PSS007280 — — 25,716 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007281 — — 3,560 individuals — African unspecified — UKB —
PSS007282 — — 781 individuals — East Asian — UKB —
PSS007283 — — 10,636 individuals — European non-white British ancestry UKB —
PSS007284 — — 5,043 individuals — South Asian — UKB —
PSS007285 — — 25,716 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007286 — — 3,560 individuals — African unspecified — UKB —
PSS007287 — — 781 individuals — East Asian — UKB —
PSS007288 — — 10,636 individuals — European non-white British ancestry UKB —
PSS007289 — — 5,043 individuals — South Asian — UKB —
PSS007290 — — 25,716 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS009221 — — 2,147 individuals — European Poland (NE Europe) UKB —
PSS007306 — — 3,591 individuals — African unspecified — UKB —
PSS007307 — — 782 individuals — East Asian — UKB —
PSS007308 — — 10,633 individuals — European non-white British ancestry UKB —
PSS007309 — — 5,040 individuals — South Asian — UKB —
PSS007310 — — 25,727 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007311 — — 3,592 individuals — African unspecified — UKB —
PSS007312 — — 782 individuals — East Asian — UKB —
PSS007313 — — 10,633 individuals — European non-white British ancestry UKB —
PSS007314 — — 5,041 individuals — South Asian — UKB —
PSS007315 — — 25,728 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007316 — — 3,592 individuals — African unspecified — UKB —
PSS007317 — — 782 individuals — East Asian — UKB —
PSS007318 — — 10,633 individuals — European non-white British ancestry UKB —
PSS007319 — — 5,041 individuals — South Asian — UKB —
PSS007320 — — 25,728 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS010228 — — 1,382 individuals,
47.0 % Male samples
 Mean = 57.7 years
Sd = 7.1 years		 European Ashkenazi UKB —
PSS008775 — — 3,463 individuals — European Italy (South Europe) UKB —
PSS010816 — — 2,146 individuals,
39.0 % Male samples
 Mean = 54.3 years
Sd = 7.2 years		 European Polish UKB —
PSS010312 — — 791 individuals,
35.0 % Male samples
 Mean = 52.2 years
Sd = 8.2 years		 African American or Afro-Caribbean Caribbean UKB —
PSS008327 — — 1,968 individuals — South Asian India (South Asia) UKB —
PSS010900 — — 11,353 individuals,
46.0 % Male samples
 Mean = 56.8 years
Sd = 7.8 years		 European white British UKB —
PSS010396 — — 810 individuals,
35.0 % Male samples
 Mean = 51.9 years
Sd = 7.5 years		 East Asian Chinese UKB —
PSS007891 — — 795 individuals — African American or Afro-Caribbean Carribean UKB —
PSS000585 — — 4,741 individuals,
47.5 % Male samples
 Mean = 55.8 years
Sd = 7.6 years		 European — UKB —
PSS000585 — — 6,704 individuals,
49.3 % Male samples
 Mean = 62.6 years
Sd = 9.9 years		 European, NR — CLSA —
PSS000585 — — 3,426 individuals,
0.0 % Male samples
 Mean = 71.5 years
Sd = 5.3 years		 European, NR — SOF —
PSS000585 — — 4,657 individuals,
100.0 % Male samples
 Mean = 74.0 years
Sd = 6.0 years		 European — MrOS-USA —
PSS000585 — — 1,880 individuals,
100.0 % Male samples
 Mean = 75.4 years
Sd = 3.2 years		 European
(Swedish)		 — MrOS-SWE —
PSS000586 — — 80,027 individuals,
47.5 % Male samples
 Mean = 55.8 years
Sd = 7.6 years		 European — UKB —
PSS009447 — — 11,485 individuals — European UK (+ Ireland) UKB —
PSS010480 — — 1,961 individuals,
56.0 % Male samples
 Mean = 52.7 years
Sd = 8.2 years		 South Asian Indian UKB —
PSS011364 — — 56,192 individuals — European — UKB —
PSS008995 — — 1,404 individuals — African unspecified Nigeria (West Africa) UKB —
PSS000932 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 68 cases
  • , 12,610 controls
]
,
40.52 % Male samples
 Mean = 58.6 years
Sd = 7.7 years		 European — UKB —
PSS000933 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 256 cases
  • , 12,422 controls
]
,
40.52 % Male samples
 Mean = 58.6 years
Sd = 7.6 years		 European — UKB —
PSS000934 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S322 —
[
  • 141 cases
  • , 67,195 controls
]
,
46.27 % Male samples
 Mean = 56.5 years
Sd = 8.2 years		 European — UKB —
PSS000935 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S321 —
[
  • 933 cases
  • , 66,403 controls
]
,
46.27 % Male samples
 Mean = 56.5 years
Sd = 8.1 years		 European — UKB —
PSS000936 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 209 cases
  • , 79,805 controls
]
,
45.36 % Male samples
 Mean = 56.8 years
Sd = 8.1 years		 European — UKB —
PSS000937 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320 —
[
  • 1,189 cases
  • , 78,825 controls
]
,
45.36 % Male samples
 Mean = 56.8 years
Sd = 8.0 years		 European — UKB —
PSS000938 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. —
[
  • 323 cases
  • , 24,711 controls
]
,
42.7 % Male samples
 Mean = 53.7 years
Sd = 11.0 years		 East Asian — CKB —
PSS000939 Cases included individuals with a hip fracture that occurred after the baseline visit. —
[
  • 129 cases
  • , 1,751 controls
]
,
100.0 % Male samples
 Mean = 75.4 years
Sd = 3.2 years		 European — MrOS-SWE —
PSS000940 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. —
[
  • 337 cases
  • , 1,543 controls
]
,
100.0 % Male samples
 Mean = 75.4 years
Sd = 3.2 years		 European — MrOS-SWE —
PSS000941 Cases included individuals with a hip fracture that occurred after the baseline visit. Mean = 4.5 years
[
  • 273 cases
  • , 4,390 controls
]
,
100.0 % Male samples
 Mean = 74.0 years
Sd = 6.0 years		 European — MrOS-USA —
PSS000942 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Mean = 4.5 years
[
  • 560 cases
  • , 4,103 controls
]
,
100.0 % Male samples
 Mean = 74.0 years
Sd = 6.0 years		 European — MrOS-USA —
PSS000943 Cases included individuals with a hip fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 829 cases
  • , 7,449 controls
]
,
56.33 % Male samples
 — European — MrOS-USA, SOF —
PSS000944 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 1,267 cases
  • , 7,011 controls
]
,
56.33 % Male samples
 — European — MrOS-USA, SOF —
PSS000945 Cases included individuals with a hip fracture that occurred after the baseline visit. Mean = 14.5 years
[
  • 556 cases
  • , 3,059 controls
]
,
0.0 % Male samples
 Mean = 71.5 years
Sd = 5.3 years		 European — SOF —
PSS000946 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. Mean = 14.5 years
[
  • 707 cases
  • , 2,908 controls
]
,
0.0 % Male samples
 Mean = 71.5 years
Sd = 5.3 years		 European — SOF —
PSS000947 Cases included individuals with a hip fracture that occurred after the baseline visit. —
[
  • 209 cases
  • , 79,805 controls
]
,
45.36 % Male samples
 Mean = 56.8 years
Sd = 8.0 years		 European — UKB —
PSS000948 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. ICD 10 codes include: M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722. —
[
  • 1,189 cases
  • , 78,825 controls
]
,
45.36 % Male samples
 Mean = 56.8 years
Sd = 8.0 years		 European — UKB —
PSS000949 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. ICD 10 codes include: M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722. —
[
  • 125 cases
  • , 4,592 controls
]
 — European — UKB —
PSS000950 Cases included individuals with a hip fracture that occurred after the baseline visit. Range = [4.5, 14.5] years
[
  • 1,167 cases
  • , 89,005 controls
]
,
31.61 % Male samples
 — European — MrOS-SWE, MrOS-USA, SOF, UKB —
PSS000951 Cases included individuals with a major osteoporotic fracture that occurred after the baseline visit. UKB cohort: Sitespecific major osteoporotic fractures were defined basedon ICD10 codes of primary diagnoses (M8002, M8003, M8005, M8008, M8082, M8083, M8085, M8088, S220, S320, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, S720, S721, and S722) and self-reported medical history. Range = [4.5, 14.5] years
[
  • 2,793 cases
  • , 87,379 controls
]
,
31.61 % Male samples
 — European — MrOS-SWE, MrOS-USA, SOF, UKB —
PSS010732 — — 1,395 individuals,
49.0 % Male samples
 Mean = 52.0 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS008549 — — 505 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS010564 — — 486 individuals,
65.0 % Male samples
 Mean = 51.1 years
Sd = 7.6 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS008104 — — 819 individuals — East Asian China (East Asia) UKB —
PSS010648 — — 3,386 individuals,
46.0 % Male samples
 Mean = 54.5 years
Sd = 8.2 years		 European Italian UKB —
PSS007226 — — 2,252 individuals — African unspecified — UKB —
PSS007227 — — 795 individuals — East Asian — UKB —