Trait: creatinine measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004518
Description A creatinine measurement is a measure of the metabolite creatinine in a sample. For example, in the serum, where it can be used in assessment of kidney function.
Trait category
Other measurement
Synonyms 3 synonyms
  • creatinine levels
  • serum creatinine levels
  • serum creatinine measurement
Mapped term NCIt:C61023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000678
(snpnet.Creatinine)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Creatinine [umol/L] creatinine measurement 21,027
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000678/ScoringFiles/PGS000678.txt.gz - Check Terms/Licenses
PGS001945
(portability-PLR_log_creatinine)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Creatinine creatinine measurement 76,800
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001945/ScoringFiles/PGS001945.txt.gz
PGS002163
(portability-ldpred2_log_creatinine)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Creatinine creatinine measurement 835,964
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002163/ScoringFiles/PGS002163.txt.gz
PGS003526
(cont-decay-log_creatinine)
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Creatinine creatinine measurement 979,739
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003526/ScoringFiles/PGS003526.txt.gz
PGS004334
(X30700.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Creatinine (umol/L) creatinine measurement 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004334/ScoringFiles/PGS004334.txt.gz
PGS004747
(creatinine_PRSmix_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Serum creatinine creatinine measurement 609,027
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004747/ScoringFiles/PGS004747.txt.gz
PGS004748
(creatinine_PRSmix_sas)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Serum creatinine creatinine measurement 2,653,053
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004748/ScoringFiles/PGS004748.txt.gz
PGS004749
(creatinine_PRSmixPlus_eur)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Serum creatinine creatinine measurement 1,469,062
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004749/ScoringFiles/PGS004749.txt.gz
PGS004750
(creatinine_PRSmixPlus_sas)
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Serum creatinine creatinine measurement 2,653,053
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004750/ScoringFiles/PGS004750.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001406 PGS000678
(snpnet.Creatinine)
 PSS000667|
African Ancestry|
6,016 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Creatinine [umol/L] — — R²: 0.37051
Spearman's ρ: 0.146		 Age, sex, PCs(1-40) —
PPM001441 PGS000678
(snpnet.Creatinine)
 PSS000668|
East Asian Ancestry|
1,081 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Creatinine [umol/L] — — R²: 0.44314
Spearman's ρ: 0.229		 Age, sex, PCs(1-40) —
PPM001476 PGS000678
(snpnet.Creatinine)
 PSS000674|
European Ancestry|
23,576 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Creatinine [umol/L] — — R²: 0.3939
Spearman's ρ: 0.325		 Age, sex, PCs(1-40) —
PPM001511 PGS000678
(snpnet.Creatinine)
 PSS000675|
South Asian Ancestry|
7,339 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Creatinine [umol/L] — — R²: 0.40587
Spearman's ρ: 0.283		 Age, sex, PCs(1-40) —
PPM001546 PGS000678
(snpnet.Creatinine)
 PSS000676|
European Ancestry|
63,758 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Creatinine [umol/L] — — R²: 0.41565
Spearman's ρ: 0.337		 Age, sex, PCs(1-40) —
PPM001579 PGS000678
(snpnet.Creatinine)
 PSS000800|
European Ancestry|
2,129 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Creatinine [umol/L] — — Spearman's ρ: 0.24 Age, sex —
PPM007315 PGS000678
(snpnet.Creatinine)
 PSS007131|
African Ancestry|
6,097 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Creatinine — — R²: 0.1805 [0.16358, 0.19743]
Incremental R2 (full-covars): 0.00023
PGS R2 (no covariates): 0.0048 [0.00145, 0.00815]		 age, sex, UKB array type, Genotype PCs —
PPM007316 PGS000678
(snpnet.Creatinine)
 PSS007132|
East Asian Ancestry|
1,615 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Creatinine — — R²: 0.30903 [0.27263, 0.34543]
Incremental R2 (full-covars): 0.0006
PGS R2 (no covariates): 0.01099 [0.00116, 0.02081]		 age, sex, UKB array type, Genotype PCs —
PPM007317 PGS000678
(snpnet.Creatinine)
 PSS007133|
European Ancestry|
23,762 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Creatinine — — R²: 0.23065 [0.22147, 0.23982]
Incremental R2 (full-covars): 0.00126
PGS R2 (no covariates): 0.04345 [0.0385, 0.0484]		 age, sex, UKB array type, Genotype PCs —
PPM007318 PGS000678
(snpnet.Creatinine)
 PSS007134|
South Asian Ancestry|
7,427 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Creatinine — — R²: 0.2107 [0.19466, 0.22675]
Incremental R2 (full-covars): 0.00063
PGS R2 (no covariates): 0.02244 [0.01595, 0.02892]		 age, sex, UKB array type, Genotype PCs —
PPM007319 PGS000678
(snpnet.Creatinine)
 PSS007135|
European Ancestry|
64,433 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Creatinine — — R²: 0.23859 [0.23298, 0.24421]
Incremental R2 (full-covars): 0.00127
PGS R2 (no covariates): 0.04554 [0.04246, 0.04861]		 age, sex, UKB array type, Genotype PCs —
PPM010441 PGS001945
(portability-PLR_log_creatinine)
 PSS007883|
African Ancestry|
2,345 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.1379 [0.0978, 0.1776] sex, age, birth date, deprivation index, 16 PCs —
PPM010437 PGS001945
(portability-PLR_log_creatinine)
 PSS008767|
European Ancestry|
6,322 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.3344 [0.3123, 0.3562] sex, age, birth date, deprivation index, 16 PCs —
PPM010435 PGS001945
(portability-PLR_log_creatinine)
 PSS009439|
European Ancestry|
18,993 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.3568 [0.3443, 0.3691] sex, age, birth date, deprivation index, 16 PCs —
PPM010436 PGS001945
(portability-PLR_log_creatinine)
 PSS009213|
European Ancestry|
3,950 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.3499 [0.3221, 0.377] sex, age, birth date, deprivation index, 16 PCs —
PPM010438 PGS001945
(portability-PLR_log_creatinine)
 PSS008541|
Greater Middle Eastern Ancestry|
1,124 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.3425 [0.2894, 0.3936] sex, age, birth date, deprivation index, 16 PCs —
PPM010439 PGS001945
(portability-PLR_log_creatinine)
 PSS008319|
South Asian Ancestry|
6,003 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.2881 [0.2647, 0.3112] sex, age, birth date, deprivation index, 16 PCs —
PPM010440 PGS001945
(portability-PLR_log_creatinine)
 PSS008096|
East Asian Ancestry|
1,716 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.2465 [0.2013, 0.2907] sex, age, birth date, deprivation index, 16 PCs —
PPM010442 PGS001945
(portability-PLR_log_creatinine)
 PSS008987|
African Ancestry|
3,655 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.1382 [0.1062, 0.17] sex, age, birth date, deprivation index, 16 PCs —
PPM012151 PGS002163
(portability-ldpred2_log_creatinine)
 PSS009439|
European Ancestry|
18,993 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.353 [0.3405, 0.3654] sex, age, birth date, deprivation index, 16 PCs —
PPM012152 PGS002163
(portability-ldpred2_log_creatinine)
 PSS009213|
European Ancestry|
3,950 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.3476 [0.3198, 0.3748] sex, age, birth date, deprivation index, 16 PCs —
PPM012153 PGS002163
(portability-ldpred2_log_creatinine)
 PSS008767|
European Ancestry|
6,322 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.3305 [0.3083, 0.3523] sex, age, birth date, deprivation index, 16 PCs —
PPM012154 PGS002163
(portability-ldpred2_log_creatinine)
 PSS008541|
Greater Middle Eastern Ancestry|
1,124 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.3278 [0.2741, 0.3794] sex, age, birth date, deprivation index, 16 PCs —
PPM012157 PGS002163
(portability-ldpred2_log_creatinine)
 PSS007883|
African Ancestry|
2,345 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.1607 [0.1208, 0.2] sex, age, birth date, deprivation index, 16 PCs —
PPM012158 PGS002163
(portability-ldpred2_log_creatinine)
 PSS008987|
African Ancestry|
3,655 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.1261 [0.0939, 0.1579] sex, age, birth date, deprivation index, 16 PCs —
PPM012155 PGS002163
(portability-ldpred2_log_creatinine)
 PSS008319|
South Asian Ancestry|
6,003 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.2731 [0.2495, 0.2964] sex, age, birth date, deprivation index, 16 PCs —
PPM012156 PGS002163
(portability-ldpred2_log_creatinine)
 PSS008096|
East Asian Ancestry|
1,716 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Creatinine — — Partial Correlation (partial-r): 0.24 [0.1946, 0.2844] sex, age, birth date, deprivation index, 16 PCs —
PPM017454 PGS003526
(cont-decay-log_creatinine)
 PSS010889|
European Ancestry|
19,112 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Creatinine — — partial-R2: 0.12 sex, age, deprivation index, PC1-16 —
PPM017538 PGS003526
(cont-decay-log_creatinine)
 PSS010805|
European Ancestry|
3,939 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Creatinine — — partial-R2: 0.12 sex, age, deprivation index, PC1-16 —
PPM017622 PGS003526
(cont-decay-log_creatinine)
 PSS010637|
European Ancestry|
6,170 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Creatinine — — partial-R2: 0.11 sex, age, deprivation index, PC1-16 —
PPM017706 PGS003526
(cont-decay-log_creatinine)
 PSS010553|
Greater Middle Eastern Ancestry|
1,095 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Creatinine — — partial-R2: 0.11 sex, age, deprivation index, PC1-16 —
PPM017790 PGS003526
(cont-decay-log_creatinine)
 PSS010217|
European Ancestry|
2,235 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Creatinine — — partial-R2: 0.12 sex, age, deprivation index, PC1-16 —
PPM017874 PGS003526
(cont-decay-log_creatinine)
 PSS010469|
South Asian Ancestry|
5,949 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Creatinine — — partial-R2: 0.08 sex, age, deprivation index, PC1-16 —
PPM017958 PGS003526
(cont-decay-log_creatinine)
 PSS010385|
East Asian Ancestry|
1,705 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Creatinine — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —
PPM018042 PGS003526
(cont-decay-log_creatinine)
 PSS010301|
African Ancestry|
2,333 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Creatinine — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM018126 PGS003526
(cont-decay-log_creatinine)
 PSS010721|
African Ancestry|
3,626 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Creatinine — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM020449 PGS004334
(X30700.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: Creatinine (umol/L) — — PGS R2 (no covariates): 0.2141 — —
PPM020972 PGS004747
(creatinine_PRSmix_eur)
 PSS011488|
European Ancestry|
5,758 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Serum creatinine — — Incremental R2 (Full model versus model with only covariates): 0.046 [0.035, 0.056] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020973 PGS004748
(creatinine_PRSmix_sas)
 PSS011489|
South Asian Ancestry|
6,954 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Serum creatinine — — Incremental R2 (Full model versus model with only covariates): 0.029 [0.022, 0.037] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020974 PGS004749
(creatinine_PRSmixPlus_eur)
 PSS011488|
European Ancestry|
5,758 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Serum creatinine — — Incremental R2 (Full model versus model with only covariates): 0.053 [0.042, 0.064] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)
PPM020975 PGS004750
(creatinine_PRSmixPlus_sas)
 PSS011489|
South Asian Ancestry|
6,954 individuals
 PGP000604 |
Truong B et al. Cell Genom (2024)
 Reported Trait: Serum creatinine — — Incremental R2 (Full model versus model with only covariates): 0.035 [0.027, 0.044] age, sex, PC1, PC2, PC3, PC4, PC5, PC6, PC7, PC8, PC9, PC10 Incremental R2 (Full model versus model with only covariates)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007883 — — 2,345 individuals — African American or Afro-Caribbean Carribean UKB —
PSS010805 — — 3,939 individuals,
38.0 % Male samples
 Mean = 54.4 years
Sd = 7.5 years		 European Polish UKB —
PSS008541 — — 1,124 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009439 — — 18,993 individuals — European UK (+ Ireland) UKB —
PSS010553 — — 1,095 individuals,
60.0 % Male samples
 Mean = 51.9 years
Sd = 8.0 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS007131 — — 6,097 individuals — African unspecified — UKB —
PSS007132 — — 1,615 individuals — East Asian — UKB —
PSS007133 — — 23,762 individuals — European non-white British ancestry UKB —
PSS007134 — — 7,427 individuals — South Asian — UKB —
PSS007135 — — 64,433 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS010301 — — 2,333 individuals,
37.0 % Male samples
 Mean = 52.5 years
Sd = 8.1 years		 African American or Afro-Caribbean Caribbean UKB —
PSS011488 — — 5,758 individuals — European — AllofUs —
PSS011489 — — 6,954 individuals — South Asian — G&H —
PSS009213 — — 3,950 individuals — European Poland (NE Europe) UKB —
PSS008319 — — 6,003 individuals — South Asian India (South Asia) UKB —
PSS010721 — — 3,626 individuals,
46.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010469 — — 5,949 individuals,
54.0 % Male samples
 Mean = 53.3 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010217 — — 2,235 individuals,
45.0 % Male samples
 Mean = 58.1 years
Sd = 7.1 years		 European Ashkenazi UKB —
PSS008987 — — 3,655 individuals — African unspecified Nigeria (West Africa) UKB —
PSS011364 — — 56,192 individuals — European — UKB —
PSS008096 — — 1,716 individuals — East Asian China (East Asia) UKB —
PSS010889 — — 19,112 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010637 — — 6,170 individuals,
45.0 % Male samples
 Mean = 54.4 years
Sd = 8.4 years		 European Italian UKB —
PSS010385 — — 1,705 individuals,
33.0 % Male samples
 Mean = 52.4 years
Sd = 7.8 years		 East Asian Chinese UKB —
PSS000667 — — 6,016 individuals — African unspecified — UKB —
PSS000668 — — 1,081 individuals — East Asian — UKB —
PSS000674 — — 23,576 individuals — European Non-British White UKB —
PSS000800 — — 2,129 individuals — European Participants self-identifying as white MESA —
PSS008767 — — 6,322 individuals — European Italy (South Europe) UKB —
PSS000675 — — 7,339 individuals — South Asian — UKB —
PSS000676 — — 63,758 individuals — European
(British)		 — UKB —