Trait: estradiol measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0004697
Description Is a quantification of circulating estradiol a circulating steriod sex hormone.
Trait category
Other measurement
Synonyms 3 synonyms
  • estradiol levels
  • oestrogen level
  • oestrogen levels
Mapped terms 2 mapped terms
  • NCIt:C74782
  • SNOMEDCT:37538009

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001182
(GBE_BIN10030800)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Estradiol [> 212 pmol/L] estradiol measurement 351
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001182/ScoringFiles/PGS001182.txt.gz
PGS002914
(ExPRSweb_Estradiol_30800-irnt_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estradiol estradiol measurement 326,223
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002914/ScoringFiles/PGS002914.txt.gz
PGS002915
(ExPRSweb_Estradiol_30800-irnt_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estradiol estradiol measurement 4,661
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002915/ScoringFiles/PGS002915.txt.gz
PGS002916
(ExPRSweb_Estradiol_30800-irnt_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estradiol estradiol measurement 9,583
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002916/ScoringFiles/PGS002916.txt.gz
PGS002917
(ExPRSweb_Estradiol_30800-irnt_DBSLMM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estradiol estradiol measurement 10,287,664
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002917/ScoringFiles/PGS002917.txt.gz
PGS002918
(ExPRSweb_Estradiol_30800-irnt_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estradiol estradiol measurement 1,113,823
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002918/ScoringFiles/PGS002918.txt.gz
PGS002919
(ExPRSweb_Estradiol_30800-raw_LASSOSUM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estradiol estradiol measurement 324,623
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002919/ScoringFiles/PGS002919.txt.gz
PGS002920
(ExPRSweb_Estradiol_30800-raw_PT_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estradiol estradiol measurement 4
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002920/ScoringFiles/PGS002920.txt.gz
PGS002921
(ExPRSweb_Estradiol_30800-raw_PLINK_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estradiol estradiol measurement 98
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002921/ScoringFiles/PGS002921.txt.gz
PGS002922
(ExPRSweb_Estradiol_30800-raw_DBSLMM_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estradiol estradiol measurement 10,287,670
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002922/ScoringFiles/PGS002922.txt.gz
PGS002923
(ExPRSweb_Estradiol_30800-raw_PRSCS_MGI_20211120)
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Estradiol estradiol measurement 1,113,823
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002923/ScoringFiles/PGS002923.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008599 PGS001182
(GBE_BIN10030800)
 PSS003617|
African Ancestry|
5,634 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Oestradiol > 212 pmol/L — AUROC: 0.84561 [0.83153, 0.85969] R²: 0.36666
Incremental AUROC (full-covars): 0.0004
PGS R2 (no covariates): 0.00269
PGS AUROC (no covariates): 0.52894 [0.51075, 0.54713]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008600 PGS001182
(GBE_BIN10030800)
 PSS003618|
East Asian Ancestry|
1,519 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Oestradiol > 212 pmol/L — AUROC: 0.87744 [0.85387, 0.90101] R²: 0.4381
Incremental AUROC (full-covars): 0.00067
PGS R2 (no covariates): 0.00244
PGS AUROC (no covariates): 0.52764 [0.49274, 0.56254]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008601 PGS001182
(GBE_BIN10030800)
 PSS003619|
European Ancestry|
22,152 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Oestradiol > 212 pmol/L — AUROC: 0.86243 [0.85486, 0.87001] R²: 0.40572
Incremental AUROC (full-covars): 0.00045
PGS R2 (no covariates): 0.00134
PGS AUROC (no covariates): 0.52174 [0.51159, 0.5319]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008602 PGS001182
(GBE_BIN10030800)
 PSS003620|
South Asian Ancestry|
6,943 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Oestradiol > 212 pmol/L — AUROC: 0.84655 [0.8301, 0.86301] R²: 0.36479
Incremental AUROC (full-covars): -0.00035
PGS R2 (no covariates): 1e-05
PGS AUROC (no covariates): 0.50081 [0.48154, 0.52008]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008603 PGS001182
(GBE_BIN10030800)
 PSS003621|
European Ancestry|
59,957 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Oestradiol > 212 pmol/L — AUROC: 0.85144 [0.84586, 0.85701] R²: 0.36546
Incremental AUROC (full-covars): 0.00059
PGS R2 (no covariates): 0.00121
PGS AUROC (no covariates): 0.52103 [0.51414, 0.52793]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM015793 PGS002914
(ExPRSweb_Estradiol_30800-irnt_LASSOSUM_MGI_20211120)
 PSS010003|
European Ancestry|
937 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Estradiol β: 2.0 (1.72) — R²: 0.00135 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015796 PGS002915
(ExPRSweb_Estradiol_30800-irnt_PT_MGI_20211120)
 PSS010003|
European Ancestry|
937 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Estradiol β: -2.37 (1.7) — R²: 0.00113 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015794 PGS002916
(ExPRSweb_Estradiol_30800-irnt_PLINK_MGI_20211120)
 PSS010003|
European Ancestry|
937 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Estradiol β: 2.02 (1.7) — R²: 0.00141 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015792 PGS002917
(ExPRSweb_Estradiol_30800-irnt_DBSLMM_MGI_20211120)
 PSS010003|
European Ancestry|
937 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Estradiol β: 2.1 (1.62) — R²: 0.00272 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015795 PGS002918
(ExPRSweb_Estradiol_30800-irnt_PRSCS_MGI_20211120)
 PSS010003|
European Ancestry|
937 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Estradiol β: 1.86 (1.69) — R²: 0.00158 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015798 PGS002919
(ExPRSweb_Estradiol_30800-raw_LASSOSUM_MGI_20211120)
 PSS010003|
European Ancestry|
937 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Estradiol β: 1.83 (1.68) — R²: 0.00151 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015801 PGS002920
(ExPRSweb_Estradiol_30800-raw_PT_MGI_20211120)
 PSS010003|
European Ancestry|
937 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Estradiol β: 0.534 (1.69) — R²: 0.00032 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015799 PGS002921
(ExPRSweb_Estradiol_30800-raw_PLINK_MGI_20211120)
 PSS010003|
European Ancestry|
937 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Estradiol β: 0.417 (1.62) — R²: 0.00012 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015797 PGS002922
(ExPRSweb_Estradiol_30800-raw_DBSLMM_MGI_20211120)
 PSS010003|
European Ancestry|
937 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Estradiol β: 1.24 (1.63) — R²: 0.00106 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —
PPM015800 PGS002923
(ExPRSweb_Estradiol_30800-raw_PRSCS_MGI_20211120)
 PSS010003|
European Ancestry|
937 individuals
 PGP000393 |
Ma Y et al. Am J Hum Genet (2022)
 Reported Trait: Estradiol β: 3.31 (1.66) — R²: 0.00441 SEX,AGE,Batch,PC1,PC2,PC3,PC4 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003617 — —
[
  • 1,208 cases
  • , 4,426 controls
]
 — African unspecified — UKB —
PSS003618 — —
[
  • 309 cases
  • , 1,210 controls
]
 — East Asian — UKB —
PSS003619 — —
[
  • 3,703 cases
  • , 18,449 controls
]
 — European non-white British ancestry UKB —
PSS003620 — —
[
  • 1,023 cases
  • , 5,920 controls
]
 — South Asian — UKB —
PSS003621 — —
[
  • 7,653 cases
  • , 52,304 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS010003 ESTRADIOL LEVEL (LOINC: 2243-4); Quantitative — 937 individuals — European — MGI —