Trait: serum non-albumin protein measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004568
Description The measurement of the non-albumin portion of blood protein (globulin) in serum
Trait category
Other measurement

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000691
(snpnet.Non_albumin_protein)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Non-albumin protein [g/L] serum non-albumin protein measurement 18,670
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000691/ScoringFiles/PGS000691.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001419 PGS000691
(snpnet.Non_albumin_protein)
 PSS000729|
African Ancestry|
5,573 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Non-albumin protein [g/L] — — R²: 0.07146
Spearman's ρ: 0.16		 Age, sex, PCs(1-40) —
PPM001454 PGS000691
(snpnet.Non_albumin_protein)
 PSS000730|
East Asian Ancestry|
984 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Non-albumin protein [g/L] — — R²: 0.0886
Spearman's ρ: 0.216		 Age, sex, PCs(1-40) —
PPM001489 PGS000691
(snpnet.Non_albumin_protein)
 PSS000731|
European Ancestry|
21,516 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Non-albumin protein [g/L] — — R²: 0.12839
Spearman's ρ: 0.31		 Age, sex, PCs(1-40) —
PPM001524 PGS000691
(snpnet.Non_albumin_protein)
 PSS000732|
South Asian Ancestry|
6,687 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Non-albumin protein [g/L] — — R²: 0.15158
Spearman's ρ: 0.292		 Age, sex, PCs(1-40) —
PPM001559 PGS000691
(snpnet.Non_albumin_protein)
 PSS000733|
European Ancestry|
58,196 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Non-albumin protein [g/L] — — R²: 0.12321
Spearman's ρ: 0.311		 Age, sex, PCs(1-40) —
PPM007380 PGS000691
(snpnet.Non_albumin_protein)
 PSS006916|
African Ancestry|
5,573 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Non-albumin protein — — R²: 0.02946 [0.02136, 0.03756]
Incremental R2 (full-covars): 0.02412
PGS R2 (no covariates): 0.02397 [0.01663, 0.03132]		 age, sex, UKB array type, Genotype PCs —
PPM007381 PGS000691
(snpnet.Non_albumin_protein)
 PSS006917|
East Asian Ancestry|
1,436 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Non-albumin protein — — R²: 0.09152 [0.06547, 0.11756]
Incremental R2 (full-covars): 0.05716
PGS R2 (no covariates): 0.06672 [0.04387, 0.08956]		 age, sex, UKB array type, Genotype PCs —
PPM007382 PGS000691
(snpnet.Non_albumin_protein)
 PSS006918|
European Ancestry|
21,514 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Non-albumin protein — — R²: 0.09985 [0.09278, 0.10691]
Incremental R2 (full-covars): 0.09891
PGS R2 (no covariates): 0.09939 [0.09234, 0.10644]		 age, sex, UKB array type, Genotype PCs —
PPM007383 PGS000691
(snpnet.Non_albumin_protein)
 PSS006919|
South Asian Ancestry|
6,643 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Non-albumin protein — — R²: 0.09351 [0.08124, 0.10578]
Incremental R2 (full-covars): 0.08375
PGS R2 (no covariates): 0.08889 [0.07686, 0.10091]		 age, sex, UKB array type, Genotype PCs —
PPM007384 PGS000691
(snpnet.Non_albumin_protein)
 PSS006920|
European Ancestry|
58,191 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: Non-albumin protein — — R²: 0.10006 [0.09577, 0.10436]
Incremental R2 (full-covars): 0.10006
PGS R2 (no covariates): 0.10018 [0.09588, 0.10448]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS006916 — — 5,573 individuals — African unspecified — UKB —
PSS006917 — — 1,436 individuals — East Asian — UKB —
PSS006918 — — 21,514 individuals — European non-white British ancestry UKB —
PSS006919 — — 6,643 individuals — South Asian — UKB —
PSS006920 — — 58,191 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS000729 — — 5,573 individuals — African unspecified — UKB —
PSS000730 — — 984 individuals — East Asian — UKB —
PSS000731 — — 21,516 individuals — European Non-British White UKB —
PSS000732 — — 6,687 individuals — South Asian — UKB —
PSS000733 — — 58,196 individuals — European
(British)		 — UKB —